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'''Frederick Kaplan''' is an American [[orthopedic surgeon]] and [[molecular geneticist]] renowned for his work on [[fibrodysplasia ossificans progressiva]] (FOP), a rare and disabling genetic condition. Kaplan is the Isaac & Rose Nassau Professor of Orthopaedic Molecular Medicine at the [[University of Pennsylvania]]'s Perelman School of Medicine.
{{DISPLAYTITLE:Frederick Kaplan}}
 
== Frederick Kaplan ==
[[File:Dr_Frederick_S_Kaplan.JPG|thumb|right|Dr. Frederick S. Kaplan]]
 
'''Frederick S. Kaplan''' is a renowned American physician and researcher, best known for his groundbreaking work in the field of [[genetic disorders]], particularly [[fibrodysplasia ossificans progressiva]] (FOP). He holds the position of the Isaac & Rose Nassau Professor of Orthopaedic Molecular Medicine at the [[Perelman School of Medicine]] at the [[University of Pennsylvania]].


== Early Life and Education ==
== Early Life and Education ==
Frederick Kaplan was born in [[Brooklyn]], New York. He completed his undergraduate studies at the [[University of Wisconsin–Madison]], where he majored in [[biochemistry]]. He then attended the [[University of Pennsylvania]] for his medical degree.
Frederick Kaplan was born in the United States and developed an early interest in medicine and science. He pursued his undergraduate studies at [[Johns Hopkins University]], where he graduated with a degree in biology. He then attended the [[Johns Hopkins School of Medicine]], earning his [[Doctor of Medicine|MD]] degree.


== Career ==
== Career ==
Kaplan has dedicated his career to studying and treating FOP, a condition that causes soft tissues to progressively turn into bone. He is the co-founder of the [[International Fibrodysplasia Ossificans Progressiva Association]] (IFOPA), a non-profit organization that supports research, education, and communication for FOP families.
After completing his medical degree, Kaplan undertook residency training in [[orthopaedic surgery]] at the [[Hospital of the University of Pennsylvania]]. He further specialized in [[molecular genetics]] and [[orthopaedic research]], which laid the foundation for his future work in rare genetic diseases.
 
=== Research on Fibrodysplasia Ossificans Progressiva ===
Kaplan's most notable contribution to medical science is his research on fibrodysplasia ossificans progressiva (FOP), a rare and debilitating genetic disorder characterized by the abnormal development of bone in muscles, tendons, and other connective tissues. His work led to the identification of the [[ACVR1]] gene mutation responsible for FOP, a discovery that has opened new avenues for understanding and potentially treating this condition.


In 2006, Kaplan and his team identified the gene mutation responsible for FOP, a breakthrough that has paved the way for potential treatments. His research has been recognized with numerous awards, including the [[National Organization for Rare Disorders]] (NORD) Lifetime Achievement Award.
=== Academic Contributions ===
In addition to his research, Kaplan has been a dedicated educator, mentoring numerous students and fellows in the field of orthopaedic molecular medicine. He has published extensively in scientific journals and has been a keynote speaker at various international conferences on genetic disorders and orthopaedic research.


== Research ==
== Awards and Honors ==
Kaplan's research focuses on the molecular mechanisms of FOP. His team discovered that a mutation in the [[ACVR1]] gene causes the condition. This gene normally produces a protein that controls bone and muscle growth, but the mutation causes it to function abnormally, leading to the formation of extra-skeletal bone.
Kaplan's contributions to medicine and science have been recognized with numerous awards and honors. He has received accolades from prestigious organizations such as the [[American Academy of Orthopaedic Surgeons]] and the [[National Institutes of Health]].


== Awards and Recognition ==
== Personal Life ==
Kaplan has received numerous awards for his work, including the [[American Academy of Orthopaedic Surgeons]]' Kappa Delta Award and the [[National Institutes of Health]]'s Pioneer Award. He was also named a "Hero of Medicine" by [[TIME magazine]] in 2001.
Frederick Kaplan is married and has children. He is known for his passion for teaching and his commitment to advancing medical research. Outside of his professional life, he enjoys reading and spending time with his family.


== References ==
== Related Pages ==
<references />
* [[Fibrodysplasia ossificans progressiva]]
* [[Genetic disorders]]
* [[Orthopaedic surgery]]
* [[Perelman School of Medicine]]


[[Category:American orthopedic surgeons]]
[[Category:American physicians]]
[[Category:American geneticists]]
[[Category:Orthopaedic surgeons]]
[[Category:Medical researchers]]
[[Category:Johns Hopkins University alumni]]
[[Category:University of Pennsylvania faculty]]
[[Category:University of Pennsylvania faculty]]
[[Category:People from Brooklyn]]
[[Category:University of Wisconsin–Madison alumni]]
[[Category:Perelman School of Medicine at the University of Pennsylvania alumni]]
{{medicine-stub}}

Latest revision as of 05:54, 16 February 2025


Frederick Kaplan[edit]

Dr. Frederick S. Kaplan

Frederick S. Kaplan is a renowned American physician and researcher, best known for his groundbreaking work in the field of genetic disorders, particularly fibrodysplasia ossificans progressiva (FOP). He holds the position of the Isaac & Rose Nassau Professor of Orthopaedic Molecular Medicine at the Perelman School of Medicine at the University of Pennsylvania.

Early Life and Education[edit]

Frederick Kaplan was born in the United States and developed an early interest in medicine and science. He pursued his undergraduate studies at Johns Hopkins University, where he graduated with a degree in biology. He then attended the Johns Hopkins School of Medicine, earning his MD degree.

Career[edit]

After completing his medical degree, Kaplan undertook residency training in orthopaedic surgery at the Hospital of the University of Pennsylvania. He further specialized in molecular genetics and orthopaedic research, which laid the foundation for his future work in rare genetic diseases.

Research on Fibrodysplasia Ossificans Progressiva[edit]

Kaplan's most notable contribution to medical science is his research on fibrodysplasia ossificans progressiva (FOP), a rare and debilitating genetic disorder characterized by the abnormal development of bone in muscles, tendons, and other connective tissues. His work led to the identification of the ACVR1 gene mutation responsible for FOP, a discovery that has opened new avenues for understanding and potentially treating this condition.

Academic Contributions[edit]

In addition to his research, Kaplan has been a dedicated educator, mentoring numerous students and fellows in the field of orthopaedic molecular medicine. He has published extensively in scientific journals and has been a keynote speaker at various international conferences on genetic disorders and orthopaedic research.

Awards and Honors[edit]

Kaplan's contributions to medicine and science have been recognized with numerous awards and honors. He has received accolades from prestigious organizations such as the American Academy of Orthopaedic Surgeons and the National Institutes of Health.

Personal Life[edit]

Frederick Kaplan is married and has children. He is known for his passion for teaching and his commitment to advancing medical research. Outside of his professional life, he enjoys reading and spending time with his family.

Related Pages[edit]