Sodium salicylate: Difference between revisions

Latest revision as of 05:24, 16 February 2025

Sodium Salicylate[edit]

Sodium salicylate is a sodium salt of salicylic acid, a non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. It is commonly used in the treatment of pain, fever, and inflammation.

Chemical Properties[edit]

Sodium salicylate is a white, crystalline powder that is soluble in water. It has the chemical formula C₇H₅NaO₃ and a molecular weight of 160.11 g/mol. The compound is known for its ability to inhibit the enzyme cyclooxygenase, which is involved in the synthesis of prostaglandins, thereby reducing inflammation and pain.

Pharmacology[edit]

Sodium salicylate works by inhibiting the production of prostaglandins, which are chemicals in the body that promote inflammation, pain, and fever. By blocking the enzyme cyclooxygenase, sodium salicylate reduces the levels of prostaglandins, leading to decreased inflammation and pain relief.

Medical Uses[edit]

Sodium salicylate is used to treat a variety of conditions, including:

Rheumatoid arthritis
Osteoarthritis
Gout
Fever
Mild to moderate pain

Side Effects[edit]

Common side effects of sodium salicylate include gastrointestinal irritation, nausea, and dizziness. In some cases, it may cause more serious side effects such as gastrointestinal bleeding or allergic reactions.

History[edit]

Sodium salicylate was one of the first synthetic drugs used to treat pain and inflammation. It was developed in the late 19th century and was widely used before the advent of more modern NSAIDs like aspirin.

Synthesis[edit]

Sodium salicylate can be synthesized by neutralizing salicylic acid with sodium hydroxide. The reaction produces sodium salicylate and water as byproducts.

Related Compounds[edit]

Aspirin (acetylsalicylic acid)
Salicylic acid
Methyl salicylate

Related pages[edit]

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-'''Sodium Salicylate''' is a [[sodium]] salt of [[salicylic acid]]. It can be used in medicine as an [[analgesic]] and [[anti-inflammatory]] drug. Sodium salicylate also has [[antipyretic]] properties, making it useful for reducing fever.
+{{DISPLAYTITLE:Sodium salicylate}}
-==Chemistry==
+==Sodium Salicylate==
-Sodium salicylate is a white crystalline powder with the chemical formula C7H5NaO3. It is soluble in water and alcohol. The compound is produced by reacting [[sodium hydroxide]] with salicylic acid.
+[[File:Sodium_salicylate2DCSD.svg|thumb|right|Chemical structure of sodium salicylate]]
+'''Sodium salicylate''' is a sodium salt of [[salicylic acid]], a non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. It is commonly used in the treatment of pain, fever, and inflammation.
+==Chemical Properties==
+Sodium salicylate is a white, crystalline powder that is soluble in water. It has the chemical formula C<sub>7</sub>H<sub>5</sub>NaO<sub>3</sub> and a molecular weight of 160.11 g/mol. The compound is known for its ability to inhibit the enzyme [[cyclooxygenase]], which is involved in the synthesis of [[prostaglandins]], thereby reducing inflammation and pain.
+==Pharmacology==
+Sodium salicylate works by inhibiting the production of prostaglandins, which are chemicals in the body that promote inflammation, pain, and fever. By blocking the enzyme cyclooxygenase, sodium salicylate reduces the levels of prostaglandins, leading to decreased inflammation and pain relief.
 ==Medical Uses==
-Sodium salicylate is used as a non-steroidal anti-inflammatory drug (NSAID). It works by inhibiting the production of [[prostaglandins]], chemicals in the body that cause inflammation and pain. Sodium salicylate is used to relieve pain from various conditions such as [[headache]], [[muscle aches]], [[arthritis]], and [[menstrual cramps]]. It is also used to reduce fever and to relieve the symptoms of [[cold]] and [[flu]].
+Sodium salicylate is used to treat a variety of conditions, including:
+* [[Rheumatoid arthritis]]
+* [[Osteoarthritis]]
+* [[Gout]]
+* [[Fever]]
+* Mild to moderate pain
 ==Side Effects==
-Like other NSAIDs, sodium salicylate can cause side effects. These may include [[nausea]], [[vomiting]], [[diarrhea]], and [[stomach upset]]. In rare cases, it can cause serious side effects such as [[bleeding]], [[ulceration]], and perforation of the stomach or intestines.
+Common side effects of sodium salicylate include gastrointestinal irritation, nausea, and dizziness. In some cases, it may cause more serious side effects such as [[gastrointestinal bleeding]] or [[allergic reactions]].
-==Precautions==
+==History==
-Before using sodium salicylate, individuals should inform their healthcare provider if they have any allergies, especially to aspirin or other NSAIDs. It should be used with caution in patients with a history of [[stomach ulcers]] or [[bleeding disorders]]. Sodium salicylate should not be used during the last trimester of pregnancy due to the potential for fetal harm.
+Sodium salicylate was one of the first synthetic drugs used to treat pain and inflammation. It was developed in the late 19th century and was widely used before the advent of more modern NSAIDs like [[aspirin]].
-==Interactions==
+==Synthesis==
-Sodium salicylate may interact with other medications, including [[blood thinners]], [[corticosteroids]], and certain [[antidepressants]]. It can also interact with alcohol, increasing the risk of stomach bleeding.
+Sodium salicylate can be synthesized by neutralizing salicylic acid with sodium hydroxide. The reaction produces sodium salicylate and water as byproducts.
-==See Also==
+==Related Compounds==
+* [[Aspirin]] (acetylsalicylic acid)
 * [[Salicylic acid]]
-* [[Nonsteroidal anti-inflammatory drug]]
+* [[Methyl salicylate]]
-* [[Analgesic]]
-* [[Antipyretic]]
+==Related pages==
+* [[Non-steroidal anti-inflammatory drug]]
+* [[Pain management]]
+* [[Inflammation]]
-[[Category:Drugs]]
+[[Category:Non-steroidal anti-inflammatory drugs]]
-[[Category:Nonsteroidal anti-inflammatory drugs]]
 [[Category:Analgesics]]
-[[Category:Antipyretics]]
+[[Category:Salicylates]]
-{{Medicine-stub}}
-{{Pharma-stub}}