Ethylestrenol: Difference between revisions

Latest revision as of 05:19, 16 February 2025

Anabolic steroid

Overview[edit]

Ethylestrenol is an anabolic steroid that is derived from nandrolone. It is known for its ability to promote muscle growth and increase strength. Ethylestrenol is a synthetic derivative of the naturally occurring hormone testosterone.

Chemical Structure[edit]

Ethylestrenol is chemically related to norethandrolone, as shown in the image to the right. It is a 19-nortestosterone derivative, which means it lacks a carbon atom at the 19th position compared to testosterone. This modification is responsible for its anabolic properties.

Pharmacology[edit]

Ethylestrenol exhibits strong anabolic effects with relatively low androgenic effects. This makes it a popular choice for athletes and bodybuilders looking to enhance performance without the pronounced side effects associated with more androgenic steroids. It is metabolized in the liver and excreted primarily through the kidneys.

Medical Uses[edit]

Ethylestrenol has been used in the treatment of conditions such as muscle wasting and osteoporosis. It helps in promoting weight gain and increasing muscle mass in patients who have experienced severe weight loss due to chronic illness or surgery.

Side Effects[edit]

Like other anabolic steroids, ethylestrenol can cause a range of side effects. These may include liver damage, cardiovascular issues, and hormonal imbalances. Long-term use can lead to testicular atrophy and infertility in men, as well as virilization in women.

Legal Status[edit]

The use of ethylestrenol is regulated in many countries due to its potential for abuse in sports. It is classified as a controlled substance in the United States and many other countries, meaning it is illegal to use without a prescription.

Related Compounds[edit]

Ethylestrenol is closely related to other anabolic steroids such as nandrolone and norethandrolone. These compounds share similar anabolic properties but differ in their specific chemical structures and side effect profiles.

Related pages[edit]

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-'''Ethylestrenol''', also known by its developmental code name '''Orgasteron''' and sold under the brand name '''Maxibolin''' among others, is an [[anabolic steroid]] that was first described in 1960 and introduced for medical use in 1964. It is an orally active [[17α-alkylated]] derivative of [[nandrolone]] (19-nortestosterone). Ethylestrenol is used in the treatment of conditions associated with [[catabolism]] and tissue wasting, such as chronic debilitating diseases, recovery from major surgery, and osteoporosis. Despite its medical applications, its use has been limited due to its weak anabolic effects and it has been largely replaced by more potent anabolic steroids.
+{{short description|Anabolic steroid}}
+{{DISPLAYTITLE:Ethylestrenol}}
-==Medical Uses==
+==Overview==
-Ethylestrenol is indicated for the treatment of conditions that require a mild anabolic agent, such as [[chronic obstructive pulmonary disease]] (COPD), [[osteoporosis]], and certain cases of [[anemia]]. It has also been used to promote weight gain after surgery, chronic infections, or severe trauma.
+[[File:Norethandrolone_structure.png|thumb|right|Chemical structure of Norethandrolone, a related compound]]
+'''Ethylestrenol''' is an [[anabolic steroid]] that is derived from [[nandrolone]]. It is known for its ability to promote muscle growth and increase strength. Ethylestrenol is a synthetic derivative of the naturally occurring hormone [[testosterone]].
+==Chemical Structure==
+Ethylestrenol is chemically related to [[norethandrolone]], as shown in the image to the right. It is a 19-nortestosterone derivative, which means it lacks a carbon atom at the 19th position compared to testosterone. This modification is responsible for its anabolic properties.
 ==Pharmacology==
-===Mechanism of Action===
+Ethylestrenol exhibits strong anabolic effects with relatively low androgenic effects. This makes it a popular choice for athletes and bodybuilders looking to enhance performance without the pronounced side effects associated with more androgenic steroids. It is metabolized in the liver and excreted primarily through the kidneys.
-As an anabolic steroid, ethylestrenol exerts its effects by binding to and activating the [[androgen receptor]] (AR). This leads to an increase in protein synthesis and an overall anabolic effect in muscle and bone tissue. However, its affinity for the AR is significantly lower than that of testosterone and other more potent anabolic steroids, which accounts for its relatively weak anabolic effects.
-===Pharmacokinetics===
+==Medical Uses==
-Ethylestrenol is well absorbed from the gastrointestinal tract, but it undergoes significant [[first-pass metabolism]] in the liver, which reduces its bioavailability. Its 17α-alkylated structure, however, helps it resist complete breakdown by the liver, allowing a portion of the drug to enter circulation and exert its effects.
+Ethylestrenol has been used in the treatment of conditions such as [[muscle wasting]] and [[osteoporosis]]. It helps in promoting weight gain and increasing muscle mass in patients who have experienced severe weight loss due to chronic illness or surgery.
-==Adverse Effects==
+==Side Effects==
-The adverse effects of ethylestrenol are similar to those of other anabolic steroids and can include [[liver toxicity]], changes in [[lipid profiles]], and potential effects on [[cardiovascular health]]. Due to its relatively weak anabolic activity, the risk of severe side effects is lower compared to more potent anabolic steroids. However, long-term use or high doses can still lead to significant health risks.
+Like other anabolic steroids, ethylestrenol can cause a range of side effects. These may include [[liver damage]], [[cardiovascular issues]], and [[hormonal imbalances]]. Long-term use can lead to [[testicular atrophy]] and [[infertility]] in men, as well as [[virilization]] in women.
 ==Legal Status==
-The legal status of ethylestrenol varies by country. In some jurisdictions, it is classified as a controlled substance, which restricts its use and distribution. Its non-medical use, such as for bodybuilding or performance enhancement, is generally prohibited.
+The use of ethylestrenol is regulated in many countries due to its potential for abuse in sports. It is classified as a controlled substance in the United States and many other countries, meaning it is illegal to use without a prescription.
+==Related Compounds==
+Ethylestrenol is closely related to other anabolic steroids such as [[nandrolone]] and [[norethandrolone]]. These compounds share similar anabolic properties but differ in their specific chemical structures and side effect profiles.
-==See Also==
+==Related pages==
 * [[Anabolic steroid]]
 * [[Nandrolone]]
-* [[Androgen receptor]]
+* [[Testosterone]]
-* [[Liver toxicity]]
+* [[Muscle wasting]]
-* [[Lipid profile]]
+* [[Osteoporosis]]
 [[Category:Anabolic steroids]]
-[[Category:C17α-alkylated steroids]]
-{{medicine-stub}}