Phenylbiguanide: Difference between revisions

Latest revision as of 11:48, 15 February 2025

Phenylbiguanide[edit]

Phenylbiguanide is a chemical compound that belongs to the class of biguanides. It is characterized by the presence of a phenyl group attached to a biguanide moiety. Phenylbiguanide is primarily used in scientific research, particularly in the study of serotonin receptors and cardiovascular reflexes.

Chemical Structure[edit]

Phenylbiguanide has the chemical formula C₈H₁₁N₅. The structure consists of a phenyl group (C₆H₅) attached to a biguanide group (C₂H₆N₅). The presence of the phenyl group influences the compound's lipophilicity and its ability to interact with biological membranes.

Mechanism of Action[edit]

Phenylbiguanide is known to act as an agonist at certain subtypes of serotonin receptors, particularly the 5-HT₃ receptor. Activation of these receptors can lead to various physiological responses, including modulation of neurotransmitter release and influence on gastrointestinal motility.

Applications in Research[edit]

Phenylbiguanide is used in experimental settings to study the role of serotonin receptors in the central nervous system and peripheral tissues. It is also employed in research on the cardiovascular system, where it is used to investigate reflexes such as the Bezold-Jarisch reflex, which involves a decrease in heart rate and blood pressure in response to certain stimuli.

Safety and Handling[edit]

As with many chemical compounds used in research, phenylbiguanide should be handled with care. Appropriate laboratory safety protocols should be followed to prevent exposure and ensure safe handling.

Related Pages[edit]

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-'''Phenylbiguanide''' is a compound that is often used in scientific research, particularly in studies related to the [[cardiovascular system]] and [[serotonin]] receptors. It is known to stimulate [[5-HT3 receptors]], which are a type of serotonin receptor found primarily in the brain and in the gastrointestinal tract.
+{{DISPLAYTITLE:Phenylbiguanide}}
-==Chemical Structure==
+== Phenylbiguanide ==
-Phenylbiguanide has a chemical structure that includes a phenyl ring and a biguanide group. The phenyl ring is a functional group of the form -C6H5, which consists of a benzene ring minus one hydrogen atom. The biguanide group is a functional group consisting of two [[guanidine]] groups, with the formula -NHC(=NH)NHC(NH2)2.
-==Uses in Research==
+[[File:1-Phenylbiguanide.svg|thumb|right|Structural formula of phenylbiguanide]]
-Phenylbiguanide is often used in research due to its ability to stimulate 5-HT3 receptors. This makes it useful in studies investigating the role of these receptors in various physiological processes. For example, it has been used in studies looking at the role of 5-HT3 receptors in the regulation of the cardiovascular system, as well as in studies investigating the role of these receptors in the gastrointestinal tract.
-==Pharmacological Effects==
+'''Phenylbiguanide''' is a chemical compound that belongs to the class of [[biguanides]]. It is characterized by the presence of a phenyl group attached to a biguanide moiety. Phenylbiguanide is primarily used in scientific research, particularly in the study of [[serotonin]] receptors and [[cardiovascular system|cardiovascular]] reflexes.
-When phenylbiguanide is administered, it can have a number of pharmacological effects. These are primarily due to its stimulation of 5-HT3 receptors. For example, it can cause a decrease in heart rate and blood pressure, as well as an increase in gastric motility. These effects can be useful in the study of various diseases and conditions, such as [[hypertension]] and [[gastrointestinal disorders]].
-==Safety and Toxicity==
+== Chemical Structure ==
-Like all compounds, phenylbiguanide has the potential to be toxic if not handled correctly. It is important that it is used in a controlled environment, and that appropriate safety measures are taken. This includes the use of personal protective equipment, and the proper disposal of any waste materials.
+Phenylbiguanide has the chemical formula C<sub>8</sub>H<sub>11</sub>N<sub>5</sub>. The structure consists of a phenyl group (C<sub>6</sub>H<sub>5</sub>) attached to a biguanide group (C<sub>2</sub>H<sub>6</sub>N<sub>5</sub>). The presence of the phenyl group influences the compound's [[lipophilicity]] and its ability to interact with biological membranes.
+== Mechanism of Action ==
+Phenylbiguanide is known to act as an agonist at certain subtypes of [[serotonin receptor|serotonin receptors]], particularly the 5-HT<sub>3</sub> receptor. Activation of these receptors can lead to various physiological responses, including modulation of [[neurotransmitter]] release and influence on [[gastrointestinal tract|gastrointestinal]] motility.
+== Applications in Research ==
+Phenylbiguanide is used in experimental settings to study the role of serotonin receptors in the [[central nervous system]] and peripheral tissues. It is also employed in research on the [[cardiovascular system]], where it is used to investigate reflexes such as the [[Bezold-Jarisch reflex]], which involves a decrease in heart rate and blood pressure in response to certain stimuli.
+== Safety and Handling ==
+As with many chemical compounds used in research, phenylbiguanide should be handled with care. Appropriate [[laboratory safety]] protocols should be followed to prevent exposure and ensure safe handling.
+== Related Pages ==
+* [[Biguanide]]
+* [[Serotonin receptor]]
+* [[Cardiovascular system]]
+* [[Neurotransmitter]]
 [[Category:Chemical compounds]]
 [[Category:Pharmacology]]
-[[Category:Research]]
-{{stub}}