Iofetamine (123I): Difference between revisions

Latest revision as of 11:35, 15 February 2025

A radiopharmaceutical used in brain imaging

Iofetamine (123I)[edit]

Iofetamine (123I), also known as N-isopropyl-p-iodoamphetamine (IMP), is a radiopharmaceutical agent used primarily in nuclear medicine for brain imaging. It is a derivative of amphetamine and is labeled with the radioactive isotope iodine-123.

Chemical properties[edit]

Iofetamine is a lipophilic compound, which allows it to cross the blood-brain barrier efficiently. The presence of the iodine-123 isotope enables it to be detected using single-photon emission computed tomography (SPECT), a type of nuclear imaging technique.

Mechanism of action[edit]

Once administered, iofetamine (123I) is taken up by the brain tissue, where it is distributed in proportion to the regional cerebral blood flow. This property makes it useful for assessing cerebral perfusion and identifying areas of altered blood flow, which can be indicative of various neurological disorders.

Clinical applications[edit]

Iofetamine (123I) is used in the evaluation of several neurological conditions, including:

Stroke: To assess the extent of brain tissue affected by ischemia.
Epilepsy: To localize epileptogenic foci by identifying regions of altered perfusion.
Dementia: To evaluate patterns of cerebral blood flow that may be characteristic of different types of dementia.

Administration and imaging[edit]

The compound is typically administered intravenously. After administration, imaging is performed using a SPECT camera, which detects the gamma rays emitted by the decay of iodine-123. The resulting images provide information about the distribution of blood flow in the brain.

Safety and side effects[edit]

Iofetamine (123I) is generally well-tolerated. However, as with any radiopharmaceutical, there is a small risk of radiation exposure. The use of iodine-123, which has a relatively short half-life, helps to minimize this risk. Common side effects are rare but may include mild allergic reactions.

Related pages[edit]

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-'''Iofetamine (123I)''' is a [[radioactive isotope]] used in [[nuclear medicine]] for the purpose of [[brain imaging]]. It is also known by its brand name, '''Neurolite'''. This [[radiopharmaceutical]] is used primarily in the detection and diagnosis of certain brain disorders, such as [[stroke]] and [[dementia]].
+{{Short description|A radiopharmaceutical used in brain imaging}}
+{{Use dmy dates|date=October 2023}}
-==Chemistry==
+==Iofetamine (123I)==
-Iofetamine (123I) is a lipophilic amine that is labeled with [[iodine-123]], a radioactive isotope of iodine. The iodine-123 isotope decays by electron capture to an excited state of [[tellurium-123]]. The excited state of tellurium-123 then emits gamma rays, which are detected by a [[gamma camera]] to create an image of the brain.
+[[File:Iofetamine.svg|thumb|right|Chemical structure of Iofetamine (123I)]]
+'''Iofetamine (123I)''', also known as '''N-isopropyl-p-iodoamphetamine''' (IMP), is a radiopharmaceutical agent used primarily in [[nuclear medicine]] for [[brain imaging]]. It is a derivative of [[amphetamine]] and is labeled with the radioactive isotope [[iodine-123]].
-==Medical Use==
+==Chemical properties==
-In medical practice, Iofetamine (123I) is used as a [[radiotracer]] in [[single-photon emission computed tomography]] (SPECT) scans of the brain. The compound is injected into the patient's bloodstream, where it crosses the [[blood-brain barrier]] and distributes in the brain according to regional blood flow. The gamma rays emitted by the decaying iodine-123 are then detected by a gamma camera, which generates a three-dimensional image of the brain's blood flow.
+Iofetamine is a lipophilic compound, which allows it to cross the [[blood-brain barrier]] efficiently. The presence of the iodine-123 isotope enables it to be detected using [[single-photon emission computed tomography]] (SPECT), a type of [[nuclear imaging]] technique.
-This imaging technique is particularly useful in the diagnosis of conditions that affect the brain's blood flow, such as stroke and dementia. It can also be used to detect brain tumors and to evaluate the effects of treatments on brain function.
+==Mechanism of action==
+Once administered, iofetamine (123I) is taken up by the brain tissue, where it is distributed in proportion to the regional [[cerebral blood flow]]. This property makes it useful for assessing [[cerebral perfusion]] and identifying areas of altered blood flow, which can be indicative of various [[neurological disorders]].
-==Safety==
+==Clinical applications==
-As with all radiopharmaceuticals, there are risks associated with the use of Iofetamine (123I). These include the potential for allergic reactions and the risks associated with exposure to radiation. However, the benefits of accurate diagnosis and treatment generally outweigh these risks.
+Iofetamine (123I) is used in the evaluation of several neurological conditions, including:
+* [[Stroke]]: To assess the extent of brain tissue affected by ischemia.
+* [[Epilepsy]]: To localize epileptogenic foci by identifying regions of altered perfusion.
+* [[Dementia]]: To evaluate patterns of cerebral blood flow that may be characteristic of different types of dementia.
-==See Also==
+==Administration and imaging==
-* [[Iodine-123]]
+The compound is typically administered intravenously. After administration, imaging is performed using a SPECT camera, which detects the gamma rays emitted by the decay of iodine-123. The resulting images provide information about the distribution of blood flow in the brain.
-* [[Radiopharmaceutical]]
+==Safety and side effects==
+Iofetamine (123I) is generally well-tolerated. However, as with any radiopharmaceutical, there is a small risk of radiation exposure. The use of iodine-123, which has a relatively short half-life, helps to minimize this risk. Common side effects are rare but may include mild allergic reactions.
+==Related pages==
+* [[Radiopharmaceuticals]]
 * [[Single-photon emission computed tomography]]
-* [[Stroke]]
+* [[Cerebral blood flow]]
-* [[Dementia]]
+* [[Nuclear medicine]]
-==References==
-<references />
 [[Category:Radiopharmaceuticals]]
 [[Category:Nuclear medicine]]
-[[Category:Medical imaging]]
+[[Category:Brain imaging]]
-[[Category:Brain]]
-{{medicine-stub}}