C57BL/6: Difference between revisions

Latest revision as of 10:58, 15 February 2025

C57BL/6 Mouse[edit]

The C57BL/6 mouse, also known as Black 6, is one of the most commonly used inbred strains of laboratory mouses. It is widely used in biomedical research due to its well-documented genome and its susceptibility to a variety of diseases, making it an ideal model for studying human diseases.

Characteristics[edit]

C57BL/6 mice are known for their distinctive black coat color. They are often used in genetic research because they have a well-characterized genetic background. This strain is particularly useful in studies involving immunology, oncology, and neuroscience.

Behavior[edit]

C57BL/6 mice are generally more aggressive than other strains, which can be a consideration in behavioral studies. They are also known for their high levels of locomotor activity and exploratory behavior.

Health and Disease[edit]

This strain is prone to developing obesity, diabetes, and atherosclerosis, making it a valuable model for studying these conditions. C57BL/6 mice are also used in cancer research due to their susceptibility to tumor formation.

Use in Research[edit]

C57BL/6 mice are extensively used in transgenic and knockout mouse studies. Their genetic uniformity allows for consistent results across experiments, which is crucial for reproducibility in scientific research.

Genetic Engineering[edit]

The C57BL/6 strain is often used as the background strain for creating genetically modified organisms. This is because their genome has been fully sequenced, and they are amenable to gene editing techniques such as CRISPR-Cas9.

Immunological Studies[edit]

Due to their well-characterized immune system, C57BL/6 mice are frequently used in immunology research. They are particularly useful in studies involving autoimmune diseases and vaccine development.

Related Pages[edit]

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-'''C57BL/6''' is a widely used inbred strain of [[laboratory mouse]] in the field of biomedical research. It is the most common and one of the oldest strains of laboratory mice, with its origins tracing back to a breeding program initiated in the 1920s by C.C. Little. The "C57BL" stands for "C57 Black," referring to the mouse's black coat color, and the "6" denotes a specific substrain. This strain is particularly noted for its robust health, longevity, and use in a variety of research contexts, making it a standard model organism in the study of genetics, physiology, aging, and the effects of drugs.
+== C57BL/6 Mouse ==
-==Characteristics==
+[[File:Black_6_mouse_eating.jpg|thumb|right|A C57BL/6 mouse eating]]
-C57BL/6 mice are characterized by their black fur, resistance to many diseases that commonly affect other strains, and a tendency towards obesity when fed a high-fat diet. They are also known for their high alcohol preference and consumption, making them a popular choice for studies on addiction and substance abuse. Additionally, these mice exhibit aggressive behavior, especially among males, which can be a consideration in their housing and handling in laboratory settings.
-==Genetic Makeup==
+The '''C57BL/6 mouse''', also known as '''Black 6''', is one of the most commonly used [[inbred strain]]s of [[laboratory mouse]]s. It is widely used in [[biomedical research]] due to its well-documented [[genome]] and its susceptibility to a variety of diseases, making it an ideal model for studying [[human disease]]s.
-The genetic makeup of C57BL/6 mice has been extensively studied, making them a prime candidate for genetic manipulation experiments, including transgenic and knockout studies. The availability of a complete genome sequence for C57BL/6 mice enhances their utility in research, allowing for precise genetic modifications and the study of gene function and expression.
-==Use in Research==
+== Characteristics ==
-C57BL/6 mice are used in a wide array of research areas including but not limited to immunology, oncology, neurology, and developmental biology. Their widespread use is partly due to the extensive knowledge of their genetics, physiology, and behavior, which provides a solid baseline for comparative studies. They are particularly valuable in the creation of genetically modified strains for the study of human diseases, drug development, and the immune system's response to various pathogens.
-==Advantages and Limitations==
+C57BL/6 mice are known for their distinctive black coat color. They are often used in [[genetic research]] because they have a well-characterized [[genetic background]]. This strain is particularly useful in studies involving [[immunology]], [[oncology]], and [[neuroscience]].
-One of the main advantages of using C57BL/6 mice is the vast amount of comparative data available, due to their long history of use in research. This allows for a high degree of reproducibility and reliability in experimental studies. However, their specific genetic and behavioral characteristics can also be a limitation, as findings in C57BL/6 mice may not always be generalizable to other strains or to humans. Their aggressive behavior can also complicate housing and experimental designs.
-==Conclusion==
+=== Behavior ===
-C57BL/6 mice continue to be a cornerstone of laboratory research across various fields of study. Their extensive use has significantly contributed to our understanding of many biological processes and diseases. Despite some limitations, their role in the advancement of medical and scientific knowledge is undeniable, making them an invaluable resource in the research community.
+C57BL/6 mice are generally more aggressive than other strains, which can be a consideration in [[behavioral studies]]. They are also known for their high levels of [[locomotor activity]] and [[exploratory behavior]].
+=== Health and Disease ===
+This strain is prone to developing [[obesity]], [[diabetes]], and [[atherosclerosis]], making it a valuable model for studying these conditions. C57BL/6 mice are also used in [[cancer research]] due to their susceptibility to [[tumor]] formation.
+== Use in Research ==
+C57BL/6 mice are extensively used in [[transgenic]] and [[knockout mouse]] studies. Their genetic uniformity allows for consistent results across experiments, which is crucial for [[reproducibility]] in scientific research.
+=== Genetic Engineering ===
+The C57BL/6 strain is often used as the background strain for creating [[genetically modified organisms]]. This is because their genome has been fully sequenced, and they are amenable to [[gene editing]] techniques such as [[CRISPR-Cas9]].
+=== Immunological Studies ===
+Due to their well-characterized immune system, C57BL/6 mice are frequently used in [[immunology]] research. They are particularly useful in studies involving [[autoimmune disease]]s and [[vaccine]] development.
+== Related Pages ==
+* [[Laboratory mouse]]
+* [[Inbred strain]]
+* [[Genetic research]]
+* [[Transgenic mouse]]
+* [[Knockout mouse]]
 [[Category:Laboratory mice]]
-{{biology-stub}}
+[[Category:Genetic research]]
+[[Category:Animal models of disease]]