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'''Cilnidipine''' is a [[calcium channel blocker]] used in the | {{Short description|Article about the calcium channel blocker Cilnidipine}} | ||
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'''Cilnidipine''' is a [[calcium channel blocker]] used in the management of [[hypertension]]. It is a dual blocker of L-type and N-type calcium channels, which makes it unique among calcium channel blockers. | |||
==Pharmacology== | ==Pharmacology== | ||
Cilnidipine is a | Cilnidipine is a dihydropyridine calcium channel blocker. It works by inhibiting the influx of calcium ions into vascular smooth muscle and cardiac muscle, leading to vasodilation and a reduction in blood pressure. The dual action on L-type and N-type calcium channels provides additional benefits in terms of reducing sympathetic nerve activity. | ||
===Mechanism of Action=== | |||
Cilnidipine blocks L-type calcium channels, which are primarily found in the [[vascular smooth muscle]] and the heart. This action leads to vasodilation and decreased peripheral resistance. Additionally, cilnidipine blocks N-type calcium channels, which are located in the [[sympathetic nervous system]]. This reduces the release of [[neurotransmitters]] such as [[norepinephrine]], further contributing to its antihypertensive effects. | |||
==Clinical Use== | ==Clinical Use== | ||
Cilnidipine is primarily used | Cilnidipine is primarily used for the treatment of [[hypertension]]. It may be used alone or in combination with other antihypertensive agents. The dual action on both L-type and N-type calcium channels makes it particularly effective in patients with high sympathetic nerve activity. | ||
==Side Effects== | ==Side Effects== | ||
Common side effects of cilnidipine include [[dizziness]], [[flushing]], [[headache]], and [[peripheral edema]]. These are typical of calcium channel blockers due to their vasodilatory effects. Rarely, it may cause [[bradycardia]] or [[hypotension]]. | |||
==Dosage and Administration== | ==Dosage and Administration== | ||
Cilnidipine is | Cilnidipine is administered orally, usually once daily. The dosage may vary based on the patient's response and the severity of hypertension. It is important to follow the prescribing physician's instructions and not to discontinue the medication abruptly. | ||
== | ==Related pages== | ||
* [[Calcium channel blocker]] | * [[Calcium channel blocker]] | ||
* [[Hypertension]] | * [[Hypertension]] | ||
* [[ | * [[Sympathetic nervous system]] | ||
[[Category: | [[Category:Calcium channel blockers]] | ||
[[Category: | [[Category:Antihypertensive agents]] | ||
Revision as of 04:07, 13 February 2025
Article about the calcium channel blocker Cilnidipine
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Cilnidipine is a calcium channel blocker used in the management of hypertension. It is a dual blocker of L-type and N-type calcium channels, which makes it unique among calcium channel blockers.
Pharmacology
Cilnidipine is a dihydropyridine calcium channel blocker. It works by inhibiting the influx of calcium ions into vascular smooth muscle and cardiac muscle, leading to vasodilation and a reduction in blood pressure. The dual action on L-type and N-type calcium channels provides additional benefits in terms of reducing sympathetic nerve activity.
Mechanism of Action
Cilnidipine blocks L-type calcium channels, which are primarily found in the vascular smooth muscle and the heart. This action leads to vasodilation and decreased peripheral resistance. Additionally, cilnidipine blocks N-type calcium channels, which are located in the sympathetic nervous system. This reduces the release of neurotransmitters such as norepinephrine, further contributing to its antihypertensive effects.
Clinical Use
Cilnidipine is primarily used for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents. The dual action on both L-type and N-type calcium channels makes it particularly effective in patients with high sympathetic nerve activity.
Side Effects
Common side effects of cilnidipine include dizziness, flushing, headache, and peripheral edema. These are typical of calcium channel blockers due to their vasodilatory effects. Rarely, it may cause bradycardia or hypotension.
Dosage and Administration
Cilnidipine is administered orally, usually once daily. The dosage may vary based on the patient's response and the severity of hypertension. It is important to follow the prescribing physician's instructions and not to discontinue the medication abruptly.
