ORG-2058: Difference between revisions

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'''ORG-2058''' is a [[synthetic]] [[glucocorticoid]] that was developed by [[Organon International]], a global pharmaceutical company. It is a potent, selective glucocorticoid receptor agonist with anti-inflammatory and immunosuppressive properties.
== Overview ==


== History ==
[[File:ORG-2058.svg|thumb|right|200px|Illustration of the human heart.]]
The human heart is a muscular organ responsible for pumping blood through the [[circulatory system]] by rhythmic contractions. It is located in the [[thoracic cavity]], between the lungs, and is roughly the size of a fist. The heart is a central component of the [[cardiovascular system]], which also includes a vast network of [[blood vessels]] such as [[arteries]], [[veins]], and [[capillaries]].


ORG-2058 was first synthesized in the 1980s by Organon International, a pharmaceutical company based in the [[Netherlands]]. The company was known for its innovative research and development in the field of [[endocrinology]], [[neurology]], and [[reproductive health]].
== Anatomy of the Heart ==


== Pharmacology ==
The heart is divided into four chambers: the left and right [[atria]] and the left and right [[ventricles]]. The atria are the upper chambers that receive blood, while the ventricles are the lower chambers that pump blood out of the heart.


As a synthetic glucocorticoid, ORG-2058 acts on the [[glucocorticoid receptor]], a type of [[nuclear receptor]] that is present inside almost every vertebrate animal cell. Upon binding to the receptor, ORG-2058 exerts its effects by altering the transcription of specific genes, leading to changes in the production of proteins that regulate various biological processes.
=== Right Atrium ===
The right atrium receives deoxygenated blood from the body through the [[superior vena cava]] and [[inferior vena cava]]. It then pumps this blood into the right ventricle.


The primary therapeutic effects of ORG-2058 are its anti-inflammatory and immunosuppressive properties. These effects are achieved through the suppression of inflammatory and immune responses, making ORG-2058 potentially useful in the treatment of conditions such as [[rheumatoid arthritis]], [[asthma]], and [[autoimmune diseases]].
=== Right Ventricle ===
The right ventricle pumps the deoxygenated blood into the [[pulmonary arteries]], which carry it to the lungs for oxygenation.


== Clinical Use ==
=== Left Atrium ===
The left atrium receives oxygenated blood from the lungs via the [[pulmonary veins]]. It then pumps this blood into the left ventricle.


While ORG-2058 has shown promise in preclinical studies, its use in clinical practice is currently limited. Further research is needed to fully understand the potential benefits and risks associated with its use.
=== Left Ventricle ===
The left ventricle is the most muscular chamber of the heart, responsible for pumping oxygenated blood into the [[aorta]] and throughout the body.


== See Also ==
== Heart Valves ==


* [[Glucocorticoid]]
The heart contains four main valves that ensure unidirectional blood flow:
* [[Organon International]]
* [[Glucocorticoid receptor]]
* [[Nuclear receptor]]
* [[Rheumatoid arthritis]]
* [[Asthma]]
* [[Autoimmune diseases]]


[[Category:Pharmaceuticals]]
* The [[tricuspid valve]] is located between the right atrium and right ventricle.
[[Category:Glucocorticoids]]
* The [[pulmonary valve]] is located between the right ventricle and the pulmonary arteries.
[[Category:Organon International]]
* The [[mitral valve]] is located between the left atrium and left ventricle.
{{Pharma-stub}}
* The [[aortic valve]] is located between the left ventricle and the aorta.
 
== Cardiac Cycle ==
 
The cardiac cycle consists of two main phases: [[systole]] and [[diastole]]. During systole, the ventricles contract, pumping blood out of the heart. During diastole, the heart muscle relaxes, allowing the chambers to fill with blood.
 
== Electrical Conduction System ==
 
The heart's rhythmic contractions are controlled by an electrical conduction system. The [[sinoatrial node]] (SA node), located in the right atrium, acts as the natural pacemaker, initiating each heartbeat. The electrical impulse travels through the [[atrioventricular node]] (AV node), down the [[bundle of His]], and through the [[Purkinje fibers]], causing the ventricles to contract.
 
== Related Pages ==
 
* [[Cardiovascular system]]
* [[Blood pressure]]
* [[Electrocardiogram]]
* [[Heart disease]]
 
[[Category:Cardiology]]

Latest revision as of 03:35, 13 February 2025

Overview[edit]

Illustration of the human heart.

The human heart is a muscular organ responsible for pumping blood through the circulatory system by rhythmic contractions. It is located in the thoracic cavity, between the lungs, and is roughly the size of a fist. The heart is a central component of the cardiovascular system, which also includes a vast network of blood vessels such as arteries, veins, and capillaries.

Anatomy of the Heart[edit]

The heart is divided into four chambers: the left and right atria and the left and right ventricles. The atria are the upper chambers that receive blood, while the ventricles are the lower chambers that pump blood out of the heart.

Right Atrium[edit]

The right atrium receives deoxygenated blood from the body through the superior vena cava and inferior vena cava. It then pumps this blood into the right ventricle.

Right Ventricle[edit]

The right ventricle pumps the deoxygenated blood into the pulmonary arteries, which carry it to the lungs for oxygenation.

Left Atrium[edit]

The left atrium receives oxygenated blood from the lungs via the pulmonary veins. It then pumps this blood into the left ventricle.

Left Ventricle[edit]

The left ventricle is the most muscular chamber of the heart, responsible for pumping oxygenated blood into the aorta and throughout the body.

Heart Valves[edit]

The heart contains four main valves that ensure unidirectional blood flow:

  • The tricuspid valve is located between the right atrium and right ventricle.
  • The pulmonary valve is located between the right ventricle and the pulmonary arteries.
  • The mitral valve is located between the left atrium and left ventricle.
  • The aortic valve is located between the left ventricle and the aorta.

Cardiac Cycle[edit]

The cardiac cycle consists of two main phases: systole and diastole. During systole, the ventricles contract, pumping blood out of the heart. During diastole, the heart muscle relaxes, allowing the chambers to fill with blood.

Electrical Conduction System[edit]

The heart's rhythmic contractions are controlled by an electrical conduction system. The sinoatrial node (SA node), located in the right atrium, acts as the natural pacemaker, initiating each heartbeat. The electrical impulse travels through the atrioventricular node (AV node), down the bundle of His, and through the Purkinje fibers, causing the ventricles to contract.

Related Pages[edit]