Prostacyclin receptor

Prostacyclin receptor (also known as IP receptor) is a protein that in humans is encoded by the PTGIR gene. It is a member of the G protein-coupled receptor family and plays a crucial role in the Prostaglandin signaling pathway.

Function

The Prostacyclin receptor is a cell surface receptor that is activated by the binding of Prostacyclin (also known as prostaglandin I2 or PGI2). Prostacyclin is a potent vasodilator and inhibits platelet aggregation. It is synthesized from Arachidonic acid by the action of the Cyclooxygenase enzymes.

Upon activation, the Prostacyclin receptor stimulates an increase in the intracellular concentration of cyclic AMP (cAMP) through the activation of Adenylyl cyclase. This leads to a series of intracellular events that result in the physiological responses associated with Prostacyclin, such as vasodilation and inhibition of platelet aggregation.

Clinical significance

The Prostacyclin receptor is a target for the treatment of pulmonary arterial hypertension (Pulmonary hypertension). Drugs that activate the Prostacyclin receptor, known as Prostacyclin analogs, are used to treat this condition. Examples of these drugs include Epoprostenol, Iloprost, and Treprostinil.

See also

• G protein-coupled receptor
• Prostaglandin
• Pulmonary hypertension

References

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