CEBPG

CEBPG is a gene that encodes a transcription factor in the C/EBP family of proteins. The CEBPG protein is involved in regulating genes in response to hormone stimulation and stress signals. It is expressed in a variety of tissues and plays a key role in immune response, cell differentiation, and apoptosis.

Function

The CEBPG gene encodes a protein that is a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and liver-enriched inhibitory protein (LIP), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis.

Clinical significance

Mutations in the CEBPG gene have been associated with specific medical conditions. For example, a study found that a mutation in this gene was associated with an increased risk of developing acute myeloid leukemia (AML). Further research is needed to confirm these findings and to understand the mechanisms by which CEBPG mutations may contribute to disease development.

See also

• CCAAT-enhancer-binding proteins
• Transcription factor
• Gene expression

References

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