CD38: Difference between revisions

Revision as of 09:05, 10 February 2025

CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4, CD8, B cells and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling.

Function

CD38 is a multifunctional enzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. This molecule is necessary for the regulation of intracellular calcium.

Clinical significance

CD38 has been used as a prognostic marker in leukemia. It is also a target of the drug Daratumumab, which is used in the treatment of multiple myeloma.

References

External links

CD38 at the US National Library of Medicine Medical Subject Headings (MeSH)

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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	This article incorporates text from the [[United States National Library of Medicine]], which is in the public domain.		This article incorporates text from the [[United States National Library of Medicine]], which is in the public domain.
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