Tricaine mesylate: Difference between revisions

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'''Tricaine mesylate''' (also known as '''MS-222''', '''TMS''', or '''Ethyl 3-aminobenzoate methanesulfonate''') is a local anesthetic commonly used in veterinary medicine. It is primarily used for the anesthesia, sedation, and euthanasia of fish and amphibians.
== Tricaine Mesylate ==


==Chemical Structure==
[[File:Tricaine.png|thumb|Tricaine mesylate powder]]
Tricaine mesylate is a white crystalline powder with the chemical formula C9H11NO2·CH4O3S. It is soluble in water and has a pKa of 2.5. The compound is a derivative of [[benzoic acid]] and [[ethanolamine]], and its structure includes an [[amine]] group and a [[benzene ring]].


==Pharmacology==
'''Tricaine mesylate''', also known as '''MS-222''', is a commonly used [[anesthetic]] for [[fish]] and [[amphibians]]. It is a white, crystalline powder that is soluble in water and is used to sedate or euthanize aquatic animals.
Tricaine mesylate acts as a [[sodium channel blocker]], inhibiting the propagation of action potentials in nerve and muscle cells. This results in a loss of sensation, providing effective anesthesia. The drug is rapidly metabolized by the liver, and its effects are reversible upon discontinuation.


==Usage==
== Chemical Properties ==
In veterinary medicine, tricaine mesylate is used for the anesthesia of fish and amphibians. It is the only anesthetic approved by the [[Food and Drug Administration]] (FDA) for use in fish. The drug is also used for the euthanasia of small fish.
Tricaine mesylate is the methanesulfonate salt of [[tricaine]], a compound with the chemical formula C<sub>9</sub>H<sub>11</sub>NO<sub>2</sub>·CH<sub>4</sub>O<sub>3</sub>S. It is a derivative of [[benzocaine]], a local anesthetic, and works by blocking [[sodium channels]] in the [[neurons]] of the animal, preventing the transmission of [[nerve impulses]].


==Side Effects==
== Uses ==
Potential side effects of tricaine mesylate include respiratory depression, cardiac arrhythmias, and death at high doses. It is important to monitor the animal's vital signs during use and to adjust the dosage as necessary.
Tricaine mesylate is primarily used in [[veterinary medicine]] and [[research]] to anesthetize fish and amphibians. It is often used during [[surgery]], [[transport]], and [[handling]] of these animals to reduce stress and pain. The compound is also used for [[euthanasia]] in some cases.


==See Also==
== Administration ==
* [[Local anesthetic]]
Tricaine mesylate is typically administered by dissolving it in water to create an anesthetic bath. The concentration of the solution and the duration of exposure depend on the species and size of the animal, as well as the desired depth of anesthesia. It is important to monitor the animal closely during anesthesia to ensure its safety.
 
== Safety and Regulations ==
Tricaine mesylate is regulated by various governmental agencies, including the [[United States Food and Drug Administration]] (FDA) and the [[European Medicines Agency]] (EMA). It is important to follow proper guidelines and regulations when using tricaine mesylate to ensure the welfare of the animals and compliance with legal standards.
 
== Related Pages ==
* [[Anesthesia]]
* [[Benzocaine]]
* [[Veterinary medicine]]
* [[Veterinary medicine]]
* [[Sodium channel blocker]]
* [[Euthanasia]]
* [[Food and Drug Administration]]
 
==References==
<references />


[[Category:Local anesthetics]]
[[Category:Anesthetics]]
[[Category:Veterinary drugs]]
[[Category:Veterinary medicine]]
[[Category:Sodium channel blockers]]
[[Category:Fishkeeping]]
{{pharmacology-stub}}

Revision as of 11:59, 9 February 2025

Tricaine Mesylate

Tricaine mesylate powder

Tricaine mesylate, also known as MS-222, is a commonly used anesthetic for fish and amphibians. It is a white, crystalline powder that is soluble in water and is used to sedate or euthanize aquatic animals.

Chemical Properties

Tricaine mesylate is the methanesulfonate salt of tricaine, a compound with the chemical formula C9H11NO2·CH4O3S. It is a derivative of benzocaine, a local anesthetic, and works by blocking sodium channels in the neurons of the animal, preventing the transmission of nerve impulses.

Uses

Tricaine mesylate is primarily used in veterinary medicine and research to anesthetize fish and amphibians. It is often used during surgery, transport, and handling of these animals to reduce stress and pain. The compound is also used for euthanasia in some cases.

Administration

Tricaine mesylate is typically administered by dissolving it in water to create an anesthetic bath. The concentration of the solution and the duration of exposure depend on the species and size of the animal, as well as the desired depth of anesthesia. It is important to monitor the animal closely during anesthesia to ensure its safety.

Safety and Regulations

Tricaine mesylate is regulated by various governmental agencies, including the United States Food and Drug Administration (FDA) and the European Medicines Agency (EMA). It is important to follow proper guidelines and regulations when using tricaine mesylate to ensure the welfare of the animals and compliance with legal standards.

Related Pages