IKZF2: Difference between revisions

IKZF2
Symbol	IKZF2
HGNC ID	6070
Alternative symbols	–
Entrez Gene	22807
OMIM	605319
RefSeq	NM_007366
UniProt	Q9UKT9
Chromosome	2q34
Locus supplementary data	–

Latest revision as of 20:49, 30 December 2024

IKZF2 (Ikaros family zinc finger 2) is a gene that encodes a protein belonging to the Ikaros family of transcription factors. This protein is also known as Helios and plays a crucial role in the regulation of lymphocyte development, particularly in T cells.

Function[edit]

The IKZF2 gene is involved in the regulation of gene expression during the development of the immune system. It is specifically expressed in hematopoietic cells and is essential for the proper functioning of T lymphocytes. Helios, the protein encoded by IKZF2, acts as a transcriptional regulator and is involved in the differentiation and proliferation of T cells.

Clinical Significance[edit]

Mutations or dysregulation of the IKZF2 gene have been associated with various immune disorders and cancers. For instance, alterations in IKZF2 expression have been observed in certain types of leukemia and lymphoma. Understanding the role of IKZF2 in these diseases could lead to the development of targeted therapies.

Research[edit]

Ongoing research is focused on elucidating the precise mechanisms by which IKZF2 regulates immune cell development and function. Studies are also investigating the potential of IKZF2 as a biomarker for certain hematological malignancies.

References[edit]

External Links[edit]

@@ Line 1: / Line 1: @@
-'''IKZF2''' (also known as '''Helios''') is a [[transcription factor]] that is encoded by the IKZF2 [[gene]] in humans. It is a member of the Ikaros family of zinc-finger proteins, which play a crucial role in the [[immune system]] and [[hematopoiesis]].
-== Structure ==
+{{Infobox gene
-The IKZF2 gene is located on the q arm of [[chromosome 2]] at position 35. It spans approximately 18.3 kilobases and consists of 8 [[exon]]s. The protein encoded by this gene contains four N-terminal C2H2-type [[zinc finger]] domains, which are involved in DNA binding, and two C-terminal C2H2-type zinc finger domains, which are involved in protein interactions.
+| name = IKZF2
+| image = <!-- Image removed -->
+| caption = <!-- Image caption removed -->
+| HGNCid = 6070
+| symbol = IKZF2
+| alt_symbols = Helios
+| EntrezGene = 22807
+| OMIM = 605319
+| RefSeq = NM_007366
+| UniProt = Q9UKT9
+| chromosome = 2
+| arm = q
+| band = 34
+}}
+'''IKZF2''' (Ikaros family zinc finger 2) is a [[gene]] that encodes a protein belonging to the Ikaros family of [[transcription factors]]. This protein is also known as Helios and plays a crucial role in the regulation of [[lymphocyte]] development, particularly in [[T cells]].
 == Function ==
-IKZF2 is primarily expressed in [[T cell]]s and [[natural killer cell]]s. It plays a critical role in the development and function of these cells. IKZF2 regulates the expression of target genes by binding to specific DNA sequences in their [[promoter region]]s. It is also involved in the regulation of [[cell cycle]] and [[apoptosis]].
+The IKZF2 gene is involved in the regulation of [[gene expression]] during the development of the [[immune system]]. It is specifically expressed in [[hematopoietic cells]] and is essential for the proper functioning of [[T lymphocytes]]. Helios, the protein encoded by IKZF2, acts as a transcriptional regulator and is involved in the differentiation and proliferation of [[T cells]].
-== Clinical significance ==
+== Clinical Significance ==
-Mutations in the IKZF2 gene have been associated with various diseases, including [[autoimmune diseases]] and [[cancer]]. For example, overexpression of IKZF2 has been observed in T-cell acute lymphoblastic leukemia (T-ALL) and is associated with poor prognosis. In contrast, loss of IKZF2 function has been linked to the development of autoimmune diseases such as [[systemic lupus erythematosus]] and [[rheumatoid arthritis]].
+Mutations or dysregulation of the IKZF2 gene have been associated with various [[immune disorders]] and [[cancers]]. For instance, alterations in IKZF2 expression have been observed in certain types of [[leukemia]] and [[lymphoma]]. Understanding the role of IKZF2 in these diseases could lead to the development of targeted therapies.
 == Research ==
-Research is ongoing to better understand the role of IKZF2 in health and disease. For instance, studies are being conducted to investigate the potential of targeting IKZF2 for the treatment of diseases in which it is dysregulated.
+Ongoing research is focused on elucidating the precise mechanisms by which IKZF2 regulates [[immune cell]] development and function. Studies are also investigating the potential of IKZF2 as a [[biomarker]] for certain [[hematological malignancies]].
-[[File:IKZF2 gene location on human chromosome 2.png|thumb|right|300px|Location of the IKZF2 gene on human chromosome 2.]]
-== See also ==
+== See Also ==
-* [[Ikaros family]]
 * [[Transcription factor]]
-* [[Zinc finger]]
+* [[Lymphocyte]]
+* [[Gene expression]]
+* [[Immune system]]
 == References ==
-<references />
+{{Reflist}}
-{{Transcription factors}}
+== External Links ==
-{{Chromosomes}}
+* [https://www.ncbi.nlm.nih.gov/gene/22807 IKZF2 Gene - NCBI]
-{{Genes on human chromosome 2}}
+* [https://www.uniprot.org/uniprot/Q9UKT9 UniProt Entry for IKZF2]
-{{Medicine-stub}}
+[[Category:Genes on human chromosome 2]]
 [[Category:Transcription factors]]
-[[Category:Genes on human chromosome 2]]
+[[Category:Immune system]]
-[[Category:Human proteins]]
-[[Category:Immunology]]
-[[Category:Oncology]]
-[[Category:Rheumatology]]