KLF11: Difference between revisions

KLF11
Symbol	KLF11
HGNC ID	6349
Alternative symbols	–
Entrez Gene	8461
OMIM	603044
RefSeq	NM_003597
UniProt	Q13123
Chromosome	–
Locus supplementary data	–

Latest revision as of 20:47, 30 December 2024

KLF11 (Kruppel-like factor 11) is a protein that in humans is encoded by the KLF11 gene. This gene is a member of the Kruppel-like factor family of transcription factors, which are known to play critical roles in regulating gene expression during cell differentiation and development.

Function[edit]

KLF11 is involved in the regulation of insulin gene expression and has been implicated in the pathogenesis of type 2 diabetes mellitus. It acts as a transcriptional repressor by binding to GC-rich sequences in the promoter regions of target genes. KLF11 has also been shown to interact with histone deacetylases (HDACs), which are involved in chromatin remodeling and gene silencing.

Clinical significance[edit]

Mutations in the KLF11 gene have been associated with an increased risk of developing type 2 diabetes. Studies have shown that certain polymorphisms in the KLF11 gene can affect its ability to regulate insulin gene expression, leading to impaired glucose homeostasis.

Interactions[edit]

KLF11 interacts with several other proteins, including:

These interactions are important for its function as a transcriptional repressor.

Research[edit]

Research on KLF11 continues to explore its role in metabolic diseases and its potential as a therapeutic target. Understanding the molecular mechanisms by which KLF11 regulates gene expression could lead to new strategies for the treatment of diabetes and other related conditions.

References[edit]

External links[edit]

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-'''KLF11''' ('''Krüppel-like factor 11'''), also known as '''TIEG2''' ('''TGF-beta-inducible early growth response protein 2'''), is a protein that in humans is encoded by the KLF11 gene. It is a member of the [[Krüppel-like factor]] family of transcription factors.
+{{Infobox gene
+| name = KLF11
+| symbol = KLF11
+| HGNCid = 6349
+| OMIM = 603044
+| EntrezGene = 8461
+| RefSeq = NM_003597
+| UniProt = Q13123
+}}
+'''KLF11''' (Kruppel-like factor 11) is a protein that in humans is encoded by the '''KLF11''' gene. This gene is a member of the [[Kruppel-like factor]] family of transcription factors, which are known to play critical roles in regulating [[gene expression]] during [[cell differentiation]] and [[development]].
 == Function ==
-KLF11 is a [[transcription factor]] that binds directly to specific recognition motifs in the promoters of target genes and regulates their expression in response to physiological signals. The protein has been shown to interact with [[histone deacetylases]] and repress the transcription of target genes. It also has anti-proliferative effects and can inhibit the growth of human [[pancreatic cancer]] cells.
+KLF11 is involved in the regulation of [[insulin]] gene expression and has been implicated in the pathogenesis of [[type 2 diabetes mellitus]]. It acts as a transcriptional repressor by binding to [[GC-rich sequences]] in the promoter regions of target genes. KLF11 has also been shown to interact with [[histone deacetylases]] (HDACs), which are involved in chromatin remodeling and gene silencing.
 == Clinical significance ==
-Mutations in the KLF11 gene have been associated with [[Type 2 diabetes]] and [[Maturity onset diabetes of the young]] (MODY). The protein is also implicated in the regulation of [[serotonin]] transporter genes and may play a role in [[mood disorders]].
+Mutations in the KLF11 gene have been associated with an increased risk of developing type 2 diabetes. Studies have shown that certain polymorphisms in the KLF11 gene can affect its ability to regulate insulin gene expression, leading to impaired [[glucose homeostasis]].
-== Structure ==
+== Interactions ==
-The KLF11 protein is composed of 598 amino acids and has a molecular weight of approximately 66 kDa. It contains three C2H2-type [[zinc fingers]] at the C-terminus, which are responsible for its DNA-binding activity.
+KLF11 interacts with several other proteins, including:
+* [[Histone deacetylase 1]] (HDAC1)
+* [[Histone deacetylase 3]] (HDAC3)
+* [[Sin3A]]
-== Expression ==
+These interactions are important for its function as a transcriptional repressor.
-KLF11 is expressed in a variety of tissues, including the [[pancreas]], [[brain]], [[kidney]], and [[heart]]. Its expression is regulated by several factors, including [[TGF-beta]] and [[glucose]].
 == Research ==
-Research on KLF11 is ongoing, with studies focusing on its role in diabetes, cancer, and mood disorders. It is also being investigated as a potential therapeutic target for these conditions.
+Research on KLF11 continues to explore its role in metabolic diseases and its potential as a therapeutic target. Understanding the molecular mechanisms by which KLF11 regulates gene expression could lead to new strategies for the treatment of diabetes and other related conditions.
-[[File:KLF11 protein structure.jpg|thumb|right|300px|Structure of the KLF11 protein. Image from Wikimedia Commons.]]
 == See also ==
-* [[Krüppel-like factors]]
 * [[Transcription factor]]
-* [[Type 2 diabetes]]
+* [[Gene regulation]]
-* [[Maturity onset diabetes of the young]]
+* [[Diabetes mellitus]]
-* [[Histone deacetylase]]
 == References ==
 <references />
-{{DEFAULTSORT:KLF11}}
+== External links ==
+* [https://www.ncbi.nlm.nih.gov/gene/8461 KLF11 gene information at NCBI]
+* [https://www.uniprot.org/uniprot/Q13123 KLF11 protein information at UniProt]
 [[Category:Transcription factors]]
 [[Category:Human proteins]]
-[[Category:Genes on human chromosome 2]]
 [[Category:Diabetes]]
-[[Category:Molecular biology]]
-[[Category:Biochemistry]]
-{{medicine-stub}}