GNRHR2: Difference between revisions

GNRHR2
Symbol	GNRHR2
HGNC ID	4410
Alternative symbols	–
Entrez Gene	–
OMIM	–
RefSeq	–
UniProt	–
Chromosome	1q12
Locus supplementary data	–

Latest revision as of 20:40, 30 December 2024

GNRHR2 (Gonadotropin-Releasing Hormone Receptor 2) is a gene that encodes a protein belonging to the G-protein coupled receptor family. This receptor is involved in the hormonal regulation of the reproductive system.

Function[edit]

The GNRHR2 gene is responsible for encoding a receptor that binds to the gonadotropin-releasing hormone (GnRH). This interaction plays a crucial role in the regulation of the pituitary gland, influencing the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These hormones are essential for reproductive health and the functioning of the ovaries and testes.

Expression[edit]

GNRHR2 is expressed in various tissues, including the pituitary gland, hypothalamus, and reproductive organs. Its expression is regulated by hormonal signals and can be influenced by factors such as age, sex, and physiological state.

Clinical Significance[edit]

Mutations or dysregulation of the GNRHR2 gene can lead to disorders of the reproductive system, such as hypogonadotropic hypogonadism, which is characterized by reduced function of the gonads due to insufficient hormonal stimulation. Understanding the role of GNRHR2 in these conditions can aid in the development of targeted therapeutic interventions.

Research[edit]

Ongoing research is focused on elucidating the precise mechanisms by which GNRHR2 influences reproductive health and its potential role in fertility treatments. Studies are also exploring the receptor's involvement in hormone-related cancers and other endocrine disorders.

References[edit]

External Links[edit]

[GNRHR2 at GeneCards](https://www.genecards.org/cgi-bin/carddisp.pl?gene=GNRHR2)
[GNRHR2 at NCBI Gene](https://www.ncbi.nlm.nih.gov/gene/4410)

@@ Line 1: / Line 1: @@
-'''GNRHR2''' is a gene that encodes the [[gonadotropin-releasing hormone (GnRH) receptor]] 2 in humans. This receptor is a member of the [[G-protein coupled receptor]] superfamily. It is activated by the [[gonadotropin-releasing hormone]], which regulates the release of [[gonadotropins]] from the anterior pituitary.
+{{Infobox gene
+| name = GNRHR2
+| symbol = GNRHR2
+| HGNCid = 4410
+| chromosome = 1
+| arm = q
+| band = 12
+}}
+'''GNRHR2''' (Gonadotropin-Releasing Hormone Receptor 2) is a [[gene]] that encodes a protein belonging to the [[G-protein coupled receptor]] family. This receptor is involved in the [[hormonal regulation]] of the [[reproductive system]].
 == Function ==
+The GNRHR2 gene is responsible for encoding a receptor that binds to the [[gonadotropin-releasing hormone]] (GnRH). This interaction plays a crucial role in the regulation of the [[pituitary gland]], influencing the secretion of [[luteinizing hormone]] (LH) and [[follicle-stimulating hormone]] (FSH). These hormones are essential for [[reproductive health]] and the functioning of the [[ovaries]] and [[testes]].
-The GNRHR2 gene is responsible for the production of the GnRH receptor 2. This receptor is primarily found in the [[pituitary gland]], where it plays a crucial role in the regulation of [[reproduction]]. When the GnRH binds to this receptor, it triggers a series of reactions that lead to the release of the gonadotropins: [[luteinizing hormone (LH)]] and [[follicle-stimulating hormone (FSH)]].
+== Expression ==
+GNRHR2 is expressed in various tissues, including the [[pituitary gland]], [[hypothalamus]], and [[reproductive organs]]. Its expression is regulated by [[hormonal signals]] and can be influenced by factors such as [[age]], [[sex]], and [[physiological state]].
-== Clinical significance ==
-Mutations in the GNRHR2 gene can lead to various reproductive disorders. For instance, a loss-of-function mutation can result in [[hypogonadotropic hypogonadism]], a condition characterized by low levels of the sex hormones. On the other hand, a gain-of-function mutation can lead to [[precocious puberty]], a condition where puberty starts too early.
+== Clinical Significance ==
+Mutations or dysregulation of the GNRHR2 gene can lead to disorders of the reproductive system, such as [[hypogonadotropic hypogonadism]], which is characterized by reduced function of the gonads due to insufficient hormonal stimulation. Understanding the role of GNRHR2 in these conditions can aid in the development of targeted [[therapeutic interventions]].
 == Research ==
+Ongoing research is focused on elucidating the precise mechanisms by which GNRHR2 influences reproductive health and its potential role in [[fertility treatments]]. Studies are also exploring the receptor's involvement in [[hormone-related cancers]] and other [[endocrine disorders]].
-Research on the GNRHR2 gene and its encoded receptor is ongoing. Scientists are particularly interested in understanding how mutations in this gene can lead to reproductive disorders. This knowledge could potentially lead to new treatments for these conditions.
+== See Also ==
-[[File:GnRH receptor.png|thumb|right|GnRH receptor, to which GNRHR2 gene encodes.]]
-== See also ==
 * [[Gonadotropin-releasing hormone]]
-* [[Gonadotropin-releasing hormone receptor]]
+* [[Luteinizing hormone]]
-* [[G-protein coupled receptor]]
+* [[Follicle-stimulating hormone]]
 * [[Hypogonadotropic hypogonadism]]
-* [[Precocious puberty]]
 == References ==
+<references/>
-<references />
+== External Links ==
+* [GNRHR2 at GeneCards](https://www.genecards.org/cgi-bin/carddisp.pl?gene=GNRHR2)
-{{GNRHR2}}
+* [GNRHR2 at NCBI Gene](https://www.ncbi.nlm.nih.gov/gene/4410)
-{{Human genes}}
-{{Gonadotropin-releasing hormone and receptors}}
-{{G protein-coupled receptors}}
-{{Reproductive physiology}}
-{{Endocrine system}}
-{{medicine-stub}}
-[[Category:Human genes]]
+[[Category:Genes on human chromosome 1]]
 [[Category:G protein-coupled receptors]]
-[[Category:Endocrine system]]
+[[Category:Reproductive system]]
-[[Category:Reproductive physiology]]