KLF4: Difference between revisions
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== | {{Infobox gene | ||
| name = KLF4 | |||
| image = <!-- Image removed --> | |||
| caption = <!-- Caption removed --> | |||
| HGNCid = 6348 | |||
| symbol = KLF4 | |||
| altSymbols = GKLF | |||
| EntrezGene = 9314 | |||
| OMIM = 602253 | |||
| RefSeq = NM_004235 | |||
| UniProt = O43474 | |||
| chromosome = 9 | |||
| arm = q | |||
| band = 31 | |||
}} | |||
KLF4 | '''KLF4''' (Kruppel-like factor 4) is a [[transcription factor]] that plays a critical role in regulating [[cell differentiation]], [[proliferation]], and [[apoptosis]]. It is a member of the [[Kruppel-like factor]] family of transcription factors, which are characterized by their [[zinc finger]] domains. | ||
== | == Function == | ||
KLF4 is involved in the regulation of [[gene expression]] in various biological processes. It is known to act as both a transcriptional activator and repressor, depending on the context of the target gene and the presence of other cofactors. KLF4 is crucial in maintaining [[stem cell]] pluripotency and is one of the four factors used to generate [[induced pluripotent stem cells]] (iPSCs). | |||
KLF4 is | |||
== Role in Development == | |||
During [[embryonic development]], KLF4 is essential for the proper formation of the [[skin]] and [[gastrointestinal tract]]. It regulates the expression of genes involved in [[epithelial cell]] differentiation and barrier function. | |||
== Clinical Significance == | == Clinical Significance == | ||
KLF4 has been implicated in various [[cancers]], including [[colorectal cancer]], [[breast cancer]], and [[gastric cancer]]. Its role in cancer is complex, as it can function as either a [[tumor suppressor]] or an [[oncogene]] depending on the cellular context. In some cancers, KLF4 expression is downregulated, leading to increased cell proliferation and tumor progression. In others, overexpression of KLF4 can contribute to tumorigenesis. | |||
== Research and Applications == | |||
KLF4 is a subject of extensive research due to its role in [[stem cell biology]] and [[cancer]]. Understanding the mechanisms by which KLF4 regulates gene expression and cell fate decisions is crucial for developing new therapeutic strategies for regenerative medicine and cancer treatment. | |||
== See Also == | == See Also == | ||
* [[Transcription factor]] | * [[Transcription factor]] | ||
* [[ | * [[Stem cell]] | ||
* [[ | * [[Induced pluripotent stem cell]] | ||
* [[Cancer]] | * [[Cancer]] | ||
== References == | == References == | ||
<references /> | <references /> | ||
== External Links == | |||
* [KLF4 at GeneCards](https://www.genecards.org/cgi-bin/carddisp.pl?gene=KLF4) | |||
* [KLF4 at NCBI Gene](https://www.ncbi.nlm.nih.gov/gene/9314) | |||
[[Category:Transcription factors]] | [[Category:Transcription factors]] | ||
[[Category:Stem | [[Category:Stem cell research]] | ||
[[Category: | [[Category:Oncology]] | ||
[[Category: | [[Category:Developmental biology]] | ||
Latest revision as of 20:35, 30 December 2024
| Symbol | KLF4 |
|---|---|
| HGNC ID | 6348 |
| Alternative symbols | – |
| Entrez Gene | 9314 |
| OMIM | 602253 |
| RefSeq | NM_004235 |
| UniProt | O43474 |
| Chromosome | 9q31 |
| Locus supplementary data | – |
KLF4 (Kruppel-like factor 4) is a transcription factor that plays a critical role in regulating cell differentiation, proliferation, and apoptosis. It is a member of the Kruppel-like factor family of transcription factors, which are characterized by their zinc finger domains.
Function[edit]
KLF4 is involved in the regulation of gene expression in various biological processes. It is known to act as both a transcriptional activator and repressor, depending on the context of the target gene and the presence of other cofactors. KLF4 is crucial in maintaining stem cell pluripotency and is one of the four factors used to generate induced pluripotent stem cells (iPSCs).
Role in Development[edit]
During embryonic development, KLF4 is essential for the proper formation of the skin and gastrointestinal tract. It regulates the expression of genes involved in epithelial cell differentiation and barrier function.
Clinical Significance[edit]
KLF4 has been implicated in various cancers, including colorectal cancer, breast cancer, and gastric cancer. Its role in cancer is complex, as it can function as either a tumor suppressor or an oncogene depending on the cellular context. In some cancers, KLF4 expression is downregulated, leading to increased cell proliferation and tumor progression. In others, overexpression of KLF4 can contribute to tumorigenesis.
Research and Applications[edit]
KLF4 is a subject of extensive research due to its role in stem cell biology and cancer. Understanding the mechanisms by which KLF4 regulates gene expression and cell fate decisions is crucial for developing new therapeutic strategies for regenerative medicine and cancer treatment.
See Also[edit]
References[edit]
<references />
External Links[edit]
- [KLF4 at GeneCards](https://www.genecards.org/cgi-bin/carddisp.pl?gene=KLF4)
- [KLF4 at NCBI Gene](https://www.ncbi.nlm.nih.gov/gene/9314)
