S1PR5: Difference between revisions

Latest revision as of 20:22, 30 December 2024

Sphingosine-1-phosphate receptor 5 (S1PR5) is a G protein-coupled receptor that binds the bioactive lipid sphingosine-1-phosphate (S1P). This receptor is part of the sphingosine-1-phosphate receptor family, which plays a crucial role in the regulation of various physiological processes, including immune system function and central nervous system development.

Function[edit]

S1PR5 is primarily expressed in the central nervous system, particularly in oligodendrocytes and microglia. It is involved in the regulation of neuroinflammation and myelination. The receptor mediates the effects of sphingosine-1-phosphate in promoting the survival and differentiation of oligodendrocytes, which are essential for the formation of myelin sheaths around neurons.

Clinical Significance[edit]

Alterations in S1PR5 signaling have been implicated in various neurological disorders, including multiple sclerosis and Alzheimer's disease. Therapeutic targeting of S1PR5 is being explored as a potential strategy for modulating immune responses and promoting neuroprotection in these conditions.

References[edit]

External Links[edit]

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-'''S1PR5''' or '''Sphingosine-1-phosphate receptor 5''' is a [[protein]] that in humans is encoded by the S1PR5 [[gene]]. It is a member of the [[sphingosine-1-phosphate receptor]] family, which is a group of [[G protein-coupled receptors]] that are involved in a variety of cellular processes.
-== Function ==
+{{Infobox protein
-S1PR5 is a receptor for the bioactive lipid [[sphingosine-1-phosphate]] (S1P). S1P is a circulating lipid mediator that regulates a multitude of physiological processes, including [[immune response]], [[cardiovascular development]], and [[lymphocyte trafficking]]. S1PR5 is expressed in various tissues, with high levels in the [[white blood cells]] and [[spleen]].
+| name = Sphingosine-1-phosphate receptor 5
+| image = <!-- Image removed -->
+| caption = <!-- Caption removed -->
+| symbol = S1PR5
+| HGNCid = 14310
+| OMIM = 605276
+| EntrezGene = 53637
+| RefSeq = NM_030760
+| UniProt = Q9H228
+| PDB = <!-- PDB removed -->
+}}
-== Clinical significance ==
+'''Sphingosine-1-phosphate receptor 5''' ('''S1PR5''') is a [[G protein-coupled receptor]] that binds the [[bioactive lipid]] [[sphingosine-1-phosphate]] (S1P). This receptor is part of the [[sphingosine-1-phosphate receptor]] family, which plays a crucial role in the regulation of various physiological processes, including [[immune system]] function and [[central nervous system]] development.
-Alterations in the function of S1PR5 have been implicated in various diseases. For example, it has been suggested that S1PR5 may play a role in the pathogenesis of [[multiple sclerosis]] by regulating the migration of [[lymphocytes]] into the [[central nervous system]]. In addition, S1PR5 has been associated with the progression of [[cancer]], as it can promote the migration and invasion of cancer cells.
-== Research ==
+== Function ==
-Research into the role of S1PR5 in health and disease is ongoing. Current areas of interest include its potential as a therapeutic target in conditions such as [[autoimmune diseases]], [[cancer]], and [[neurodegenerative diseases]].
+S1PR5 is primarily expressed in the [[central nervous system]], particularly in [[oligodendrocytes]] and [[microglia]]. It is involved in the regulation of [[neuroinflammation]] and [[myelination]]. The receptor mediates the effects of sphingosine-1-phosphate in promoting the survival and differentiation of oligodendrocytes, which are essential for the formation of [[myelin]] sheaths around [[neurons]].
-[[File:S1PR5.png|thumb|right|S1PR5 protein structure. Image from Wikimedia Commons.]]
+== Clinical Significance ==
+Alterations in S1PR5 signaling have been implicated in various [[neurological disorders]], including [[multiple sclerosis]] and [[Alzheimer's disease]]. Therapeutic targeting of S1PR5 is being explored as a potential strategy for modulating [[immune responses]] and promoting [[neuroprotection]] in these conditions.
-== See also ==
+== See Also ==
 * [[Sphingosine-1-phosphate receptor]]
 * [[G protein-coupled receptor]]
-* [[Multiple sclerosis]]
+* [[Myelination]]
-* [[Cancer]]
+* [[Neuroinflammation]]
 == References ==
-<references />
+{{Reflist}}
-{{G protein-coupled receptors}}
+== External Links ==
-{{Multiple sclerosis}}
+* [https://www.ncbi.nlm.nih.gov/gene/53637 S1PR5 Gene - NCBI]
-{{Cancer}}
+* [https://www.uniprot.org/uniprot/Q9H228 S1PR5 Protein - UniProt]
-{{medicine-stub}}
 [[Category:G protein-coupled receptors]]
 [[Category:Human proteins]]
-[[Category:Genes]]
+[[Category:Neuroscience]]
-[[Category:Medical terminology]]
+[[Category:Immunology]]
-[[Category:Neurology]]
-[[Category:Oncology]]