Pleuropulmonary blastoma: Difference between revisions
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{{Infobox medical condition | |||
| name = Pleuropulmonary blastoma | |||
| synonyms = PPB | |||
| field = [[Oncology]] | |||
| symptoms = [[Cough]], [[shortness of breath]], [[chest pain]], [[fever]] | |||
| complications = [[Metastasis]], [[pneumothorax]] | |||
| onset = Typically in [[infancy]] or [[early childhood]] | |||
| duration = Variable | |||
| types = Type I, Type II, Type III | |||
| causes = [[Genetic mutations]], often associated with [[DICER1 syndrome]] | |||
| risks = Family history of [[DICER1 syndrome]] | |||
| diagnosis = [[Chest X-ray]], [[CT scan]], [[biopsy]] | |||
| differential = [[Congenital pulmonary airway malformation]], [[bronchogenic cyst]], [[neuroblastoma]] | |||
| treatment = [[Surgery]], [[chemotherapy]], [[radiation therapy]] | |||
| prognosis = Depends on type and stage; generally poorer for Type III | |||
| frequency = Rare | |||
}} | |||
'''Pleuropulmonary blastoma''' (PPB) is a rare and malignant type of [[lung cancer]] that primarily affects children. It is characterized by the presence of [[cyst]]s or solid tumors in the lungs or pleura. | '''Pleuropulmonary blastoma''' (PPB) is a rare and malignant type of [[lung cancer]] that primarily affects children. It is characterized by the presence of [[cyst]]s or solid tumors in the lungs or pleura. | ||
== Signs and Symptoms == | == Signs and Symptoms == | ||
The symptoms of pleuropulmonary blastoma can vary greatly depending on the type and stage of the disease. Common symptoms include a persistent cough, difficulty breathing, chest pain, and recurrent lung infections. In some cases, the disease may be asymptomatic and only discovered during a routine medical examination. | The symptoms of pleuropulmonary blastoma can vary greatly depending on the type and stage of the disease. Common symptoms include a persistent cough, difficulty breathing, chest pain, and recurrent lung infections. In some cases, the disease may be asymptomatic and only discovered during a routine medical examination. | ||
== Causes == | == Causes == | ||
The exact cause of pleuropulmonary blastoma is unknown. However, it is believed to be associated with certain genetic mutations. In particular, mutations in the [[DICER1]] gene have been linked to an increased risk of developing this disease. | The exact cause of pleuropulmonary blastoma is unknown. However, it is believed to be associated with certain genetic mutations. In particular, mutations in the [[DICER1]] gene have been linked to an increased risk of developing this disease. | ||
== Diagnosis == | == Diagnosis == | ||
Diagnosis of pleuropulmonary blastoma typically involves a combination of physical examination, imaging tests such as [[Computed tomography|CT scans]] or [[Magnetic resonance imaging|MRI]], and biopsy. The definitive diagnosis is made by histopathological examination of the tumor tissue. | Diagnosis of pleuropulmonary blastoma typically involves a combination of physical examination, imaging tests such as [[Computed tomography|CT scans]] or [[Magnetic resonance imaging|MRI]], and biopsy. The definitive diagnosis is made by histopathological examination of the tumor tissue. | ||
== Treatment == | == Treatment == | ||
Treatment for pleuropulmonary blastoma usually involves a combination of surgery, chemotherapy, and radiation therapy. The choice of treatment depends on the type and stage of the disease, as well as the patient's overall health. | Treatment for pleuropulmonary blastoma usually involves a combination of surgery, chemotherapy, and radiation therapy. The choice of treatment depends on the type and stage of the disease, as well as the patient's overall health. | ||
== Prognosis == | == Prognosis == | ||
The prognosis for pleuropulmonary blastoma varies widely depending on the type and stage of the disease. Early detection and treatment can significantly improve the prognosis. | The prognosis for pleuropulmonary blastoma varies widely depending on the type and stage of the disease. Early detection and treatment can significantly improve the prognosis. | ||
== See Also == | == See Also == | ||
* [[Lung cancer]] | * [[Lung cancer]] | ||
* [[Pediatric oncology]] | * [[Pediatric oncology]] | ||
* [[DICER1 syndrome]] | * [[DICER1 syndrome]] | ||
== References == | == References == | ||
<references /> | <references /> | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
[[Category:Lung cancer]] | [[Category:Lung cancer]] | ||
Latest revision as of 05:45, 4 April 2025
| Pleuropulmonary blastoma | |
|---|---|
| Synonyms | PPB |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Cough, shortness of breath, chest pain, fever |
| Complications | Metastasis, pneumothorax |
| Onset | Typically in infancy or early childhood |
| Duration | Variable |
| Types | Type I, Type II, Type III |
| Causes | Genetic mutations, often associated with DICER1 syndrome |
| Risks | Family history of DICER1 syndrome |
| Diagnosis | Chest X-ray, CT scan, biopsy |
| Differential diagnosis | Congenital pulmonary airway malformation, bronchogenic cyst, neuroblastoma |
| Prevention | N/A |
| Treatment | Surgery, chemotherapy, radiation therapy |
| Medication | N/A |
| Prognosis | Depends on type and stage; generally poorer for Type III |
| Frequency | Rare |
| Deaths | N/A |
Pleuropulmonary blastoma (PPB) is a rare and malignant type of lung cancer that primarily affects children. It is characterized by the presence of cysts or solid tumors in the lungs or pleura.
Signs and Symptoms[edit]
The symptoms of pleuropulmonary blastoma can vary greatly depending on the type and stage of the disease. Common symptoms include a persistent cough, difficulty breathing, chest pain, and recurrent lung infections. In some cases, the disease may be asymptomatic and only discovered during a routine medical examination.
Causes[edit]
The exact cause of pleuropulmonary blastoma is unknown. However, it is believed to be associated with certain genetic mutations. In particular, mutations in the DICER1 gene have been linked to an increased risk of developing this disease.
Diagnosis[edit]
Diagnosis of pleuropulmonary blastoma typically involves a combination of physical examination, imaging tests such as CT scans or MRI, and biopsy. The definitive diagnosis is made by histopathological examination of the tumor tissue.
Treatment[edit]
Treatment for pleuropulmonary blastoma usually involves a combination of surgery, chemotherapy, and radiation therapy. The choice of treatment depends on the type and stage of the disease, as well as the patient's overall health.
Prognosis[edit]
The prognosis for pleuropulmonary blastoma varies widely depending on the type and stage of the disease. Early detection and treatment can significantly improve the prognosis.
See Also[edit]
References[edit]
<references />
