5-HT2B receptor

5-HT2B receptor is a protein that in humans is encoded by the HTR2B gene. It is a subtype of the 5-HT2 receptor that binds the neurotransmitter serotonin, also known as 5-hydroxytryptamine (5-HT). The 5-HT2B receptor is found in many tissues, including the central nervous system, stomach, and heart.

Function

The 5-HT2B receptor regulates several biological functions. In the brain, it is involved in the regulation of mood and behavior. In the stomach, it regulates gastric motility. In the heart, it plays a role in the regulation of heart rate and force of contraction.

Clinical significance

Mutations in the HTR2B gene have been associated with a variety of disorders, including obesity, schizophrenia, and drug addiction. In addition, certain drugs, such as the weight loss drug fenfluramine, act on the 5-HT2B receptor and can cause heart valve disease.

See also

• 5-HT receptor
• Serotonin
• Neurotransmitter

References

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External links

• 5-HT2B receptor at the IUPHAR Database
• HTR2B at NCBI Gene

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