Enkephalin

Enkephalin is a type of peptide that plays a significant role in regulating pain in the human body. It is one of the many neuropeptides found in the nervous system and is known for its analgesic effect.

Overview

Enkephalins are pentapeptides that are involved in regulating nociception in the body. They are found in the brain and the spinal cord, and are released in response to pain or stress. Enkephalins work by binding to specific opioid receptors in the brain, which in turn reduces the perception of pain.

There are two types of enkephalins: Met-enkephalin and Leu-enkephalin. Both types are derived from a protein known as proenkephalin.

Function

Enkephalins function as neurotransmitters or neuromodulators. As neurotransmitters, they transmit signals across a chemical synapse from one neuron to another 'target' neuron. As neuromodulators, they alter the way in which other neurotransmitters or receptors transmit signals.

Enkephalins are also involved in the body's response to stress and exercise, and they may play a role in mood regulation, immune response, and other physiological functions.

Clinical significance

Research has suggested that enkephalins may play a role in a number of medical conditions, including chronic pain, depression, anxiety, schizophrenia, and Alzheimer's disease. However, more research is needed to fully understand these potential connections.

See also

• Endorphin
• Opioid peptide
• Pain management

References

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Enkephalin

• Met-enkephalin 1plx model
  Met-enkephalin 1plx model