Para-Fluorophenylpiperazine: Difference between revisions

From WikiMD's Wellness Encyclopedia

CSV import
Tags: mobile edit mobile web edit
CSV import
Line 1: Line 1:
'''Para-Fluorophenylpiperazine''' ('''pFPP''') is a [[piperazine]] derivative that is used in scientific research. It is a [[fluorinated]] compound, which means it contains a [[fluorine]] atom. pFPP is known for its [[serotonin receptor]] agonist activity, particularly at the 5-HT1A and 5-HT2A receptors.
{{Short description|Chemical compound}}
{{Chembox
| ImageFile = Para-Fluorophenylpiperazine.png
| ImageSize = 200px
| ImageAlt = Structural formula of para-Fluorophenylpiperazine
| IUPACName = 1-(4-Fluorophenyl)piperazine
| OtherNames = pFPP, 4-FPP
| Section1 = {{Chembox Identifiers
  | CASNo = 38212-30-5
  | PubChem = 100501
  | ChemSpiderID = 90712
  | UNII = 0F3X4Q3XUS
  | SMILES = c1cc(ccc1N2CCNCC2)F
  | InChI = 1S/C10H13FN2/c11-9-1-3-10(4-2-9)13-7-5-12-6-8-13/h1-4,12H,5-8H2
  | InChIKey = YXKTVDFXDRQTKV-UHFFFAOYSA-N
}}
}}


==Chemistry==
==Overview==
'''Para-Fluorophenylpiperazine''' ('''pFPP''') is a chemical compound belonging to the class of [[piperazine]] derivatives. It is structurally related to other phenylpiperazines, which are known for their psychoactive properties. pFPP has been studied for its potential effects on the [[central nervous system]] and is sometimes used in research settings.


Para-Fluorophenylpiperazine is a member of the [[piperazine]] class of compounds. Piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group. This functional group consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring.
==Chemical Structure and Properties==
 
[[File:Para-Fluorophenylpiperazine.png|thumb|right|200px|Structural formula of para-Fluorophenylpiperazine]]
The term "para-fluorophenyl" refers to the specific substitution pattern of the phenyl ring. In this case, the fluorine atom is attached to the phenyl ring at the para position, which is the position directly across from the attachment point of the phenyl ring to the piperazine ring.
The chemical structure of para-Fluorophenylpiperazine consists of a piperazine ring substituted with a para-fluorophenyl group. This substitution pattern is responsible for its unique pharmacological properties. The presence of the fluorine atom in the para position of the phenyl ring influences the compound's interaction with various [[neurotransmitter]] receptors.


==Pharmacology==
==Pharmacology==
Para-Fluorophenylpiperazine acts primarily as a [[serotonin receptor]] agonist, with a particular affinity for the 5-HT1A and 5-HT2A receptors. These interactions are thought to contribute to its psychoactive effects, which can include mood alteration and changes in perception. The compound's activity at these receptors is similar to that of other phenylpiperazines, such as [[mCPP]] and [[TFMPP]].


pFPP acts as a [[serotonin receptor]] agonist. Serotonin receptors are a group of [[G protein-coupled receptor]]s and [[ligand-gated ion channels]] found in the [[central nervous system]] and [[peripheral nervous system]]. They mediate both excitatory and inhibitory neurotransmission. The serotonin receptors are activated by the [[neurotransmitter]] serotonin, which acts as their natural ligand.
==Uses and Applications==
 
While para-Fluorophenylpiperazine is not approved for medical use, it is sometimes utilized in scientific research to study the effects of serotonin receptor agonists. Its ability to modulate serotonin pathways makes it a useful tool in the investigation of [[psychiatric disorders]] and the development of new therapeutic agents.
pFPP has been found to have a high affinity for the 5-HT1A and 5-HT2A receptors. The 5-HT1A receptor is a subtype of serotonin receptor that is thought to play a significant role in [[anxiety]], [[depression]], and [[schizophrenia]]. The 5-HT2A receptor is primarily found in the [[cerebral cortex]] and is thought to play a key role in the cognitive functions of the brain, particularly in [[memory]] and [[learning]].
 
==Research Use==
 
Due to its activity at the serotonin receptors, pFPP is used in scientific research to study the role of these receptors in various neurological and psychiatric disorders. It can be used as a tool to better understand the function of the serotonin system in the brain and how it may be implicated in conditions such as depression, anxiety, and schizophrenia.


==See Also==
==Safety and Legal Status==
The safety profile of para-Fluorophenylpiperazine is not well-established, and its use is generally limited to controlled research environments. In some jurisdictions, it may be classified as a controlled substance due to its potential for abuse and psychoactive effects. Researchers handling pFPP must adhere to appropriate safety protocols to minimize risks.


==Related pages==
* [[Piperazine]]
* [[Piperazine]]
* [[Serotonin receptor]]
* [[Serotonin receptor]]
* [[5-HT1A receptor]]
* [[Phenylpiperazine]]
* [[5-HT2A receptor]]
* [[Psychoactive drug]]


[[Category:Phenylpiperazines]]
[[Category:Serotonin receptor agonists]]
[[Category:Chemical compounds]]
[[Category:Chemical compounds]]
[[Category:Pharmacology]]
[[Category:Neuroscience]]
{{Chem-stub}}
{{Pharma-stub}}
<gallery>
File:Para-Fluorophenylpiperazine PFPP.svg|Para-Fluorophenylpiperazine PFPP structure
File:PFPP3d.png|3D model of PFPP
</gallery>

Revision as of 17:42, 18 February 2025

Chemical compound


Chemical Compound
Identifiers
CAS Number
PubChem CID
ChemSpider ID
UNII
ChEBI
ChEMBL
Properties
Chemical Formula
Molar Mass
Appearance
Density
Melting Point
Boiling Point
Hazards
GHS Pictograms [[File:|50px]]
GHS Signal Word
GHS Hazard Statements
NFPA 704 [[File:|50px]]
References

Overview

Para-Fluorophenylpiperazine (pFPP) is a chemical compound belonging to the class of piperazine derivatives. It is structurally related to other phenylpiperazines, which are known for their psychoactive properties. pFPP has been studied for its potential effects on the central nervous system and is sometimes used in research settings.

Chemical Structure and Properties

File:Para-Fluorophenylpiperazine.png
Structural formula of para-Fluorophenylpiperazine

The chemical structure of para-Fluorophenylpiperazine consists of a piperazine ring substituted with a para-fluorophenyl group. This substitution pattern is responsible for its unique pharmacological properties. The presence of the fluorine atom in the para position of the phenyl ring influences the compound's interaction with various neurotransmitter receptors.

Pharmacology

Para-Fluorophenylpiperazine acts primarily as a serotonin receptor agonist, with a particular affinity for the 5-HT1A and 5-HT2A receptors. These interactions are thought to contribute to its psychoactive effects, which can include mood alteration and changes in perception. The compound's activity at these receptors is similar to that of other phenylpiperazines, such as mCPP and TFMPP.

Uses and Applications

While para-Fluorophenylpiperazine is not approved for medical use, it is sometimes utilized in scientific research to study the effects of serotonin receptor agonists. Its ability to modulate serotonin pathways makes it a useful tool in the investigation of psychiatric disorders and the development of new therapeutic agents.

Safety and Legal Status

The safety profile of para-Fluorophenylpiperazine is not well-established, and its use is generally limited to controlled research environments. In some jurisdictions, it may be classified as a controlled substance due to its potential for abuse and psychoactive effects. Researchers handling pFPP must adhere to appropriate safety protocols to minimize risks.

Related pages