Ganglioneuroblastoma: Difference between revisions
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{{Infobox medical condition | |||
[[File:Neck_mass.jpg| | | name = Ganglioneuroblastoma | ||
| image = [[File:Neck_mass.jpg|250px]] | |||
| caption = Ganglioneuroblastoma presenting as a neck mass | |||
| field = [[Oncology]] | |||
| symptoms = [[Abdominal pain]], [[constipation]], [[hypertension]], [[palpable mass]] | |||
| complications = [[Metastasis]], [[spinal cord compression]] | |||
| onset = Typically in [[children]] | |||
| duration = Variable | |||
| types = [[Nodular]], [[intermixed]] | |||
| causes = Unknown | |||
| risks = [[Genetic predisposition]], [[neurofibromatosis type I]] | |||
| diagnosis = [[Biopsy]], [[imaging studies]] | |||
| differential = [[Neuroblastoma]], [[ganglioneuroma]] | |||
| prevention = None | |||
| treatment = [[Surgery]], [[chemotherapy]], [[radiation therapy]] | |||
| medication = [[Chemotherapeutic agents]] | |||
| prognosis = Variable, depends on stage and histology | |||
| frequency = Rare | |||
| deaths = Dependent on stage and treatment response | |||
}} | |||
'''Ganglioneuroblastoma''' is a rare type of [[tumor]] that arises from the [[sympathetic nervous system]]. It is considered an intermediate tumor between [[neuroblastoma]] and [[ganglioneuroma]], containing both malignant and benign components. This tumor is most commonly found in children and can occur in various parts of the body, including the [[adrenal glands]], [[neck]], [[chest]], and [[abdomen]]. | '''Ganglioneuroblastoma''' is a rare type of [[tumor]] that arises from the [[sympathetic nervous system]]. It is considered an intermediate tumor between [[neuroblastoma]] and [[ganglioneuroma]], containing both malignant and benign components. This tumor is most commonly found in children and can occur in various parts of the body, including the [[adrenal glands]], [[neck]], [[chest]], and [[abdomen]]. | ||
== Pathophysiology == | == Pathophysiology == | ||
Ganglioneuroblastoma originates from [[neural crest cells]], which are embryonic cells that give rise to the [[sympathetic nervous system]]. These tumors contain a mixture of mature ganglion cells and immature neuroblasts. The presence of both cell types distinguishes ganglioneuroblastoma from other neuroblastic tumors. | Ganglioneuroblastoma originates from [[neural crest cells]], which are embryonic cells that give rise to the [[sympathetic nervous system]]. These tumors contain a mixture of mature ganglion cells and immature neuroblasts. The presence of both cell types distinguishes ganglioneuroblastoma from other neuroblastic tumors. | ||
== Clinical Presentation == | == Clinical Presentation == | ||
Patients with ganglioneuroblastoma may present with a variety of symptoms depending on the location of the tumor. Common symptoms include: | Patients with ganglioneuroblastoma may present with a variety of symptoms depending on the location of the tumor. Common symptoms include: | ||
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* [[Horner's syndrome]] if the tumor affects the sympathetic chain in the neck | * [[Horner's syndrome]] if the tumor affects the sympathetic chain in the neck | ||
* [[Hypertension]] due to catecholamine secretion by the tumor | * [[Hypertension]] due to catecholamine secretion by the tumor | ||
== Diagnosis == | == Diagnosis == | ||
The diagnosis of ganglioneuroblastoma typically involves a combination of imaging studies and biopsy. Imaging techniques such as [[CT scan]] and [[MRI]] are used to assess the size and location of the tumor. A biopsy is necessary to confirm the diagnosis and to differentiate ganglioneuroblastoma from other similar tumors. | The diagnosis of ganglioneuroblastoma typically involves a combination of imaging studies and biopsy. Imaging techniques such as [[CT scan]] and [[MRI]] are used to assess the size and location of the tumor. A biopsy is necessary to confirm the diagnosis and to differentiate ganglioneuroblastoma from other similar tumors. | ||
== Treatment == | == Treatment == | ||
Treatment for ganglioneuroblastoma depends on the stage and location of the tumor. Options may include: | Treatment for ganglioneuroblastoma depends on the stage and location of the tumor. Options may include: | ||
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* [[Chemotherapy]] to target malignant cells | * [[Chemotherapy]] to target malignant cells | ||
* [[Radiation therapy]] in certain cases | * [[Radiation therapy]] in certain cases | ||
== Prognosis == | == Prognosis == | ||
The prognosis for ganglioneuroblastoma varies based on factors such as the age of the patient, the stage of the tumor, and the presence of metastasis. Generally, the prognosis is better than that of neuroblastoma but worse than that of ganglioneuroma. | The prognosis for ganglioneuroblastoma varies based on factors such as the age of the patient, the stage of the tumor, and the presence of metastasis. Generally, the prognosis is better than that of neuroblastoma but worse than that of ganglioneuroma. | ||
== See also == | |||
== | |||
* [[Neuroblastoma]] | * [[Neuroblastoma]] | ||
* [[Ganglioneuroma]] | * [[Ganglioneuroma]] | ||
* [[Sympathetic nervous system]] | * [[Sympathetic nervous system]] | ||
* [[Neural crest]] | * [[Neural crest]] | ||
[[Category:Neoplasms]] | [[Category:Neoplasms]] | ||
[[Category:Pediatric cancers]] | [[Category:Pediatric cancers]] | ||
Latest revision as of 01:51, 7 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Ganglioneuroblastoma | |
|---|---|
| |
| Synonyms | N/A |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Abdominal pain, constipation, hypertension, palpable mass |
| Complications | Metastasis, spinal cord compression |
| Onset | Typically in children |
| Duration | Variable |
| Types | Nodular, intermixed |
| Causes | Unknown |
| Risks | Genetic predisposition, neurofibromatosis type I |
| Diagnosis | Biopsy, imaging studies |
| Differential diagnosis | Neuroblastoma, ganglioneuroma |
| Prevention | None |
| Treatment | Surgery, chemotherapy, radiation therapy |
| Medication | Chemotherapeutic agents |
| Prognosis | Variable, depends on stage and histology |
| Frequency | Rare |
| Deaths | Dependent on stage and treatment response |
Ganglioneuroblastoma is a rare type of tumor that arises from the sympathetic nervous system. It is considered an intermediate tumor between neuroblastoma and ganglioneuroma, containing both malignant and benign components. This tumor is most commonly found in children and can occur in various parts of the body, including the adrenal glands, neck, chest, and abdomen.
Pathophysiology[edit]
Ganglioneuroblastoma originates from neural crest cells, which are embryonic cells that give rise to the sympathetic nervous system. These tumors contain a mixture of mature ganglion cells and immature neuroblasts. The presence of both cell types distinguishes ganglioneuroblastoma from other neuroblastic tumors.
Clinical Presentation[edit]
Patients with ganglioneuroblastoma may present with a variety of symptoms depending on the location of the tumor. Common symptoms include:
- A palpable mass in the neck, chest, or abdomen
- Pain or discomfort in the affected area
- Horner's syndrome if the tumor affects the sympathetic chain in the neck
- Hypertension due to catecholamine secretion by the tumor
Diagnosis[edit]
The diagnosis of ganglioneuroblastoma typically involves a combination of imaging studies and biopsy. Imaging techniques such as CT scan and MRI are used to assess the size and location of the tumor. A biopsy is necessary to confirm the diagnosis and to differentiate ganglioneuroblastoma from other similar tumors.
Treatment[edit]
Treatment for ganglioneuroblastoma depends on the stage and location of the tumor. Options may include:
- Surgical resection to remove the tumor
- Chemotherapy to target malignant cells
- Radiation therapy in certain cases
Prognosis[edit]
The prognosis for ganglioneuroblastoma varies based on factors such as the age of the patient, the stage of the tumor, and the presence of metastasis. Generally, the prognosis is better than that of neuroblastoma but worse than that of ganglioneuroma.
