Diacetyldihydromorphine: Difference between revisions
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{{DISPLAYTITLE:Diacetyldihydromorphine}} | {{DISPLAYTITLE:Diacetyldihydromorphine}} | ||
'''Diacetyldihydromorphine''', also known as '''dihydroheroin''', is a semi-synthetic opioid derived from [[morphine]]. It is an acetylated form of [[dihydromorphine]], similar in structure to [[heroin]] (diacetylmorphine), but with a saturated 7,8-dihydro ring. | '''Diacetyldihydromorphine''', also known as '''dihydroheroin''', is a semi-synthetic opioid derived from [[morphine]]. It is an acetylated form of [[dihydromorphine]], similar in structure to [[heroin]] (diacetylmorphine), but with a saturated 7,8-dihydro ring. | ||
Revision as of 20:02, 15 February 2025
Diacetyldihydromorphine, also known as dihydroheroin, is a semi-synthetic opioid derived from morphine. It is an acetylated form of dihydromorphine, similar in structure to heroin (diacetylmorphine), but with a saturated 7,8-dihydro ring.
Chemical Properties
Diacetyldihydromorphine is chemically classified as an opioid and is a member of the morphinan class of compounds. The chemical structure of diacetyldihydromorphine is characterized by the presence of two acetyl groups attached to the morphinan skeleton, specifically at the 3 and 6 positions of the morphine molecule. This modification increases its lipid solubility, allowing it to cross the blood-brain barrier more efficiently than morphine.
Pharmacology
Diacetyldihydromorphine acts primarily as an agonist at the mu-opioid receptor, similar to other opioids. This receptor is responsible for the analgesic and euphoric effects of opioids. The acetylation of dihydromorphine to form diacetyldihydromorphine enhances its potency and duration of action compared to its parent compound.
Effects
The effects of diacetyldihydromorphine are similar to those of other opioids, including:
- Analgesia (pain relief)
- Euphoria
- Sedation
- Respiratory depression
- Constipation
Metabolism
Once administered, diacetyldihydromorphine is rapidly metabolized in the body. It is deacetylated to form dihydromorphine, which is then further metabolized and excreted. The rapid metabolism contributes to its short duration of action.
Medical Use
Diacetyldihydromorphine has been used in the past for its analgesic properties, but its use is limited due to the potential for abuse and addiction. It is not commonly used in modern medical practice and is classified as a controlled substance in many countries.
Legal Status
Due to its potential for abuse and addiction, diacetyldihydromorphine is classified as a Schedule I controlled substance in the United States, meaning it is not accepted for medical use and has a high potential for abuse. Similar restrictions apply in other countries under international drug control treaties.
