AB-PINACA: Difference between revisions

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{{Short description|Synthetic cannabinoid}}
{{DISPLAYTITLE:AB-PINACA}}
{{Drugbox
| verifiedfields = changed
| verifiedrevid = 477002547
| IUPAC_name = N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide
| image = AB-PINACA_structure-rev1.png
| width = 200
}}


'''AB-PINACA''' is a synthetic cannabinoid that acts as a potent agonist of the [[cannabinoid receptor]]s. It was originally developed by Pfizer in 2009 as an analgesic medication, but it has since become a substance of abuse in various parts of the world.
== Overview ==
'''AB-PINACA''' is a synthetic cannabinoid that acts as a potent agonist of the [[cannabinoid receptor]]s. It was originally developed by Pfizer in 2009 as part of a series of compounds related to [[AM-2201]]. AB-PINACA has been identified in synthetic cannabis products and is known for its psychoactive effects.


==Chemical structure==
== Chemical Structure ==
AB-PINACA is classified as an indazole-based synthetic cannabinoid. Its chemical structure is characterized by a 1-pentyl-1H-indazole core with a carboxamide group at the 3-position and an amino acid amide group at the 1-position. The IUPAC name for AB-PINACA is N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide.
[[File:AB-PINACA_structure-rev1.png|thumb|right|Chemical structure of AB-PINACA]]
AB-PINACA is chemically classified as an indazole-based synthetic cannabinoid. Its full chemical name is N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide. The structure consists of an indazole core with a carboxamide group at the 3-position and a pentyl chain at the 1-position.


==Pharmacology==
== Pharmacology ==
AB-PINACA acts as a full agonist at the [[CB1 receptor|CB<sub>1</sub>]] and [[CB2 receptor|CB<sub>2</sub>]] cannabinoid receptors. These receptors are part of the [[endocannabinoid system]], which plays a role in regulating various physiological processes including pain sensation, mood, and appetite. The activation of these receptors by AB-PINACA can lead to psychoactive effects similar to those of [[tetrahydrocannabinol]] (THC), the active component of [[cannabis]].
AB-PINACA acts as a full agonist at the [[CB1 receptor|CB1]] and [[CB2 receptor|CB2]] cannabinoid receptors, which are part of the [[endocannabinoid system]]. This system is involved in regulating various physiological processes including mood, memory, and pain sensation. The activation of these receptors by AB-PINACA leads to its psychoactive effects.


==Effects==
== Effects and Toxicity ==
The effects of AB-PINACA are similar to those of other synthetic cannabinoids and can include euphoria, relaxation, altered perception, and increased appetite. However, it can also cause adverse effects such as anxiety, paranoia, tachycardia, and in some cases, severe health complications like seizures or [[psychosis]].
The effects of AB-PINACA are similar to those of other synthetic cannabinoids, including euphoria, altered perception, and relaxation. However, it can also cause adverse effects such as anxiety, paranoia, and in some cases, severe toxicity. Overdose symptoms may include [[tachycardia]], [[hypertension]], and [[hallucinations]].


==Legal status==
== Legal Status ==
Due to its potential for abuse and adverse health effects, AB-PINACA has been classified as a controlled substance in many countries. In the United States, it is listed as a Schedule I substance under the [[Controlled Substances Act]], indicating that it is considered to have a high potential for abuse and no accepted medical use.
Due to its potential for abuse and lack of medical use, AB-PINACA has been classified as a Schedule I controlled substance in many countries. This classification indicates that it is illegal to manufacture, distribute, or possess without a license.


==Synthesis==
== Related Compounds ==
The synthesis of AB-PINACA involves the reaction of 1-pentyl-1H-indazole-3-carboxylic acid with an appropriate amine to form the carboxamide linkage. The specific synthetic routes can vary, but they generally involve standard organic synthesis techniques used in the preparation of indazole derivatives.
AB-PINACA is part of a larger class of synthetic cannabinoids, which includes compounds such as [[JWH-018]], [[AM-2201]], and [[UR-144]]. These compounds are often used in the production of synthetic cannabis products, commonly known as "spice" or "K2."


==Health risks==
== Related Pages ==
The use of AB-PINACA has been associated with numerous health risks, particularly when used in high doses or in combination with other substances. Users may experience severe cardiovascular, neurological, and psychological effects. There have been reports of hospitalizations and fatalities linked to its use.
 
==Related pages==
* [[Synthetic cannabinoids]]
* [[Synthetic cannabinoids]]
* [[Cannabinoid receptor]]
* [[Cannabinoid receptor]]
* [[Endocannabinoid system]]
* [[Endocannabinoid system]]
* [[Controlled Substances Act]]
* [[AM-2201]]


[[Category:Synthetic cannabinoids]]
[[Category:Synthetic cannabinoids]]
[[Category:Designer drugs]]
[[Category:Designer drugs]]
[[Category:Indazolecarboxamides]]

Latest revision as of 11:22, 15 February 2025


Overview[edit]

AB-PINACA is a synthetic cannabinoid that acts as a potent agonist of the cannabinoid receptors. It was originally developed by Pfizer in 2009 as part of a series of compounds related to AM-2201. AB-PINACA has been identified in synthetic cannabis products and is known for its psychoactive effects.

Chemical Structure[edit]

Chemical structure of AB-PINACA

AB-PINACA is chemically classified as an indazole-based synthetic cannabinoid. Its full chemical name is N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide. The structure consists of an indazole core with a carboxamide group at the 3-position and a pentyl chain at the 1-position.

Pharmacology[edit]

AB-PINACA acts as a full agonist at the CB1 and CB2 cannabinoid receptors, which are part of the endocannabinoid system. This system is involved in regulating various physiological processes including mood, memory, and pain sensation. The activation of these receptors by AB-PINACA leads to its psychoactive effects.

Effects and Toxicity[edit]

The effects of AB-PINACA are similar to those of other synthetic cannabinoids, including euphoria, altered perception, and relaxation. However, it can also cause adverse effects such as anxiety, paranoia, and in some cases, severe toxicity. Overdose symptoms may include tachycardia, hypertension, and hallucinations.

Legal Status[edit]

Due to its potential for abuse and lack of medical use, AB-PINACA has been classified as a Schedule I controlled substance in many countries. This classification indicates that it is illegal to manufacture, distribute, or possess without a license.

Related Compounds[edit]

AB-PINACA is part of a larger class of synthetic cannabinoids, which includes compounds such as JWH-018, AM-2201, and UR-144. These compounds are often used in the production of synthetic cannabis products, commonly known as "spice" or "K2."

Related Pages[edit]