Valsartan/hydrochlorothiazide

Valsartan/hydrochlorothiazide

Chemical structure of Valsartan

Chemical structure of Hydrochlorothiazide

Valsartan/hydrochlorothiazide is a combination medication used to treat hypertension (high blood pressure). It combines two active ingredients: valsartan, an angiotensin II receptor antagonist, and hydrochlorothiazide, a thiazide diuretic.

Medical uses

Valsartan/hydrochlorothiazide is primarily prescribed for the management of hypertension. By lowering blood pressure, it helps to prevent strokes, heart attacks, and kidney problems. The combination of valsartan and hydrochlorothiazide works by relaxing blood vessels and reducing the amount of water and salt in the body.

Mechanism of action

Valsartan works by blocking the effects of angiotensin II, a substance in the body that causes blood vessels to tighten and narrow. By blocking this action, valsartan helps to relax and widen blood vessels, which lowers blood pressure.

Hydrochlorothiazide is a diuretic that helps prevent the body from absorbing too much salt, which can cause fluid retention. It increases the amount of urine passed, which helps to lower blood pressure.

Side effects

Common side effects of valsartan/hydrochlorothiazide include dizziness, lightheadedness, and dehydration. Serious side effects may include fainting, muscle weakness, and changes in the amount of urine. Patients are advised to report any severe side effects to their healthcare provider.

Contraindications

Valsartan/hydrochlorothiazide is contraindicated in patients with anuria or hypersensitivity to any component of the product. It should not be used during pregnancy as it can harm the fetus.

Interactions

This medication may interact with other drugs, including lithium, NSAIDs, and other blood pressure medications. Patients should inform their healthcare provider of all medications they are taking to avoid potential interactions.

Related pages

• Valsartan
• Hydrochlorothiazide
• Hypertension
• Angiotensin II receptor antagonist
• Thiazide diuretic

References

• 
  Chemical structure of Valsartan
• 
  Chemical structure of Hydrochlorothiazide
• 
  Leukotriene B4 hydroxylation pathway