Dimazole: Difference between revisions
CSV import |
CSV import |
||
| Line 1: | Line 1: | ||
{{DISPLAYTITLE:Dimazole}} | |||
== | == Overview == | ||
Dimazole | '''Dimazole''' is an [[antifungal]] medication used primarily in the treatment of [[fungal infections]]. It belongs to the class of [[imidazole]] antifungals, which work by inhibiting the synthesis of [[ergosterol]], an essential component of fungal cell membranes. | ||
== | == Mechanism of Action == | ||
Dimazole functions by disrupting the production of ergosterol, a critical component of the fungal cell membrane. By inhibiting the enzyme [[lanosterol 14_-demethylase]], dimazole prevents the conversion of lanosterol to ergosterol, leading to increased membrane permeability and ultimately cell death. | |||
== | == Clinical Uses == | ||
Dimazole is indicated for the | Dimazole is indicated for the treatment of various fungal infections, including: | ||
* [[ | * [[Candidiasis]] | ||
* [[ | * [[Dermatophytosis]] | ||
* | * [[Tinea versicolor]] | ||
It is available in several formulations, including topical creams, oral tablets, and intravenous solutions, depending on the severity and location of the infection. | |||
== Side Effects == | |||
* | Common side effects of dimazole include: | ||
* | * [[Nausea]] | ||
* | * [[Headache]] | ||
* [[Rash]] | |||
Patients are advised to | Serious side effects, though rare, may include [[hepatotoxicity]] and [[anaphylaxis]]. Patients are advised to report any unusual symptoms to their healthcare provider. | ||
== | == Pharmacokinetics == | ||
Dimazole | Dimazole is well absorbed when administered orally, with peak plasma concentrations occurring within 1-2 hours. It is metabolized in the [[liver]] and excreted primarily in the [[urine]]. | ||
== | == Contraindications == | ||
Dimazole | Dimazole is contraindicated in patients with known hypersensitivity to imidazole antifungals. Caution is advised in patients with [[liver disease]] due to the potential for hepatotoxicity. | ||
== Related Pages == | |||
* [[Antifungal]] | |||
* [[Imidazole]] | |||
* [[Ergosterol]] | |||
== | == Gallery == | ||
Dimazole | [[File:Dimazole.svg|thumb|right|Chemical structure of Dimazole]] | ||
[[Category: | [[Category:Antifungal agents]] | ||
[[Category: | [[Category:Imidazole antifungals]] | ||
Latest revision as of 03:42, 13 February 2025
Overview[edit]
Dimazole is an antifungal medication used primarily in the treatment of fungal infections. It belongs to the class of imidazole antifungals, which work by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes.
Mechanism of Action[edit]
Dimazole functions by disrupting the production of ergosterol, a critical component of the fungal cell membrane. By inhibiting the enzyme lanosterol 14_-demethylase, dimazole prevents the conversion of lanosterol to ergosterol, leading to increased membrane permeability and ultimately cell death.
Clinical Uses[edit]
Dimazole is indicated for the treatment of various fungal infections, including:
It is available in several formulations, including topical creams, oral tablets, and intravenous solutions, depending on the severity and location of the infection.
Side Effects[edit]
Common side effects of dimazole include:
Serious side effects, though rare, may include hepatotoxicity and anaphylaxis. Patients are advised to report any unusual symptoms to their healthcare provider.
Pharmacokinetics[edit]
Dimazole is well absorbed when administered orally, with peak plasma concentrations occurring within 1-2 hours. It is metabolized in the liver and excreted primarily in the urine.
Contraindications[edit]
Dimazole is contraindicated in patients with known hypersensitivity to imidazole antifungals. Caution is advised in patients with liver disease due to the potential for hepatotoxicity.
