Cefpimizole: Difference between revisions

Cefpimizole
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Revision as of 03:58, 13 February 2025

An article about the antibiotic Cefpimizole

Cefpimizole is a cephalosporin antibiotic used in the treatment of various bacterial infections. It belongs to the class of beta-lactam antibiotics, which are known for their broad-spectrum activity against both Gram-positive and Gram-negative bacteria.

Mechanism of Action

Cefpimizole works by inhibiting bacterial cell wall synthesis. It binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which leads to the interruption of peptidoglycan synthesis. This results in the weakening of the cell wall and ultimately causes bacterial cell lysis and death.

Pharmacokinetics

Cefpimizole is administered intravenously or intramuscularly. After administration, it is distributed widely throughout the body, including into tissues and fluids. The drug is primarily excreted unchanged in the urine, which makes it effective for treating urinary tract infections.

Clinical Uses

Cefpimizole is used to treat a variety of infections, including:

Side Effects

Common side effects of cefpimizole include:

Gastrointestinal disturbances such as nausea and diarrhea
Allergic reactions, including rash and pruritus
Hematological effects such as neutropenia and thrombocytopenia

Resistance

Bacterial resistance to cefpimizole can occur through several mechanisms, including the production of beta-lactamases, which can hydrolyze the beta-lactam ring of the antibiotic, rendering it ineffective. Resistance can also occur through alterations in PBPs or decreased permeability of the bacterial cell wall.

Related pages

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-'''Cefpimizole''' is a broad-spectrum [[antibiotic]] belonging to the third generation of the [[cephalosporin]] class. It is designed to combat a wide range of bacterial infections, particularly those caused by gram-positive and gram-negative organisms. Cefpimizole works by inhibiting the synthesis of the bacterial cell wall, leading to the death of the bacteria. This mechanism is similar to other cephalosporins, making it effective against organisms that are susceptible to this class of antibiotics.
+{{Short description|An article about the antibiotic Cefpimizole}}
+{{Drugbox
+| verifiedrevid = 477241123
+| image = Cefpimizole.svg
+| image2 = <!-- Another image if available -->
+}}
-==Indications==
+'''Cefpimizole''' is a [[cephalosporin]] [[antibiotic]] used in the treatment of various bacterial infections. It belongs to the class of beta-lactam antibiotics, which are known for their broad-spectrum activity against both Gram-positive and Gram-negative bacteria.
-Cefpimizole is indicated for the treatment of various bacterial infections, including but not limited to:
-* [[Pneumonia]]
-* [[Urinary tract infection]]s (UTIs)
-* [[Skin and soft tissue infection]]s
-* [[Sepsis]] and septicemia
-* Infections caused by susceptible strains of bacteria, such as [[Staphylococcus aureus]], [[Escherichia coli]], and [[Klebsiella pneumoniae]].
-==Pharmacology==
+==Mechanism of Action==
-The pharmacological action of Cefpimizole involves the inhibition of bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby disrupting the final transpeptidation step of peptidoglycan synthesis. This leads to weakening of the cell wall and ultimately causes cell lysis and death.
+Cefpimizole works by inhibiting bacterial [[cell wall]] synthesis. It binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which leads to the interruption of peptidoglycan synthesis. This results in the weakening of the cell wall and ultimately causes bacterial cell lysis and death.
-==Administration==
+==Pharmacokinetics==
-Cefpimizole is administered intravenously. The dosage and duration of treatment depend on the type and severity of the infection, as well as the patient's age, weight, and renal function.
+Cefpimizole is administered intravenously or intramuscularly. After administration, it is distributed widely throughout the body, including into tissues and fluids. The drug is primarily excreted unchanged in the urine, which makes it effective for treating urinary tract infections.
+==Clinical Uses==
+Cefpimizole is used to treat a variety of infections, including:
+* [[Respiratory tract infections]]
+* [[Urinary tract infections]]
+* [[Skin and soft tissue infections]]
+* [[Intra-abdominal infections]]
 ==Side Effects==
-As with all medications, Cefpimizole may cause side effects in some patients. Common side effects include:
+Common side effects of cefpimizole include:
-* [[Nausea]] and [[vomiting]]
+* [[Gastrointestinal disturbances]] such as nausea and diarrhea
-* [[Diarrhea]]
+* [[Allergic reactions]], including rash and pruritus
-* [[Rash]]
+* [[Hematological effects]] such as neutropenia and thrombocytopenia
-* Changes in liver enzyme levels
-* [[Allergic reactions]], including anaphylaxis in rare cases
-Patients should be monitored for signs of an allergic reaction, and any severe or persistent side effects should be reported to a healthcare provider.
-==Drug Interactions==
-Cefpimizole may interact with other medications, potentially altering their effects. It is important to inform the healthcare provider of all medications being taken, including over-the-counter drugs and supplements. Particular caution should be exercised when using Cefpimizole in conjunction with other antibiotics or medications known to affect renal function.
-==Contraindications==
+==Resistance==
-Cefpimizole is contraindicated in patients with a known allergy to cephalosporin antibiotics. Caution is advised in patients with a history of [[allergy]] to penicillins, as cross-reactivity may occur.
+Bacterial resistance to cefpimizole can occur through several mechanisms, including the production of beta-lactamases, which can hydrolyze the beta-lactam ring of the antibiotic, rendering it ineffective. Resistance can also occur through alterations in PBPs or decreased permeability of the bacterial cell wall.
-==Conclusion==
+==Related pages==
-Cefpimizole is a valuable antibiotic in the treatment of a wide range of bacterial infections. Its broad-spectrum activity and safety profile make it a useful option in the arsenal against bacterial diseases. However, like all antibiotics, it should be used judiciously to prevent the development of resistance.
+* [[Cephalosporin]]
+* [[Antibiotic resistance]]
+* [[Beta-lactam antibiotic]]
-[[Category:Antibiotics]]
 [[Category:Cephalosporin antibiotics]]
-[[Category:Pharmacology]]
+[[Category:Beta-lactam antibiotics]]
-{{Medicine-stub}}