P2RY8: Difference between revisions

P2RY8
Symbol	P2RY8
HGNC ID	15566
Alternative symbols	–
Entrez Gene	–
OMIM	–
RefSeq	–
UniProt	–
Chromosome	Xp11.4
Locus supplementary data	–

Latest revision as of 20:35, 30 December 2024

P2RY8 is a gene that encodes a protein belonging to the family of G-protein coupled receptors (GPCRs). These receptors are involved in various physiological processes and are known for their role in signal transduction across cell membranes.

Function[edit]

The P2RY8 gene is part of the purinergic receptor family, which is activated by nucleotides such as ATP and ADP. These receptors play a crucial role in the regulation of immune response, inflammation, and cell proliferation.

Clinical Significance[edit]

Mutations or alterations in the P2RY8 gene have been associated with certain types of leukemia, particularly in cases of acute lymphoblastic leukemia (ALL). The gene is often involved in chromosomal translocations that can lead to the development of cancer.

Expression[edit]

P2RY8 is expressed in various tissues, with significant expression in the immune system, particularly in lymphocytes. Its expression pattern suggests a role in the regulation of immune cell function and development.

Research[edit]

Ongoing research is focused on understanding the precise mechanisms by which P2RY8 influences cell signaling and its potential as a therapeutic target in cancer treatment. Studies are also exploring its role in other diseases involving the immune system.

References[edit]

External Links[edit]

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-'''P2RY8''' is a gene that encodes a protein in humans. It is also known as the '''P2Y purinoceptor 8''' gene. This gene is a member of the [[G protein-coupled receptor]] family, which is a large protein family of transmembrane receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses.
+{{Infobox gene
+| name = P2RY8
+| symbol = P2RY8
+| HGNCid = 15566
+| chromosome = X
+| arm = p
+| band = 11.4
+}}
+'''P2RY8''' is a gene that encodes a protein belonging to the family of [[G-protein coupled receptors]] (GPCRs). These receptors are involved in various physiological processes and are known for their role in signal transduction across cell membranes.
 == Function ==
+The P2RY8 gene is part of the purinergic receptor family, which is activated by [[nucleotides]] such as [[ATP]] and [[ADP]]. These receptors play a crucial role in the regulation of [[immune response]], [[inflammation]], and [[cell proliferation]].
-The P2RY8 gene is involved in the regulation of [[immune system]] responses. It is particularly important in the functioning of [[B cells]], which are a type of white blood cell that produces [[antibodies]] to help fight infections. The P2RY8 gene is also involved in the migration of B cells to specific areas of the body where they are needed.
+== Clinical Significance ==
+Mutations or alterations in the P2RY8 gene have been associated with certain types of [[leukemia]], particularly in cases of [[acute lymphoblastic leukemia]] (ALL). The gene is often involved in chromosomal translocations that can lead to the development of cancer.
-== Clinical significance ==
-Mutations in the P2RY8 gene have been associated with a variety of medical conditions. For example, alterations in this gene have been linked to [[autoimmune diseases]], such as [[rheumatoid arthritis]] and [[systemic lupus erythematosus]]. Additionally, mutations in P2RY8 have been implicated in certain types of [[cancer]], including [[non-Hodgkin lymphoma]] and [[chronic lymphocytic leukemia]].
+== Expression ==
+P2RY8 is expressed in various tissues, with significant expression in the [[immune system]], particularly in [[lymphocytes]]. Its expression pattern suggests a role in the regulation of immune cell function and development.
 == Research ==
+Ongoing research is focused on understanding the precise mechanisms by which P2RY8 influences cell signaling and its potential as a therapeutic target in cancer treatment. Studies are also exploring its role in other diseases involving the immune system.
-Research into the P2RY8 gene is ongoing, with scientists seeking to better understand its role in the immune system and its potential as a target for new treatments for autoimmune diseases and cancers.
+== See Also ==
+* [[G-protein coupled receptor]]
+* [[Purinergic signaling]]
+* [[Leukemia]]
-[[File:P2RY8 gene location on human chromosome 1.png|thumb|right|300px|Location of the P2RY8 gene on human chromosome 1.]]
+== References ==
+<references/>
-== See also ==
-* [[P2Y receptor]]
-* [[G protein-coupled receptor]]
-* [[B cell]]
-* [[Autoimmune disease]]
-* [[Cancer]]
-== References ==
+== External Links ==
+* [https://www.ncbi.nlm.nih.gov/gene/ P2RY8 Gene - NCBI]
+* [https://www.genecards.org/cgi-bin/carddisp.pl?gene=P2RY8 P2RY8 Gene - GeneCards]
-{{Reflist}}
+{{Receptor-stub}}
-[[Category:Genes]]
+[[Category:Genes on human chromosome X]]
-[[Category:Human proteins]]
+[[Category:G protein-coupled receptors]]
 [[Category:Immune system]]
-[[Category:Medical genetics]]
 [[Category:Oncology]]
-[[Category:Rheumatology]]
-{{G protein-coupled receptors}}
-{{Human chromosome 1 gene stubs}}
-{{medicine-stub}}