ZNF384

ZNF384 is a gene that encodes a zinc finger protein in humans. The protein encoded by this gene is a transcription factor that can bind to many different promoter regions, indicating that it may be involved in many different cellular processes.

Function

The ZNF384 gene encodes a zinc finger protein, which is a type of protein that can bind to specific sequences of DNA. Zinc finger proteins are involved in a variety of biological processes, including cell differentiation, cell growth, apoptosis, and DNA repair. The ZNF384 protein specifically has been shown to bind to the promoter regions of several different genes, suggesting that it may play a role in regulating gene expression.

Clinical significance

Mutations in the ZNF384 gene have been associated with several types of cancer, including acute lymphoblastic leukemia (ALL) and epithelial ovarian cancer. In ALL, ZNF384 gene rearrangements have been identified in approximately 4% of patients. These rearrangements result in the production of a fusion protein that is believed to contribute to the development of the disease.

Research

Research into the ZNF384 gene and its associated protein is ongoing. Current areas of focus include understanding the specific role of the ZNF384 protein in normal cellular processes and determining how mutations in the ZNF384 gene contribute to the development of cancer.

See also

• Zinc finger
• Transcription factor
• Acute lymphoblastic leukemia
• Epithelial ovarian cancer

References

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