Dexamethasone acetate: Difference between revisions
CSV import Tags: mobile edit mobile web edit |
CSV import |
||
| Line 1: | Line 1: | ||
'''Dexamethasone | {{Short description|A synthetic glucocorticoid corticosteroid}} | ||
{{Drugbox | |||
| verifiedfields = changed | |||
| verifiedrevid = 477002123 | |||
| image = Dexamethasone_acetate.svg | |||
| image_size = 250px | |||
| image_alt = | |||
| image_caption = Chemical structure of Dexamethasone acetate | |||
}} | |||
'''Dexamethasone acetate''' is a [[synthetic]] [[glucocorticoid]] [[corticosteroid]] used in various medical conditions for its anti-inflammatory and immunosuppressant properties. It is an ester of [[dexamethasone]], a potent [[corticosteroid]] with a wide range of applications in [[medicine]]. | |||
==Pharmacology== | ==Pharmacology== | ||
Dexamethasone | Dexamethasone acetate functions by mimicking the effects of [[cortisol]], a natural hormone produced by the [[adrenal glands]]. It binds to [[glucocorticoid receptors]] in the body, leading to a decrease in the production of inflammatory mediators and suppression of the immune response. This makes it effective in treating conditions such as [[allergies]], [[asthma]], [[rheumatoid arthritis]], and certain types of [[cancer]]. | ||
==Uses== | ==Medical Uses== | ||
Dexamethasone | Dexamethasone acetate is used in the management of various conditions, including: | ||
* [[Inflammatory disorders]]: It reduces inflammation in conditions like [[arthritis]] and [[lupus]]. | |||
* [[Allergic reactions]]: It is used to treat severe allergic reactions and [[anaphylaxis]]. | |||
* [[Autoimmune diseases]]: It helps in managing diseases where the immune system attacks the body, such as [[multiple sclerosis]]. | |||
* [[Cancer]]: It is used as part of chemotherapy regimens to reduce inflammation and manage side effects. | |||
==Side Effects== | ==Side Effects== | ||
Like | Like other corticosteroids, dexamethasone acetate can cause side effects, especially with long-term use. Common side effects include: | ||
* [[Weight gain]] | |||
* [[Hypertension]] | |||
* [[Hyperglycemia]] | |||
* [[Osteoporosis]] | |||
* [[Mood changes]] | |||
==Administration== | |||
Dexamethasone acetate can be administered in various forms, including [[oral]], [[intravenous]], and [[intramuscular]] injections. The route of administration depends on the condition being treated and the desired speed of action. | |||
== | ==Mechanism of Action== | ||
Dexamethasone acetate exerts its effects by binding to the [[glucocorticoid receptor]], which then translocates to the [[cell nucleus]] and influences the expression of specific genes. This results in the suppression of pro-inflammatory cytokines and the promotion of anti-inflammatory proteins. | |||
== | ==Related pages== | ||
* [[Corticosteroid]] | |||
* [[Glucocorticoid]] | * [[Glucocorticoid]] | ||
* [[ | * [[Dexamethasone]] | ||
* [[ | * [[Adrenal gland]] | ||
[[Category: | [[Category:Glucocorticoids]] | ||
[[Category: | [[Category:Corticosteroids]] | ||
Revision as of 06:23, 16 February 2025
A synthetic glucocorticoid corticosteroid
| Dexamethasone acetate | |
|---|---|
| |
| INN | |
| Drug class | |
| Routes of administration | |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Legal status | |
| CAS Number | |
| PubChem | |
| DrugBank | |
| ChemSpider | |
| KEGG | |
Dexamethasone acetate is a synthetic glucocorticoid corticosteroid used in various medical conditions for its anti-inflammatory and immunosuppressant properties. It is an ester of dexamethasone, a potent corticosteroid with a wide range of applications in medicine.
Pharmacology
Dexamethasone acetate functions by mimicking the effects of cortisol, a natural hormone produced by the adrenal glands. It binds to glucocorticoid receptors in the body, leading to a decrease in the production of inflammatory mediators and suppression of the immune response. This makes it effective in treating conditions such as allergies, asthma, rheumatoid arthritis, and certain types of cancer.
Medical Uses
Dexamethasone acetate is used in the management of various conditions, including:
- Inflammatory disorders: It reduces inflammation in conditions like arthritis and lupus.
- Allergic reactions: It is used to treat severe allergic reactions and anaphylaxis.
- Autoimmune diseases: It helps in managing diseases where the immune system attacks the body, such as multiple sclerosis.
- Cancer: It is used as part of chemotherapy regimens to reduce inflammation and manage side effects.
Side Effects
Like other corticosteroids, dexamethasone acetate can cause side effects, especially with long-term use. Common side effects include:
Administration
Dexamethasone acetate can be administered in various forms, including oral, intravenous, and intramuscular injections. The route of administration depends on the condition being treated and the desired speed of action.
Mechanism of Action
Dexamethasone acetate exerts its effects by binding to the glucocorticoid receptor, which then translocates to the cell nucleus and influences the expression of specific genes. This results in the suppression of pro-inflammatory cytokines and the promotion of anti-inflammatory proteins.
