Trional: Difference between revisions

Revision as of 16:17, 9 February 2025

Trional

Trional is a sedative and hypnotic drug that was first introduced in the late 19th century. It is chemically known as 2,2-bis(ethylsulfonyl)propane and belongs to the class of sulfonal derivatives. Trional was widely used in the early 20th century for its calming effects and ability to induce sleep.

History

Trional was first synthesized in 1888 by the German chemist Eugen Baumann. It was developed as a derivative of sulfonal, which was already known for its sedative properties. Trional gained popularity as a sleep aid and was marketed under various brand names. It was commonly used in the treatment of insomnia and other sleep disorders.

Chemical Properties

Trional is a white crystalline powder that is soluble in alcohol and ether, but only slightly soluble in water. Its chemical formula is C₈H₁₆O₄S₂. The compound is characterized by the presence of two ethylsulfonyl groups attached to a central propane structure.

Pharmacology

Trional acts as a central nervous system depressant. It enhances the activity of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in the brain, leading to sedative and hypnotic effects. The drug was used to promote sleep and reduce anxiety, but its use declined with the development of safer and more effective medications.

Medical Use

In the past, Trional was prescribed for the treatment of insomnia and anxiety. However, due to its potential for addiction and side effects, its use has been largely discontinued. Modern benzodiazepines and other hypnotics have replaced Trional in clinical practice.

Side Effects

Common side effects of Trional included drowsiness, dizziness, and headache. In some cases, prolonged use could lead to tolerance and dependence. Overdose of Trional could result in severe respiratory depression and coma.

Related Pages

References

Baumann, E. (1888). "Ueber einige neue Derivate des Methans". Berichte der deutschen chemischen Gesellschaft, 21(2), 2743-2745.
Sneader, W. (2005). "Drug Discovery: A History". John Wiley & Sons.

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-'''Trional''' is a [[sedative]] and [[hypnotic]] drug that was historically used in the late 19th and early 20th centuries. It is a derivative of [[sulfonal]], another sedative and hypnotic drug, and was often used as a substitute for it. Trional is chemically known as [[diethylsulfondimethylmethane]].
+== Trional ==
+[[File:Trional.svg|thumb|Structural formula of Trional]]
+[[File:Trional_ball-and-stick.png|thumb|Ball-and-stick model of Trional]]
+'''Trional''' is a [[sedative]] and [[hypnotic]] drug that was first introduced in the late 19th century. It is chemically known as 2,2-bis(ethylsulfonyl)propane and belongs to the class of [[sulfonal]] derivatives. Trional was widely used in the early 20th century for its calming effects and ability to induce sleep.
 == History ==
+Trional was first synthesized in 1888 by the German chemist [[Eugen Baumann]]. It was developed as a derivative of [[sulfonal]], which was already known for its sedative properties. Trional gained popularity as a sleep aid and was marketed under various brand names. It was commonly used in the treatment of [[insomnia]] and other sleep disorders.
-Trional was first synthesized in 1888 by the German chemist [[Oscar Liebreich]]. It was introduced as a safer and more effective alternative to sulfonal, which was known to cause harmful side effects such as [[dermatitis]], [[gastritis]], and [[neuritis]]. Trional was widely used in the treatment of [[insomnia]] and [[anxiety]] disorders until the mid-20th century, when it was largely replaced by newer and safer drugs.
+== Chemical Properties ==
+Trional is a [[white]] crystalline powder that is soluble in [[alcohol]] and [[ether]], but only slightly soluble in [[water]]. Its chemical formula is C<sub>8</sub>H<sub>16</sub>O<sub>4</sub>S<sub>2</sub>. The compound is characterized by the presence of two ethylsulfonyl groups attached to a central propane structure.
 == Pharmacology ==
+Trional acts as a central nervous system [[depressant]]. It enhances the activity of the inhibitory neurotransmitter [[gamma-aminobutyric acid]] (GABA) in the brain, leading to sedative and hypnotic effects. The drug was used to promote sleep and reduce anxiety, but its use declined with the development of safer and more effective medications.
-Trional acts on the [[central nervous system]] (CNS) to produce its sedative and hypnotic effects. It is believed to work by enhancing the activity of [[gamma-aminobutyric acid]] (GABA), a neurotransmitter that inhibits the activity of the CNS. This results in a decrease in nervous tension and promotes sleep.
+== Medical Use ==
+In the past, Trional was prescribed for the treatment of insomnia and anxiety. However, due to its potential for [[addiction]] and [[side effects]], its use has been largely discontinued. Modern [[benzodiazepines]] and other [[hypnotics]] have replaced Trional in clinical practice.
 == Side Effects ==
+Common side effects of Trional included [[drowsiness]], [[dizziness]], and [[headache]]. In some cases, prolonged use could lead to [[tolerance]] and [[dependence]]. Overdose of Trional could result in severe [[respiratory depression]] and [[coma]].
-Like all drugs, Trional can cause side effects. These can include dizziness, nausea, vomiting, and in severe cases, respiratory depression and coma. Long-term use of Trional can lead to addiction and withdrawal symptoms upon cessation of use.
+== Related Pages ==
+* [[Sulfonal]]
+* [[Hypnotic]]
+* [[Sedative]]
+* [[Insomnia]]
-== Legacy ==
+== References ==
+* Baumann, E. (1888). "Ueber einige neue Derivate des Methans". Berichte der deutschen chemischen Gesellschaft, 21(2), 2743-2745.
+* Sneader, W. (2005). "Drug Discovery: A History". John Wiley & Sons.
-Despite its historical significance, Trional is rarely used today due to the development of safer and more effective drugs. However, it remains an important part of the history of pharmacology and medicine.
+{{Authority control}}
-[[Category:Drugs]]
 [[Category:Sedatives]]
 [[Category:Hypnotics]]
-[[Category:History of Medicine]]
+[[Category:Sulfonal derivatives]]
-{{pharma-stub}}