CD151: Difference between revisions
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''' | == CD151 == | ||
[[File:Fibrosarcoma_cells_CD151.jpg|thumb|right|Fibrosarcoma cells expressing CD151]] | |||
'''CD151''' is a protein that in humans is encoded by the ''CD151'' gene. It is a member of the [[tetraspanin]] family, which are cell surface proteins involved in the regulation of cell development, activation, growth, and motility. CD151 is also known as the [[Cluster of differentiation|cluster of differentiation]] 151. | |||
== Structure == | |||
CD151 is a transmembrane protein that spans the cell membrane four times, characteristic of the tetraspanin family. It has two extracellular loops, a small intracellular loop, and short cytoplasmic tails. The large extracellular loop is involved in protein-protein interactions, which are crucial for its function in cell adhesion and signaling. | |||
== Function == | == Function == | ||
CD151 plays a significant role in cell adhesion, migration, and signaling. It is known to associate with [[integrins]], particularly [[integrin alpha3]] and [[integrin alpha6]], forming complexes that are important for the stabilization of cell-cell and cell-matrix interactions. These interactions are critical in processes such as [[angiogenesis]], [[tumor metastasis]], and [[wound healing]]. | |||
== Clinical | == Clinical Significance == | ||
CD151 has been implicated in various pathological conditions, including cancer. It is often overexpressed in [[carcinomas]] and is associated with poor prognosis in several types of cancer, such as [[breast cancer]], [[prostate cancer]], and [[melanoma]]. CD151 promotes cancer cell migration and invasion, contributing to [[metastasis]]. | |||
In addition to its role in cancer, CD151 is involved in [[kidney disease]]. Mutations in the ''CD151'' gene can lead to [[nephropathy]] and [[hearing loss]], as seen in some genetic syndromes. | |||
== Research == | == Research == | ||
Research | Research on CD151 is ongoing to better understand its role in disease and its potential as a therapeutic target. Inhibiting CD151 function has been proposed as a strategy to prevent cancer metastasis. Studies are also exploring its role in [[angiogenesis]] and its potential impact on [[cardiovascular disease]]. | ||
== | == Related pages == | ||
* [[Tetraspanin]] | * [[Tetraspanin]] | ||
* [[ | * [[Integrin]] | ||
* [[ | * [[Cell adhesion]] | ||
* [[ | * [[Cancer metastasis]] | ||
[[Category:Cell surface proteins]] | |||
[[Category:Clusters of differentiation]] | |||
[[Category:Cell | [[Category:Human proteins]] | ||
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[[Category: | |||
Latest revision as of 11:48, 15 February 2025
CD151[edit]
CD151 is a protein that in humans is encoded by the CD151 gene. It is a member of the tetraspanin family, which are cell surface proteins involved in the regulation of cell development, activation, growth, and motility. CD151 is also known as the cluster of differentiation 151.
Structure[edit]
CD151 is a transmembrane protein that spans the cell membrane four times, characteristic of the tetraspanin family. It has two extracellular loops, a small intracellular loop, and short cytoplasmic tails. The large extracellular loop is involved in protein-protein interactions, which are crucial for its function in cell adhesion and signaling.
Function[edit]
CD151 plays a significant role in cell adhesion, migration, and signaling. It is known to associate with integrins, particularly integrin alpha3 and integrin alpha6, forming complexes that are important for the stabilization of cell-cell and cell-matrix interactions. These interactions are critical in processes such as angiogenesis, tumor metastasis, and wound healing.
Clinical Significance[edit]
CD151 has been implicated in various pathological conditions, including cancer. It is often overexpressed in carcinomas and is associated with poor prognosis in several types of cancer, such as breast cancer, prostate cancer, and melanoma. CD151 promotes cancer cell migration and invasion, contributing to metastasis.
In addition to its role in cancer, CD151 is involved in kidney disease. Mutations in the CD151 gene can lead to nephropathy and hearing loss, as seen in some genetic syndromes.
Research[edit]
Research on CD151 is ongoing to better understand its role in disease and its potential as a therapeutic target. Inhibiting CD151 function has been proposed as a strategy to prevent cancer metastasis. Studies are also exploring its role in angiogenesis and its potential impact on cardiovascular disease.
