Cholecystokinin A receptor: Difference between revisions
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{{DISPLAYTITLE:Cholecystokinin A Receptor}} | |||
== | ==Cholecystokinin A Receptor== | ||
The '''cholecystokinin A receptor''' (CCKAR), also known as the '''CCK1 receptor''', is a [[G protein-coupled receptor]] that binds the [[peptide hormone]] [[cholecystokinin]] (CCK). This receptor is primarily found in the [[gastrointestinal tract]] and the [[central nervous system]], where it plays a crucial role in digestion and appetite regulation. | |||
[[File:PDB_1d6g_EBI.jpg|thumb|right|300px|Structure of the cholecystokinin A receptor.]] | |||
== Structure == | ==Structure== | ||
The CCKA receptor is a member of the [[G protein-coupled receptor]] (GPCR) family, characterized by its seven transmembrane alpha-helices. The receptor's structure allows it to interact with G proteins, which are intracellular proteins that transmit signals from the receptor to various signaling pathways within the cell. | |||
The | ==Function== | ||
The primary function of the CCKA receptor is to mediate the effects of cholecystokinin in the body. When CCK binds to the CCKA receptor, it triggers a cascade of intracellular events that lead to the secretion of [[digestive enzymes]] from the [[pancreas]] and the release of [[bile]] from the [[gallbladder]]. This process is essential for the digestion of fats and proteins. | |||
In addition to its role in digestion, the CCKA receptor is involved in regulating [[satiety]] and [[appetite]]. Activation of the receptor in the brain can lead to a feeling of fullness, thereby reducing food intake. | |||
==Distribution== | |||
The CCKA receptor is predominantly expressed in the [[gastrointestinal tract]], particularly in the [[pancreas]], [[gallbladder]], and [[small intestine]]. It is also found in the [[central nervous system]], including areas of the [[brain]] involved in appetite control. | |||
== | ==Clinical Significance== | ||
Alterations in CCKA receptor function or expression can have significant clinical implications. Dysregulation of this receptor has been associated with [[obesity]], [[pancreatitis]], and [[gallstone]] formation. Understanding the role of the CCKA receptor in these conditions can help in developing targeted therapies. | |||
* [[Cholecystokinin | ==Related pages== | ||
* [[Cholecystokinin]] | |||
* [[G protein-coupled receptor]] | * [[G protein-coupled receptor]] | ||
* [[ | * [[Digestive system]] | ||
* [[Appetite regulation]] | |||
[[Category:Receptors]] | |||
[[Category:G protein-coupled receptors]] | [[Category:G protein-coupled receptors]] | ||
[[Category:Digestive system]] | [[Category:Digestive system]] | ||
Latest revision as of 05:56, 16 February 2025
Cholecystokinin A Receptor[edit]
The cholecystokinin A receptor (CCKAR), also known as the CCK1 receptor, is a G protein-coupled receptor that binds the peptide hormone cholecystokinin (CCK). This receptor is primarily found in the gastrointestinal tract and the central nervous system, where it plays a crucial role in digestion and appetite regulation.
Structure[edit]
The CCKA receptor is a member of the G protein-coupled receptor (GPCR) family, characterized by its seven transmembrane alpha-helices. The receptor's structure allows it to interact with G proteins, which are intracellular proteins that transmit signals from the receptor to various signaling pathways within the cell.
Function[edit]
The primary function of the CCKA receptor is to mediate the effects of cholecystokinin in the body. When CCK binds to the CCKA receptor, it triggers a cascade of intracellular events that lead to the secretion of digestive enzymes from the pancreas and the release of bile from the gallbladder. This process is essential for the digestion of fats and proteins.
In addition to its role in digestion, the CCKA receptor is involved in regulating satiety and appetite. Activation of the receptor in the brain can lead to a feeling of fullness, thereby reducing food intake.
Distribution[edit]
The CCKA receptor is predominantly expressed in the gastrointestinal tract, particularly in the pancreas, gallbladder, and small intestine. It is also found in the central nervous system, including areas of the brain involved in appetite control.
Clinical Significance[edit]
Alterations in CCKA receptor function or expression can have significant clinical implications. Dysregulation of this receptor has been associated with obesity, pancreatitis, and gallstone formation. Understanding the role of the CCKA receptor in these conditions can help in developing targeted therapies.
