IFNA16: Difference between revisions

Latest revision as of 22:42, 15 December 2024

IFNA16

IFNA16 is a gene that encodes a member of the interferon family, specifically the type I interferons. Interferons are proteins that are part of the immune response, playing a crucial role in the defense against viral infections and in the regulation of the immune system.

Structure[edit]

The IFNA16 gene is located on the short arm of chromosome 9 in humans. It is part of a cluster of interferon alpha genes, which are known for their antiviral activities. The gene encodes a protein that is secreted by cells in response to viral infections and other stimuli.

Function[edit]

The protein product of the IFNA16 gene is an interferon alpha subtype. Interferon alphas are cytokines that have antiviral, antiproliferative, and immunomodulatory effects. They bind to specific receptors on the surface of cells, initiating a signaling cascade that leads to the expression of numerous interferon-stimulated genes (ISGs). These ISGs help to establish an antiviral state in the cell, inhibiting viral replication and spread.

Clinical Significance[edit]

Interferons, including those encoded by IFNA16, are used therapeutically in the treatment of various diseases. For example, recombinant interferon alpha is used in the treatment of chronic hepatitis C, hepatitis B, and certain types of cancer, such as melanoma and leukemia.

The expression of IFNA16 and other interferon genes can be dysregulated in certain autoimmune diseases, such as systemic lupus erythematosus (SLE), where an overactive interferon response contributes to disease pathology.

Research[edit]

Ongoing research is focused on understanding the specific roles of different interferon alpha subtypes, including IFNA16, in immune responses and their potential therapeutic applications. Studies are also investigating the genetic regulation of IFNA16 expression and its impact on disease susceptibility and progression.

Also see[edit]

Template:Interferon family

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-'''IFNA16''' is a gene that in humans encodes the alpha 16 subunit of interferon, proteins and glycoproteins which are produced by the cells of the immune system in response to challenges by foreign agents such as viruses, parasites and tumor cells.
+IFNA16
-== Function ==
+'''IFNA16''' is a gene that encodes a member of the [[interferon]] family, specifically the type I interferons. Interferons are proteins that are part of the immune response, playing a crucial role in the defense against viral infections and in the regulation of the immune system.
-Interferons are proteins that are produced and released by host cells in response to the presence of pathogens such as viruses, bacteria, parasites or tumor cells. They allow communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors.
-IFNA16 belongs to the alpha/beta interferon family. Two variants of the alpha-16 subunit have been identified.
+==Structure==
+The IFNA16 gene is located on the short arm of chromosome 9 in humans. It is part of a cluster of interferon alpha genes, which are known for their antiviral activities. The gene encodes a protein that is secreted by cells in response to viral infections and other stimuli.
-== Clinical significance ==
+==Function==
-Interferons have been recognized for their anti-viral, anti-proliferative, and immune-modulating properties. They are used therapeutically in the treatment of a number of diseases, including certain cancers and viral infections.
+The protein product of the IFNA16 gene is an [[interferon alpha]] subtype. Interferon alphas are cytokines that have antiviral, antiproliferative, and immunomodulatory effects. They bind to specific receptors on the surface of cells, initiating a signaling cascade that leads to the expression of numerous interferon-stimulated genes (ISGs). These ISGs help to establish an antiviral state in the cell, inhibiting viral replication and spread.
-== References ==
+==Clinical Significance==
-<references />
+Interferons, including those encoded by IFNA16, are used therapeutically in the treatment of various diseases. For example, recombinant interferon alpha is used in the treatment of chronic [[hepatitis C]], [[hepatitis B]], and certain types of [[cancer]], such as [[melanoma]] and [[leukemia]].
-== External links ==
+The expression of IFNA16 and other interferon genes can be dysregulated in certain autoimmune diseases, such as [[systemic lupus erythematosus]] (SLE), where an overactive interferon response contributes to disease pathology.
-* [https://www.ncbi.nlm.nih.gov/gene/3452 NCBI Entrez Gene]
-[[Category:Genes]]
+==Research==
+Ongoing research is focused on understanding the specific roles of different interferon alpha subtypes, including IFNA16, in immune responses and their potential therapeutic applications. Studies are also investigating the genetic regulation of IFNA16 expression and its impact on disease susceptibility and progression.
+==Also see==
+* [[Interferon alpha]]
+* [[Interferon]]
+* [[Cytokine]]
+* [[Immune system]]
+* [[Viral infection]]
+{{Interferon family}}
+{{Immune system}}
+[[Category:Genes on human chromosome 9]]
 [[Category:Interferons]]
-[[Category:Proteins]]
 [[Category:Immune system]]
-{{stub}}