CCL3

CCL3, also known as Macrophage Inflammatory Protein-1α (MIP-1α), is a cytokine involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes.

Function

CCL3 has been found to interact with chemokine receptors such as CCR1, CCR4 and CCR5. It is a major HIV-suppressive factor produced by CD8+ T-cells. The protein is an important factor in the inflammatory response of blood monocytes, and plays a key role in the immune response to bacterial pathogens.

Clinical significance

CCL3 may be implicated in the pathology of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It may be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.

See also

• Chemokine
• Chemokine receptor
• Cytokine
• CCR5
• CCR1
• CCR4

References

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External links

• CCL3 at the US National Library of Medicine Medical Subject Headings (MeSH)

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