Pregnane

Pregnane is a parent hydrocarbon for two series of steroids formed by the addition of side chains to carbon atoms 10 and 13 and by oxidation at other atoms.

Chemical Structure

Pregnane is a 21-carbon steroid. The name pregnane is derived from the Latin word 'pregnans', which means 'pregnant'. The pregnane steroid series comprise a group of substances including progesterone, corticosteroids, glucocorticoids, mineralocorticoids, progestins, and neurosteroids.

Biological Role

Pregnane steroids are key components of biological systems. They play crucial roles in various biological functions such as metabolism, immune response, and neural activity. They are also involved in the regulation of inflammation, blood pressure, and blood sugar levels.

Synthesis

Pregnane steroids are synthesized from cholesterol in the adrenal glands, ovaries, testes, and placenta. The synthesis involves several enzymatic steps, including the conversion of cholesterol to pregnenolone, which is then converted to progesterone.

Clinical Significance

Pregnane steroids have significant clinical applications. They are used in the treatment of a variety of conditions, including autoimmune diseases, inflammatory diseases, endocrine disorders, and neurological disorders. They are also used in contraceptive formulations.

See Also

• Steroid
• Progesterone
• Corticosteroids
• Glucocorticoids
• Mineralocorticoids
• Progestins
• Neurosteroids

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