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{{SI}} | |||
{{Infobox medical condition | |||
| name = Dwarfism | |||
| image = [[File:Ethan_Crough,_male_dwarf.jpg|250px]] | |||
| caption = Ethan Crough, a male with dwarfism | |||
| field = [[Medical genetics]] | |||
| synonyms = Short stature | |||
| symptoms = Short stature, [[disproportionate body parts]] | |||
| complications = [[Arthritis]], [[spinal stenosis]], [[sleep apnea]] | |||
| onset = Congenital | |||
| duration = Lifelong | |||
| causes = [[Genetic mutation]] | |||
| risks = [[Family history]] | |||
| diagnosis = [[Physical examination]], [[genetic testing]] | |||
| differential = [[Growth hormone deficiency]], [[Turner syndrome]] | |||
| prevention = None | |||
| treatment = [[Hormone therapy]], [[surgery]] | |||
| medication = [[Growth hormone]] | |||
| prognosis = Generally good with treatment | |||
| frequency = 1 in 15,000 to 40,000 people | |||
}} | |||
'''Dwarfism''' is a condition characterized by an organism's exceptionally small size. In humans, it is sometimes defined as an adult height of less than 147 centimeters (4 ft 10 in), regardless of sex. The average adult height among people with dwarfism is 122 centimeters (4 ft 0 in), although some individuals may be slightly taller. Dwarfism can be classified into two main categories: disproportionate and proportionate. Intelligence is usually normal, and most individuals with dwarfism have a nearly normal life expectancy. People with dwarfism can usually bear children, although there are additional risks to both mother and child, depending on the underlying condition. | '''Dwarfism''' is a condition characterized by an organism's exceptionally small size. In humans, it is sometimes defined as an adult height of less than 147 centimeters (4 ft 10 in), regardless of sex. The average adult height among people with dwarfism is 122 centimeters (4 ft 0 in), although some individuals may be slightly taller. Dwarfism can be classified into two main categories: disproportionate and proportionate. Intelligence is usually normal, and most individuals with dwarfism have a nearly normal life expectancy. People with dwarfism can usually bear children, although there are additional risks to both mother and child, depending on the underlying condition. | ||
[[File:Ethan Crough, male dwarf.jpg|left|thumb|Male dwarf]] | |||
[[File:Ethan Crough, male dwarf.jpg|thumb|Male dwarf]] | |||
== Types of Dwarfism == | == Types of Dwarfism == | ||
There are two primary types of dwarfism: disproportionate and proportionate. | There are two primary types of dwarfism: disproportionate and proportionate. | ||
=== Disproportionate Dwarfism === | === Disproportionate Dwarfism === | ||
Disproportionate dwarfism is characterized by either short limbs or a short torso. The most common cause of disproportionate dwarfism is achondroplasia, a genetic disorder that affects bone growth and results in shortened limbs and a relatively normal-sized torso. Other examples of disproportionate dwarfism include: | Disproportionate dwarfism is characterized by either short limbs or a short torso. The most common cause of disproportionate dwarfism is achondroplasia, a genetic disorder that affects bone growth and results in shortened limbs and a relatively normal-sized torso. Other examples of disproportionate dwarfism include: | ||
* '''Diastrophic dysplasia''': A rare genetic disorder characterized by short limbs and joint deformities. | * '''Diastrophic dysplasia''': A rare genetic disorder characterized by short limbs and joint deformities. | ||
* '''Spondyloepiphyseal dysplasia congenita (SEDc)''': A genetic disorder that affects the growth of vertebrae and long bones, resulting in short stature and skeletal abnormalities. | * '''Spondyloepiphyseal dysplasia congenita (SEDc)''': A genetic disorder that affects the growth of vertebrae and long bones, resulting in short stature and skeletal abnormalities. | ||
=== Proportionate Dwarfism === | === Proportionate Dwarfism === | ||
[[File:Lavinia_Warren_-_Brady-Handy.jpg|thumb|Actress Lavinia_Warren]] | [[File:Lavinia_Warren_-_Brady-Handy.jpg|left|thumb|Actress Lavinia_Warren]] | ||
In cases of proportionate dwarfism, both the limbs and torso are unusually small. Causes of proportionate dwarfism include: | In cases of proportionate dwarfism, both the limbs and torso are unusually small. Causes of proportionate dwarfism include: | ||
* '''Growth hormone deficiency''': A condition in which the pituitary gland does not produce enough growth hormone, leading to slow and inadequate growth. | * '''Growth hormone deficiency''': A condition in which the pituitary gland does not produce enough growth hormone, leading to slow and inadequate growth. | ||
* '''[[Turner syndrome]]''': A genetic disorder affecting females that results from the partial or complete absence of one of the X chromosomes, causing short stature and other physical abnormalities. | * '''[[Turner syndrome]]''': A genetic disorder affecting females that results from the partial or complete absence of one of the X chromosomes, causing short stature and other physical abnormalities. | ||
* '''[[Prader-Willi syndrome]]''': A complex genetic disorder that leads to poor muscle tone, short stature, and an insatiable appetite, among other symptoms. | * '''[[Prader-Willi syndrome]]''': A complex genetic disorder that leads to poor muscle tone, short stature, and an insatiable appetite, among other symptoms. | ||
== Causes of Dwarfism == | == Causes of Dwarfism == | ||
Dwarfism can be caused by a variety of factors, including genetic mutations, hormonal imbalances, and metabolic disorders. Some of the most common causes include: | Dwarfism can be caused by a variety of factors, including genetic mutations, hormonal imbalances, and metabolic disorders. Some of the most common causes include: | ||
* '''[[Achondroplasia]]''': The most common form of disproportionate dwarfism, achondroplasia is a genetic disorder caused by a mutation in the FGFR3 gene. | * '''[[Achondroplasia]]''': The most common form of disproportionate dwarfism, achondroplasia is a genetic disorder caused by a mutation in the FGFR3 gene. | ||
* '''[[Growth hormone deficiency]]''': A lack of growth hormone production by the pituitary gland can result in proportionate dwarfism. | * '''[[Growth hormone deficiency]]''': A lack of growth hormone production by the pituitary gland can result in proportionate dwarfism. | ||
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* | * | ||
== Diagnosis and Treatment == | == Diagnosis and Treatment == | ||
Diagnosis of dwarfism typically involves a combination of physical examination, medical history, and imaging studies, such as X-rays or MRI scans. Genetic testing may also be used to identify specific genetic disorders. | Diagnosis of dwarfism typically involves a combination of physical examination, medical history, and imaging studies, such as X-rays or MRI scans. Genetic testing may also be used to identify specific genetic disorders. | ||
Treatment for dwarfism depends on the underlying cause. In cases of growth hormone deficiency, growth hormone replacement therapy may be prescribed to promote growth. Surgical interventions, such as limb-lengthening procedures, may be considered in some cases of disproportionate dwarfism. Supportive therapies, such as physical and occupational therapy, can help individuals with dwarfism improve mobility, strength, and independence. | Treatment for dwarfism depends on the underlying cause. In cases of growth hormone deficiency, growth hormone replacement therapy may be prescribed to promote growth. Surgical interventions, such as limb-lengthening procedures, may be considered in some cases of disproportionate dwarfism. Supportive therapies, such as physical and occupational therapy, can help individuals with dwarfism improve mobility, strength, and independence. | ||
== Social Considerations and Life Expectancy == | == Social Considerations and Life Expectancy == | ||
Individuals with dwarfism often face social challenges due to their unique stature. They may encounter discrimination, prejudice, and misconceptions about their abilities and intelligence. However, people with dwarfism can lead fulfilling lives and achieve success in various fields. | Individuals with dwarfism often face social challenges due to their unique stature. They may encounter discrimination, prejudice, and misconceptions about their abilities and intelligence. However, people with dwarfism can lead fulfilling lives and achieve success in various fields. | ||
Life expectancy for individuals with dwarfism is usually near normal, although certain conditions may be associated with health complications that can affect overall lifespan. Regular medical care, monitoring, and proactive management of potential health issues are essential for maintaining a healthy life. | Life expectancy for individuals with dwarfism is usually near normal, although certain conditions may be associated with health complications that can affect overall lifespan. Regular medical care, monitoring, and proactive management of potential health issues are essential for maintaining a healthy life. | ||
== Reproduction and Pregnancy in Individuals with Dwarfism == | == Reproduction and Pregnancy in Individuals with Dwarfism == | ||
People with dwarfism can usually bear children, although there may be additional risks to both mother and child, depending on the underlying condition. For example, women with achondroplasia may face an increased risk of cesarean delivery due to a narrowed birth canal. Additionally, there is a risk of passing on the genetic mutation responsible for dwarfism to the child. | People with dwarfism can usually bear children, although there may be additional risks to both mother and child, depending on the underlying condition. For example, women with achondroplasia may face an increased risk of cesarean delivery due to a narrowed birth canal. Additionally, there is a risk of passing on the genetic mutation responsible for dwarfism to the child. | ||
Couples in which one or both partners have dwarfism should consult with a genetic counselor and healthcare professionals to assess potential risks and make informed decisions about family planning. | Couples in which one or both partners have dwarfism should consult with a genetic counselor and healthcare professionals to assess potential risks and make informed decisions about family planning. | ||
== Support and Resources == | == Support and Resources == | ||
Organizations and support groups dedicated to dwarfism can provide valuable resources, information, and connections for individuals and families affected by the condition. These groups aim to foster understanding, promote acceptance, and advocate for the rights and well-being of individuals with dwarfism. Some well-known organizations and support groups include: | Organizations and support groups dedicated to dwarfism can provide valuable resources, information, and connections for individuals and families affected by the condition. These groups aim to foster understanding, promote acceptance, and advocate for the rights and well-being of individuals with dwarfism. Some well-known organizations and support groups include: | ||
* '''Little People of America (LPA)''': A non-profit organization that provides support, resources, and advocacy for individuals with dwarfism and their families. | * '''Little People of America (LPA)''': A non-profit organization that provides support, resources, and advocacy for individuals with dwarfism and their families. | ||
* '''Dwarf Athletic Association of America (DAAA)''': A group dedicated to providing athletic opportunities and promoting sportsmanship among individuals with dwarfism. | * '''Dwarf Athletic Association of America (DAAA)''': A group dedicated to providing athletic opportunities and promoting sportsmanship among individuals with dwarfism. | ||
Latest revision as of 19:40, 5 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD's medical weight loss NYC, sleep center NYC
Philadelphia medical weight loss and Philadelphia sleep clinics
| Dwarfism | |
|---|---|
| |
| Synonyms | Short stature |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Short stature, disproportionate body parts |
| Complications | Arthritis, spinal stenosis, sleep apnea |
| Onset | Congenital |
| Duration | Lifelong |
| Types | N/A |
| Causes | Genetic mutation |
| Risks | Family history |
| Diagnosis | Physical examination, genetic testing |
| Differential diagnosis | Growth hormone deficiency, Turner syndrome |
| Prevention | None |
| Treatment | Hormone therapy, surgery |
| Medication | Growth hormone |
| Prognosis | Generally good with treatment |
| Frequency | 1 in 15,000 to 40,000 people |
| Deaths | N/A |
Dwarfism is a condition characterized by an organism's exceptionally small size. In humans, it is sometimes defined as an adult height of less than 147 centimeters (4 ft 10 in), regardless of sex. The average adult height among people with dwarfism is 122 centimeters (4 ft 0 in), although some individuals may be slightly taller. Dwarfism can be classified into two main categories: disproportionate and proportionate. Intelligence is usually normal, and most individuals with dwarfism have a nearly normal life expectancy. People with dwarfism can usually bear children, although there are additional risks to both mother and child, depending on the underlying condition.
Types of Dwarfism[edit]
There are two primary types of dwarfism: disproportionate and proportionate.
Disproportionate Dwarfism[edit]
Disproportionate dwarfism is characterized by either short limbs or a short torso. The most common cause of disproportionate dwarfism is achondroplasia, a genetic disorder that affects bone growth and results in shortened limbs and a relatively normal-sized torso. Other examples of disproportionate dwarfism include:
- Diastrophic dysplasia: A rare genetic disorder characterized by short limbs and joint deformities.
- Spondyloepiphyseal dysplasia congenita (SEDc): A genetic disorder that affects the growth of vertebrae and long bones, resulting in short stature and skeletal abnormalities.
Proportionate Dwarfism[edit]
In cases of proportionate dwarfism, both the limbs and torso are unusually small. Causes of proportionate dwarfism include:
- Growth hormone deficiency: A condition in which the pituitary gland does not produce enough growth hormone, leading to slow and inadequate growth.
- Turner syndrome: A genetic disorder affecting females that results from the partial or complete absence of one of the X chromosomes, causing short stature and other physical abnormalities.
- Prader-Willi syndrome: A complex genetic disorder that leads to poor muscle tone, short stature, and an insatiable appetite, among other symptoms.
Causes of Dwarfism[edit]
Dwarfism can be caused by a variety of factors, including genetic mutations, hormonal imbalances, and metabolic disorders. Some of the most common causes include:
- Achondroplasia: The most common form of disproportionate dwarfism, achondroplasia is a genetic disorder caused by a mutation in the FGFR3 gene.
- Growth hormone deficiency: A lack of growth hormone production by the pituitary gland can result in proportionate dwarfism.
- Genetic syndromes: Various genetic syndromes, such as Turner syndrome and Prader-Willi syndrome, can cause proportionate dwarfism.
Diagnosis and Treatment[edit]
Diagnosis of dwarfism typically involves a combination of physical examination, medical history, and imaging studies, such as X-rays or MRI scans. Genetic testing may also be used to identify specific genetic disorders. Treatment for dwarfism depends on the underlying cause. In cases of growth hormone deficiency, growth hormone replacement therapy may be prescribed to promote growth. Surgical interventions, such as limb-lengthening procedures, may be considered in some cases of disproportionate dwarfism. Supportive therapies, such as physical and occupational therapy, can help individuals with dwarfism improve mobility, strength, and independence.
Social Considerations and Life Expectancy[edit]
Individuals with dwarfism often face social challenges due to their unique stature. They may encounter discrimination, prejudice, and misconceptions about their abilities and intelligence. However, people with dwarfism can lead fulfilling lives and achieve success in various fields. Life expectancy for individuals with dwarfism is usually near normal, although certain conditions may be associated with health complications that can affect overall lifespan. Regular medical care, monitoring, and proactive management of potential health issues are essential for maintaining a healthy life.
Reproduction and Pregnancy in Individuals with Dwarfism[edit]
People with dwarfism can usually bear children, although there may be additional risks to both mother and child, depending on the underlying condition. For example, women with achondroplasia may face an increased risk of cesarean delivery due to a narrowed birth canal. Additionally, there is a risk of passing on the genetic mutation responsible for dwarfism to the child. Couples in which one or both partners have dwarfism should consult with a genetic counselor and healthcare professionals to assess potential risks and make informed decisions about family planning.
Support and Resources[edit]
Organizations and support groups dedicated to dwarfism can provide valuable resources, information, and connections for individuals and families affected by the condition. These groups aim to foster understanding, promote acceptance, and advocate for the rights and well-being of individuals with dwarfism. Some well-known organizations and support groups include:
- Little People of America (LPA): A non-profit organization that provides support, resources, and advocacy for individuals with dwarfism and their families.
- Dwarf Athletic Association of America (DAAA): A group dedicated to providing athletic opportunities and promoting sportsmanship among individuals with dwarfism.
- Restricted Growth Association (RGA): A UK-based charity that provides support and resources for individuals with dwarfism and their families.
