Neurolathyrism: Difference between revisions
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{{SI}} {{Infobox medical condition | |||
| name = Neurolathyrism | |||
| image = [[File:L-Glutaminsäure_-_L-Glutamic_acid.svg|200px]] | |||
| caption = Chemical structure of [[glutamic acid]], a component of the neurotoxic compound [[ODAP]] | |||
| field = [[Neurology]] | |||
| symptoms = [[Spasticity]], [[paraplegia]], [[muscle weakness]] | |||
| complications = [[Permanent disability]] | |||
| onset = Gradual, after prolonged consumption of [[Lathyrus sativus]] | |||
| duration = Chronic | |||
| causes = Consumption of [[Lathyrus sativus]] (grass pea) containing [[ODAP]] | |||
| risks = [[Malnutrition]], [[drought]], [[famine]] | |||
| diagnosis = Clinical evaluation, dietary history | |||
| differential = [[Tropical spastic paraparesis]], [[multiple sclerosis]] | |||
| prevention = Diversified diet, avoiding exclusive consumption of [[Lathyrus sativus]] | |||
| treatment = Supportive care, physical therapy | |||
| prognosis = Variable, often leads to permanent disability | |||
| frequency = Rare, endemic in certain regions of [[South Asia]] and [[Sub-Saharan Africa]] | |||
}} | |||
[[File:Beta-oxalylamino-L-alanine.svg|Beta-oxalylamino-L-alanine structure|thumb|left]] | |||
'''Neurolathyrism''' is a neurological disease of humans and domestic animals, caused by eating certain kinds of [[lathyrus]] peas (chickling peas) in the genus ''Lathyrus''. This disease is mainly associated with consumption of ''Lathyrus sativus'' (also known as grass pea, chickling vetch, Indian pea, white pea, and dhal) during times of famine. This disease was first described by the British neurologist, [[Lord Brain]] in 1964. | '''Neurolathyrism''' is a neurological disease of humans and domestic animals, caused by eating certain kinds of [[lathyrus]] peas (chickling peas) in the genus ''Lathyrus''. This disease is mainly associated with consumption of ''Lathyrus sativus'' (also known as grass pea, chickling vetch, Indian pea, white pea, and dhal) during times of famine. This disease was first described by the British neurologist, [[Lord Brain]] in 1964. | ||
==Symptoms== | ==Symptoms== | ||
The symptoms of neurolathyrism are characterized by gradual onset of a spastic paraparesis, which primarily affects the lower limbs. The disease is characterized by sudden onset of severe muscle weakness and paralysis from the waist down. Other symptoms may include muscle spasms, cramps, and stiffness. The disease is often associated with periods of malnutrition and is often seen in areas where the diet is poor and the main source of nutrition is the lathyrus pea. | The symptoms of neurolathyrism are characterized by gradual onset of a spastic paraparesis, which primarily affects the lower limbs. The disease is characterized by sudden onset of severe muscle weakness and paralysis from the waist down. Other symptoms may include muscle spasms, cramps, and stiffness. The disease is often associated with periods of malnutrition and is often seen in areas where the diet is poor and the main source of nutrition is the lathyrus pea. | ||
==Causes== | ==Causes== | ||
Neurolathyrism is caused by the consumption of the lathyrus pea, specifically the species ''Lathyrus sativus''. This pea contains a neurotoxin known as [[ODAP]] ( | Neurolathyrism is caused by the consumption of the lathyrus pea, specifically the species ''Lathyrus sativus''. This pea contains a neurotoxin known as [[ODAP]] (β-N-oxalyl-L-α,β-diaminopropionic acid), which is believed to cause the neurological symptoms seen in this disease. The toxin is not destroyed by cooking or boiling, and so the disease can be contracted by consuming cooked peas. | ||
==Treatment== | ==Treatment== | ||
There is currently no cure for neurolathyrism, and treatment is primarily supportive. This may include physical therapy to help manage symptoms, and nutritional support to ensure a balanced diet. Avoidance of lathyrus peas is the only known way to prevent the disease. | There is currently no cure for neurolathyrism, and treatment is primarily supportive. This may include physical therapy to help manage symptoms, and nutritional support to ensure a balanced diet. Avoidance of lathyrus peas is the only known way to prevent the disease. | ||
==Epidemiology== | ==Epidemiology== | ||
Neurolathyrism is most commonly seen in areas where lathyrus peas are a staple food, particularly during times of famine. This includes parts of Africa, Asia, and the Mediterranean. The disease is more common in men than in women, and typically affects adults between the ages of 20 and 40. | Neurolathyrism is most commonly seen in areas where lathyrus peas are a staple food, particularly during times of famine. This includes parts of Africa, Asia, and the Mediterranean. The disease is more common in men than in women, and typically affects adults between the ages of 20 and 40. | ||
==See also== | ==See also== | ||
* [[Lathyrus]] | * [[Lathyrus]] | ||
* [[Neurotoxin]] | * [[Neurotoxin]] | ||
* [[Lord Brain]] | * [[Lord Brain]] | ||
==References== | ==References== | ||
<references /> | <references /> | ||
{{stub}} | {{stub}} | ||
[[Category:Neurological disorders]] | [[Category:Neurological disorders]] | ||
[[Category:Toxic effects of substances chiefly nonmedicinal as to source]] | [[Category:Toxic effects of substances chiefly nonmedicinal as to source]] | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
Latest revision as of 05:06, 6 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD's medical weight loss NYC, sleep center NYC
Philadelphia medical weight loss and Philadelphia sleep clinics
| Neurolathyrism | |
|---|---|
| |
| Synonyms | N/A |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Spasticity, paraplegia, muscle weakness |
| Complications | Permanent disability |
| Onset | Gradual, after prolonged consumption of Lathyrus sativus |
| Duration | Chronic |
| Types | N/A |
| Causes | Consumption of Lathyrus sativus (grass pea) containing ODAP |
| Risks | Malnutrition, drought, famine |
| Diagnosis | Clinical evaluation, dietary history |
| Differential diagnosis | Tropical spastic paraparesis, multiple sclerosis |
| Prevention | Diversified diet, avoiding exclusive consumption of Lathyrus sativus |
| Treatment | Supportive care, physical therapy |
| Medication | N/A |
| Prognosis | Variable, often leads to permanent disability |
| Frequency | Rare, endemic in certain regions of South Asia and Sub-Saharan Africa |
| Deaths | N/A |
Neurolathyrism is a neurological disease of humans and domestic animals, caused by eating certain kinds of lathyrus peas (chickling peas) in the genus Lathyrus. This disease is mainly associated with consumption of Lathyrus sativus (also known as grass pea, chickling vetch, Indian pea, white pea, and dhal) during times of famine. This disease was first described by the British neurologist, Lord Brain in 1964.
Symptoms[edit]
The symptoms of neurolathyrism are characterized by gradual onset of a spastic paraparesis, which primarily affects the lower limbs. The disease is characterized by sudden onset of severe muscle weakness and paralysis from the waist down. Other symptoms may include muscle spasms, cramps, and stiffness. The disease is often associated with periods of malnutrition and is often seen in areas where the diet is poor and the main source of nutrition is the lathyrus pea.
Causes[edit]
Neurolathyrism is caused by the consumption of the lathyrus pea, specifically the species Lathyrus sativus. This pea contains a neurotoxin known as ODAP (β-N-oxalyl-L-α,β-diaminopropionic acid), which is believed to cause the neurological symptoms seen in this disease. The toxin is not destroyed by cooking or boiling, and so the disease can be contracted by consuming cooked peas.
Treatment[edit]
There is currently no cure for neurolathyrism, and treatment is primarily supportive. This may include physical therapy to help manage symptoms, and nutritional support to ensure a balanced diet. Avoidance of lathyrus peas is the only known way to prevent the disease.
Epidemiology[edit]
Neurolathyrism is most commonly seen in areas where lathyrus peas are a staple food, particularly during times of famine. This includes parts of Africa, Asia, and the Mediterranean. The disease is more common in men than in women, and typically affects adults between the ages of 20 and 40.
See also[edit]
References[edit]
<references />
