MTA1

MTA1 or Metastasis Associated 1 is a protein that in humans is encoded by the MTA1 gene. It is a part of the nuclear receptor co-repressor complex and plays a significant role in gene expression and cellular differentiation, proliferation, and apoptosis.

Function

MTA1 is a component of the NuRD, a multisubunit complex which couples histone deacetylase activity and nucleosome remodeling activity. The protein encoded by this gene is thought to play a role in the regulation of transcription and is known to be a potent suppressor of metastasis.

Clinical significance

MTA1 has been found to be upregulated in a number of cancer types, including breast cancer, prostate cancer, and colorectal cancer. Its overexpression has been linked to increased metastatic potential and poor prognosis in these cancers.

Research

Research into MTA1 is ongoing, with studies focusing on its role in cancer progression and potential as a target for cancer therapy.

See also

• MTA2
• MTA3
• Metastasis
• Gene expression
• Histone deacetylase

References

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