Famprofazone: Difference between revisions

Latest revision as of 11:16, 23 March 2025

Famprofazone[edit]

Famprofazone is a non-steroidal anti-inflammatory drug (NSAID) that is used for its analgesic and antipyretic properties. It is a prodrug that is metabolized in the body to produce methamphetamine and amphetamine, which contribute to its effects.

Pharmacology[edit]

Famprofazone is classified as a prodrug, meaning it is inactive in its administered form and requires metabolic conversion to become active. Once ingested, famprofazone is metabolized by the liver into its active components, including methamphetamine and amphetamine. These metabolites are responsible for the drug's analgesic and stimulant effects.

The presence of methamphetamine and amphetamine as metabolites can lead to positive results in drug tests for these substances, which is an important consideration for patients who may be subject to such testing.

Medical Uses[edit]

Famprofazone is primarily used for the relief of mild to moderate pain and to reduce fever. It is often prescribed for conditions such as arthritis, musculoskeletal pain, and other inflammatory conditions. Its effectiveness in pain relief is due to its ability to inhibit the synthesis of prostaglandins, which are compounds involved in the inflammatory response.

Side Effects[edit]

As with other NSAIDs, famprofazone can cause a range of side effects. Common side effects include gastrointestinal issues such as nausea, vomiting, and stomach pain. More serious side effects can include gastrointestinal bleeding, hypertension, and renal impairment.

The presence of methamphetamine and amphetamine as metabolites also raises concerns about potential abuse and addiction, as these substances are known for their stimulant effects.

Contraindications[edit]

Famprofazone should not be used in individuals with a history of substance abuse, particularly with stimulants. It is also contraindicated in patients with severe cardiovascular disease, hypertension, or renal impairment.

Related Pages[edit]

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-'''Famprofazone''' is a non-steroidal anti-inflammatory drug (NSAID) and analgesic. It is most commonly used in the treatment of [[pain]] and [[inflammation]] associated with conditions such as [[rheumatoid arthritis]], [[osteoarthritis]], and [[acute gout]]. Famprofazone is also used to relieve mild to moderate pain from [[headache]], [[toothache]], [[menstrual cramps]], and [[muscle aches]].
+== Famprofazone ==
-==Pharmacology==
+[[File:Famprofazone.png|thumb|right|Chemical structure of Famprofazone]]
-Famprofazone belongs to the class of drugs known as [[pyrazolones]]. It works by reducing the production of [[prostaglandins]], chemicals that cause inflammation, pain, and fever in the body. Famprofazone also has a weak [[antiplatelet]] effect, which can help to prevent blood clots.
-==Side Effects==
+'''Famprofazone''' is a non-steroidal anti-inflammatory drug (NSAID) that is used for its analgesic and antipyretic properties. It is a prodrug that is metabolized in the body to produce [[methamphetamine]] and [[amphetamine]], which contribute to its effects.
-Common side effects of famprofazone include [[nausea]], [[vomiting]], [[diarrhea]], and [[stomach upset]]. Less common but more serious side effects can include [[gastric ulcer]], [[bleeding]], and [[kidney damage]].
-==Contraindications==
+== Pharmacology ==
-Famprofazone is contraindicated in patients with known hypersensitivity to pyrazolones, patients with active [[peptic ulcer]] disease, and patients with severe [[liver disease]] or [[kidney disease]]. It should also be used with caution in patients with a history of [[heart disease]] or [[stroke]].
-==Interactions==
+Famprofazone is classified as a [[prodrug]], meaning it is inactive in its administered form and requires metabolic conversion to become active. Once ingested, famprofazone is metabolized by the liver into its active components, including methamphetamine and amphetamine. These metabolites are responsible for the drug's analgesic and stimulant effects.
-Famprofazone may interact with other drugs such as [[anticoagulants]], [[corticosteroids]], and [[selective serotonin reuptake inhibitors]] (SSRIs), increasing the risk of gastrointestinal bleeding. It may also interact with [[alcohol]], increasing the risk of stomach bleeding.
-==Availability==
+The presence of methamphetamine and amphetamine as metabolites can lead to positive results in drug tests for these substances, which is an important consideration for patients who may be subject to such testing.
-Famprofazone is available in many countries under various brand names. However, it is not approved for use in some countries, including the United States, due to concerns about its safety and effectiveness.
+== Medical Uses ==
+Famprofazone is primarily used for the relief of mild to moderate pain and to reduce fever. It is often prescribed for conditions such as [[arthritis]], [[musculoskeletal pain]], and other inflammatory conditions. Its effectiveness in pain relief is due to its ability to inhibit the synthesis of [[prostaglandins]], which are compounds involved in the inflammatory response.
+== Side Effects ==
+As with other NSAIDs, famprofazone can cause a range of side effects. Common side effects include gastrointestinal issues such as [[nausea]], [[vomiting]], and [[stomach pain]]. More serious side effects can include [[gastrointestinal bleeding]], [[hypertension]], and [[renal impairment]].
+The presence of methamphetamine and amphetamine as metabolites also raises concerns about potential [[abuse]] and [[addiction]], as these substances are known for their stimulant effects.
+== Contraindications ==
+Famprofazone should not be used in individuals with a history of [[substance abuse]], particularly with stimulants. It is also contraindicated in patients with severe [[cardiovascular disease]], [[hypertension]], or [[renal impairment]].
+== Related Pages ==
+* [[Non-steroidal anti-inflammatory drug]]
+* [[Prodrug]]
+* [[Methamphetamine]]
+* [[Amphetamine]]
 [[Category:Non-steroidal anti-inflammatory drugs]]
-[[Category:Analgesics]]
+[[Category:Prodrugs]]
-[[Category:Pyrazolones]]
-{{medicine-stub}}
-{{No image}}