Broparestrol: Difference between revisions

Latest revision as of 03:57, 13 February 2025

Broparestrol[edit]

Broparestrol is a synthetic, non-steroidal estrogen that was developed for use in hormone replacement therapy and other estrogen-related treatments. It belongs to the class of compounds known as stilbestrols, which are characterized by their structural similarity to the natural hormone estradiol.

Chemical Structure[edit]

Broparestrol is a derivative of diethylstilbestrol (DES), with a bromine atom added to its structure. This modification is intended to enhance its estrogenic activity and improve its pharmacokinetic properties. The chemical structure of Broparestrol is depicted in the image to the right.

Mechanism of Action[edit]

As an estrogen, Broparestrol binds to estrogen receptors in various tissues, including the breast, uterus, and bone. Upon binding, it activates these receptors, leading to the transcription of estrogen-responsive genes. This action mimics the effects of natural estrogens in the body, helping to alleviate symptoms associated with estrogen deficiency such as menopausal symptoms and osteoporosis.

Clinical Uses[edit]

Broparestrol has been used in the treatment of conditions that benefit from estrogen supplementation. These include:

Menopausal hormone therapy: To relieve symptoms such as hot flashes, vaginal atrophy, and osteoporosis.
Hypogonadism in women: To provide estrogenic effects in women with underdeveloped or non-functioning ovaries.
Certain types of breast cancer: In some cases, estrogens can be used to treat breast cancer, although this is less common with the advent of more targeted therapies.

Side Effects[edit]

Like other estrogens, Broparestrol can cause a range of side effects, including:

Nausea and vomiting
Breast tenderness
Headaches
Increased risk of thromboembolic events such as deep vein thrombosis and pulmonary embolism
Potential increased risk of certain types of cancer, particularly with long-term use

Pharmacokinetics[edit]

Broparestrol is administered orally and is well-absorbed from the gastrointestinal tract. It undergoes extensive first-pass metabolism in the liver, which can affect its bioavailability. The drug is metabolized primarily by the liver and excreted in the urine.

Related Compounds[edit]

Broparestrol is related to other synthetic estrogens, such as:

These compounds share similar mechanisms of action and clinical applications but differ in their potency, side effect profiles, and pharmacokinetic properties.

Related Pages[edit]

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-'''Broparestrol''' (INN; developmental code names LN-1643, R-2956), also known as '''4-chloro-α,α-diphenyl-β-(4-hydroxyphenyl)ethyl-1-ethanol''', is a synthetic, nonsteroidal [[estrogen]] that was never marketed. It is a [[selective estrogen receptor modulator]] (SERM), meaning it acts as an agonist of the [[estrogen receptor]] (ER) in some tissues and an antagonist in others. Broparestrol has been studied for various potential medical applications, including the treatment of [[prostate cancer]], [[breast cancer]], and as a component of [[hormone replacement therapy]] (HRT) for postmenopausal symptoms. However, its development was discontinued, and it is not available for medical use.
+{{DISPLAYTITLE:Broparestrol}}
-==Chemistry==
+== Broparestrol ==
-Broparestrol belongs to a class of compounds known as [[stilbenes]]. Stilbenes are organic compounds containing a 1,2-diphenylethylene moiety. Broparestrol's chemical structure is characterized by a chloro-substituted phenyl group, a hydroxy-substituted phenyl group, and an ethyl alcohol chain, making it a phenolic compound with estrogenic activity.
-==Mechanism of Action==
+[[File:Broparestrol.svg|thumb|right|Chemical structure of Broparestrol]]
-As a SERM, broparestrol's mechanism of action involves binding to estrogen receptors and modulating their activity. In tissues where it acts as an agonist, broparestrol can mimic the effects of [[estrogen]], promoting estrogenic responses. In contrast, in tissues where it acts as an antagonist, it can block the effects of estrogen, preventing estrogenic activity. This selective activity allows for the potential therapeutic use of broparestrol in conditions where estrogen's effects are desired in some tissues but not others.
-==Clinical Studies and Potential Uses==
+'''Broparestrol''' is a synthetic, non-steroidal [[estrogen]] that was developed for use in [[hormone replacement therapy]] and other estrogen-related treatments. It belongs to the class of compounds known as [[stilbestrols]], which are characterized by their structural similarity to the natural hormone [[estradiol]].
-Broparestrol has been investigated in clinical studies for its potential use in treating hormone-sensitive cancers, such as prostate and breast cancer. By acting as an antagonist in breast tissue, it was hoped that broparestrol could inhibit the growth of estrogen-dependent breast cancer cells. Similarly, its agonistic effects in other tissues were considered for the management of symptoms associated with estrogen deficiency, such as those experienced during menopause.
-Despite its potential, the development of broparestrol for clinical use was halted. The reasons for this are not well-documented but may include issues related to efficacy, safety, or the development of more effective treatments.
+== Chemical Structure ==
-==Safety and Side Effects==
+Broparestrol is a derivative of [[diethylstilbestrol]] (DES), with a bromine atom added to its structure. This modification is intended to enhance its estrogenic activity and improve its pharmacokinetic properties. The chemical structure of Broparestrol is depicted in the image to the right.
-The safety profile and side effects of broparestrol have not been fully characterized due to its limited clinical development. As with other SERMs, potential side effects could vary depending on its tissue-specific actions. Common side effects associated with SERMs include hot flashes, increased risk of venous thromboembolism, and endometrial changes.
-==Conclusion==
+== Mechanism of Action ==
-Broparestrol is a synthetic estrogen and SERM with potential applications in hormone-sensitive cancers and hormone replacement therapy. Despite initial research, its development was discontinued, and it remains a compound of historical and scientific interest rather than a therapeutic option.
-{{Pharmacology-stub}}
+As an estrogen, Broparestrol binds to [[estrogen receptors]] in various tissues, including the [[breast]], [[uterus]], and [[bone]]. Upon binding, it activates these receptors, leading to the transcription of estrogen-responsive genes. This action mimics the effects of natural estrogens in the body, helping to alleviate symptoms associated with [[estrogen deficiency]] such as [[menopausal symptoms]] and [[osteoporosis]].
-[[Category:Selective estrogen receptor modulators]]
+== Clinical Uses ==
-[[Category:Stilbenes]]
-[[Category:Chloroarenes]]
+Broparestrol has been used in the treatment of conditions that benefit from estrogen supplementation. These include:
-[[Category:Phenol ethers]]
-[[Category:Abandoned drugs]]
+* [[Menopausal hormone therapy]]: To relieve symptoms such as [[hot flashes]], [[vaginal atrophy]], and [[osteoporosis]].
-{{No image}}
+* [[Hypogonadism]] in women: To provide estrogenic effects in women with underdeveloped or non-functioning ovaries.
+* Certain types of [[breast cancer]]: In some cases, estrogens can be used to treat breast cancer, although this is less common with the advent of more targeted therapies.
+== Side Effects ==
+Like other estrogens, Broparestrol can cause a range of side effects, including:
+* [[Nausea]] and [[vomiting]]
+* [[Breast tenderness]]
+* [[Headaches]]
+* Increased risk of [[thromboembolic events]] such as [[deep vein thrombosis]] and [[pulmonary embolism]]
+* Potential increased risk of certain types of [[cancer]], particularly with long-term use
+== Pharmacokinetics ==
+Broparestrol is administered orally and is well-absorbed from the gastrointestinal tract. It undergoes extensive [[first-pass metabolism]] in the [[liver]], which can affect its bioavailability. The drug is metabolized primarily by the liver and excreted in the urine.
+== Related Compounds ==
+Broparestrol is related to other synthetic estrogens, such as:
+* [[Diethylstilbestrol]] (DES)
+* [[Hexestrol]]
+* [[Methestrol]]
+These compounds share similar mechanisms of action and clinical applications but differ in their potency, side effect profiles, and pharmacokinetic properties.
+== Related Pages ==
+* [[Estrogen]]
+* [[Hormone replacement therapy]]
+* [[Diethylstilbestrol]]
+* [[Menopause]]
+[[Category:Estrogens]]
+[[Category:Hormone therapy]]
+[[Category:Pharmacology]]