Trestolone: Difference between revisions
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{{DISPLAYTITLE:Trestolone}} | |||
== Trestolone == | == Trestolone == | ||
[[File:Trestolone_structure.svg|thumb|right|Chemical structure of Trestolone]] | |||
[[ | '''Trestolone''', also known as 7_-methyl-19-nortestosterone (MENT), is a synthetic [[androgen]] and [[anabolic steroid]] (AAS) that was developed for potential use in [[male contraception]] and [[hormone replacement therapy]]. It is a potent [[androgen receptor]] agonist and has been studied for its effects on [[muscle growth]], [[spermatogenesis]], and [[libido]]. | ||
== Chemical Properties == | |||
Trestolone is a derivative of [[nandrolone]], with a methyl group added at the 7_ position. This modification increases its [[androgenic]] and [[anabolic]] activity compared to nandrolone. The chemical structure of trestolone is depicted in the image to the right. | |||
== | == Mechanism of Action == | ||
Trestolone acts by binding to the androgen receptor, which is a type of [[nuclear receptor]] that regulates the expression of specific genes. Upon binding, trestolone activates the receptor, leading to increased [[protein synthesis]] and muscle growth. It also suppresses the production of [[gonadotropins]] from the [[pituitary gland]], which reduces [[testosterone]] production and [[spermatogenesis]]. | |||
== | == Clinical Applications == | ||
Trestolone | Trestolone has been investigated for use in male contraception due to its ability to suppress sperm production while maintaining [[libido]] and [[muscle mass]]. It has also been studied for [[hormone replacement therapy]] in men with low testosterone levels. However, its use in clinical practice is limited, and it is not approved for medical use in most countries. | ||
== | == Side Effects == | ||
As with other anabolic steroids, trestolone can cause a range of side effects, including [[acne]], [[gynecomastia]], [[hair loss]], and [[liver toxicity]]. Long-term use can lead to [[cardiovascular disease]], [[infertility]], and [[psychological effects]] such as [[aggression]] and [[mood swings]]. | |||
== | == Related Compounds == | ||
Trestolone | Trestolone is related to other anabolic steroids such as [[nandrolone]], [[testosterone]], and [[trenbolone]]. These compounds share similar mechanisms of action but differ in their potency and side effect profiles. | ||
== Research and Development == | == Research and Development == | ||
Research on trestolone continues, with studies focusing on its potential as a male contraceptive and its effects on muscle growth and body composition. Its unique properties make it a subject of interest in the field of [[endocrinology]] and [[pharmacology]]. | |||
== Related Pages == | == Related Pages == | ||
* [[Androgen receptor]] | |||
* [[Anabolic steroid]] | * [[Anabolic steroid]] | ||
* [[ | * [[Male contraception]] | ||
* [[ | * [[Hormone replacement therapy]] | ||
[[Category:Androgens and anabolic steroids]] | [[Category:Androgens and anabolic steroids]] | ||
[[Category: | [[Category:Hormonal contraception]] | ||
Latest revision as of 11:21, 15 February 2025
Trestolone[edit]
Trestolone, also known as 7_-methyl-19-nortestosterone (MENT), is a synthetic androgen and anabolic steroid (AAS) that was developed for potential use in male contraception and hormone replacement therapy. It is a potent androgen receptor agonist and has been studied for its effects on muscle growth, spermatogenesis, and libido.
Chemical Properties[edit]
Trestolone is a derivative of nandrolone, with a methyl group added at the 7_ position. This modification increases its androgenic and anabolic activity compared to nandrolone. The chemical structure of trestolone is depicted in the image to the right.
Mechanism of Action[edit]
Trestolone acts by binding to the androgen receptor, which is a type of nuclear receptor that regulates the expression of specific genes. Upon binding, trestolone activates the receptor, leading to increased protein synthesis and muscle growth. It also suppresses the production of gonadotropins from the pituitary gland, which reduces testosterone production and spermatogenesis.
Clinical Applications[edit]
Trestolone has been investigated for use in male contraception due to its ability to suppress sperm production while maintaining libido and muscle mass. It has also been studied for hormone replacement therapy in men with low testosterone levels. However, its use in clinical practice is limited, and it is not approved for medical use in most countries.
Side Effects[edit]
As with other anabolic steroids, trestolone can cause a range of side effects, including acne, gynecomastia, hair loss, and liver toxicity. Long-term use can lead to cardiovascular disease, infertility, and psychological effects such as aggression and mood swings.
Related Compounds[edit]
Trestolone is related to other anabolic steroids such as nandrolone, testosterone, and trenbolone. These compounds share similar mechanisms of action but differ in their potency and side effect profiles.
Research and Development[edit]
Research on trestolone continues, with studies focusing on its potential as a male contraceptive and its effects on muscle growth and body composition. Its unique properties make it a subject of interest in the field of endocrinology and pharmacology.
