LNCaP: Difference between revisions
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{{Short description|Human prostate cancer cell line}} | |||
'''LNCaP''' is a human [[prostate cancer]] cell line commonly used in [[cancer research]]. It was established from a metastatic lesion of human prostatic adenocarcinoma in the left supraclavicular lymph node of a 50-year-old Caucasian male. LNCaP cells are androgen-sensitive, meaning | == Overview == | ||
[[File:LNCaP.jpg|thumb|right|LNCaP cells under a microscope]] | |||
'''LNCaP''' is a human [[prostate cancer]] cell line commonly used in [[cancer research]]. It was established from a metastatic lesion of human prostatic adenocarcinoma in the left supraclavicular lymph node of a 50-year-old Caucasian male. LNCaP cells are androgen-sensitive, meaning their growth is stimulated by [[androgens]], which are male hormones such as [[testosterone]]. | |||
==Characteristics== | == Characteristics == | ||
LNCaP cells exhibit several key characteristics that make them | LNCaP cells exhibit several key characteristics that make them valuable for research: | ||
* '''Androgen Sensitivity''': LNCaP cells | * '''Androgen Sensitivity''': LNCaP cells require androgens for optimal growth, making them a model for studying androgen-dependent prostate cancer. | ||
* '''PSA Production''': These cells produce [[prostate-specific antigen]] (PSA), a protein used as a marker in prostate cancer diagnosis and monitoring. | |||
* '''Mutation Profile''': LNCaP cells have a mutation in the [[androgen receptor]] gene, which affects their response to androgens. | |||
== Applications in Research == | |||
[[File:Comparison_of_cancer_cell_lines.png|thumb|left|Comparison of various cancer cell lines, including LNCaP]] | |||
LNCaP cells are widely used in prostate cancer research to: | |||
* | * Study the mechanisms of androgen receptor signaling and its role in prostate cancer progression. | ||
* Investigate the effects of anti-androgen drugs and other therapeutic agents. | |||
* Explore the molecular pathways involved in prostate cancer metastasis and resistance to therapy. | |||
== Comparison with Other Cell Lines == | |||
LNCaP cells are often compared with other prostate cancer cell lines such as [[PC-3]] and [[DU145]]. Unlike LNCaP, PC-3 and DU145 are androgen-independent, meaning they do not require androgens for growth. This difference makes LNCaP particularly useful for studying the transition from androgen-dependent to androgen-independent prostate cancer. | |||
== Limitations == | |||
While LNCaP cells are a valuable tool in prostate cancer research, they have limitations: | |||
==Limitations== | |||
While LNCaP cells are a valuable tool, they have limitations: | |||
* '''Genetic Drift''': Over time, LNCaP cells can undergo genetic changes that may affect experimental outcomes. | * '''Genetic Drift''': Over time, LNCaP cells can undergo genetic changes that may affect experimental outcomes. | ||
* '''Limited Metastatic Potential''': LNCaP cells have a lower metastatic potential compared to other cell lines, which may limit their use in studying advanced prostate cancer. | |||
== Related pages == | |||
== | |||
* [[Prostate cancer]] | * [[Prostate cancer]] | ||
* [[Androgen receptor]] | * [[Androgen receptor]] | ||
* [[Prostate-specific antigen]] | * [[Prostate-specific antigen]] | ||
* [[PC-3]] | |||
* [[DU145]] | |||
== See also == | |||
* [[Cancer cell line]] | |||
* [[Androgen deprivation therapy]] | * [[Androgen deprivation therapy]] | ||
* [[ | * [[Hormone therapy (oncology)]] | ||
[[Category:Prostate cancer]] | [[Category:Prostate cancer]] | ||
[[Category:Cell lines | [[Category:Cell lines used in cancer research]] | ||
Latest revision as of 20:30, 21 February 2025
Human prostate cancer cell line
Overview[edit]
LNCaP is a human prostate cancer cell line commonly used in cancer research. It was established from a metastatic lesion of human prostatic adenocarcinoma in the left supraclavicular lymph node of a 50-year-old Caucasian male. LNCaP cells are androgen-sensitive, meaning their growth is stimulated by androgens, which are male hormones such as testosterone.
Characteristics[edit]
LNCaP cells exhibit several key characteristics that make them valuable for research:
- Androgen Sensitivity: LNCaP cells require androgens for optimal growth, making them a model for studying androgen-dependent prostate cancer.
- PSA Production: These cells produce prostate-specific antigen (PSA), a protein used as a marker in prostate cancer diagnosis and monitoring.
- Mutation Profile: LNCaP cells have a mutation in the androgen receptor gene, which affects their response to androgens.
Applications in Research[edit]
LNCaP cells are widely used in prostate cancer research to:
- Study the mechanisms of androgen receptor signaling and its role in prostate cancer progression.
- Investigate the effects of anti-androgen drugs and other therapeutic agents.
- Explore the molecular pathways involved in prostate cancer metastasis and resistance to therapy.
Comparison with Other Cell Lines[edit]
LNCaP cells are often compared with other prostate cancer cell lines such as PC-3 and DU145. Unlike LNCaP, PC-3 and DU145 are androgen-independent, meaning they do not require androgens for growth. This difference makes LNCaP particularly useful for studying the transition from androgen-dependent to androgen-independent prostate cancer.
Limitations[edit]
While LNCaP cells are a valuable tool in prostate cancer research, they have limitations:
- Genetic Drift: Over time, LNCaP cells can undergo genetic changes that may affect experimental outcomes.
- Limited Metastatic Potential: LNCaP cells have a lower metastatic potential compared to other cell lines, which may limit their use in studying advanced prostate cancer.
