Cefetamet: Difference between revisions

Latest revision as of 03:45, 13 February 2025

An article about the antibiotic Cefetamet

Cefetamet[edit]

Cefetamet is a third-generation cephalosporin antibiotic used to treat a variety of bacterial infections. It is known for its broad-spectrum activity against both Gram-positive and Gram-negative organisms. Cefetamet is particularly effective against respiratory tract infections, urinary tract infections, and skin and soft tissue infections.

Mechanism of Action[edit]

Cefetamet works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which are essential for the cross-linking of the peptidoglycan layer. This inhibition leads to the weakening of the cell wall and ultimately causes cell lysis and death of the bacteria.

Pharmacokinetics[edit]

Cefetamet is administered orally and is absorbed in the gastrointestinal tract. It is then distributed throughout the body, reaching effective concentrations in various tissues and fluids. The drug is primarily excreted unchanged in the urine, making it particularly useful for treating urinary tract infections.

Clinical Uses[edit]

Cefetamet is indicated for the treatment of several types of infections, including:

Side Effects[edit]

Common side effects of cefetamet include gastrointestinal disturbances such as nausea, vomiting, and diarrhea. Some patients may experience allergic reactions, including rash, pruritus, and in rare cases, anaphylaxis.

Resistance[edit]

Bacterial resistance to cefetamet can occur through various mechanisms, such as the production of beta-lactamase enzymes that degrade the antibiotic, or alterations in PBPs that reduce drug binding. Resistance is a growing concern and underscores the importance of appropriate antibiotic use.

Related pages[edit]

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-'''Cefetamet''' is a third-generation [[cephalosporin antibiotic]] used in the treatment of bacterial infections. It is effective against a wide range of Gram-positive and Gram-negative bacteria, making it a valuable option in the arsenal against bacterial infections. Cefetamet's mechanism of action involves inhibiting bacterial cell wall synthesis, leading to the death of the bacteria. This antibiotic is particularly useful for treating respiratory tract infections, urinary tract infections, and skin infections.
+{{Short description|An article about the antibiotic Cefetamet}}
-==Medical Uses==
+==Cefetamet==
-Cefetamet is indicated for the treatment of various bacterial infections, including:
+[[File:Cefetamet.png|thumb|right|Chemical structure of Cefetamet]]
-* [[Acute bacterial exacerbations of chronic bronchitis]]
+'''Cefetamet''' is a [[third-generation cephalosporin]] [[antibiotic]] used to treat a variety of bacterial infections. It is known for its broad-spectrum activity against both [[Gram-positive bacteria|Gram-positive]] and [[Gram-negative bacteria|Gram-negative]] organisms. Cefetamet is particularly effective against [[respiratory tract infections]], [[urinary tract infections]], and [[skin and soft tissue infections]].
-* [[Uncomplicated urinary tract infections]] (UTIs)
-* [[Otitis media]] (middle ear infections)
-* [[Pharyngitis]] and [[tonsillitis]]
-* [[Sinusitis]]
-* [[Skin and skin structure infections]]
-It is important to note that the use of cefetamet should be guided by susceptibility patterns of the local bacterial populations and specific patient needs.
+==Mechanism of Action==
+Cefetamet works by inhibiting bacterial [[cell wall]] synthesis. It binds to [[penicillin-binding proteins]] (PBPs) located inside the bacterial cell wall, which are essential for the cross-linking of the [[peptidoglycan]] layer. This inhibition leads to the weakening of the cell wall and ultimately causes [[cell lysis]] and death of the bacteria.
-==Pharmacology==
+==Pharmacokinetics==
-===Mechanism of Action===
+Cefetamet is administered orally and is absorbed in the [[gastrointestinal tract]]. It is then distributed throughout the body, reaching effective concentrations in various tissues and fluids. The drug is primarily excreted unchanged in the [[urine]], making it particularly useful for treating urinary tract infections.
-Cefetamet inhibits the synthesis of the bacterial cell wall by binding to penicillin-binding proteins (PBPs), which are essential for cell wall integrity. This action ultimately leads to bacterial cell lysis and death.
-===Pharmacokinetics===
+==Clinical Uses==
-Cefetamet is well absorbed from the gastrointestinal tract, with its bioavailability being significantly enhanced when taken with food. It is metabolized minimally and excreted primarily through the kidneys. Therefore, dose adjustments may be necessary in patients with renal impairment.
+Cefetamet is indicated for the treatment of several types of infections, including:
+* [[Acute bronchitis]]
-==Adverse Effects==
+* [[Pneumonia]]
-The adverse effects of cefetamet are similar to those of other cephalosporins and may include:
+* [[Sinusitis]]
-* [[Diarrhea]]
+* [[Pharyngitis]]
-* [[Nausea]] and vomiting
+* [[Cystitis]]
-* [[Rash]]
+* [[Pyelonephritis]]
-* [[Eosinophilia]]
+* [[Cellulitis]]
-* [[Transaminase elevations]]
-Serious adverse effects are rare but can include [[anaphylaxis]], [[Clostridium difficile-associated diarrhea]], and [[Stevens-Johnson syndrome]].
-==Drug Interactions==
-Cefetamet may interact with other medications, such as:
-* [[Probenecid]], which can increase the concentration of cefetamet by decreasing its renal excretion
-* [[Anticoagulants]] (e.g., warfarin), as cefetamet can potentiate the anticoagulant effect
-Patients should inform their healthcare provider of all medications they are taking to avoid potential drug interactions.
+==Side Effects==
+Common side effects of cefetamet include [[gastrointestinal disturbances]] such as [[nausea]], [[vomiting]], and [[diarrhea]]. Some patients may experience [[allergic reactions]], including [[rash]], [[pruritus]], and in rare cases, [[anaphylaxis]].
-==Contraindications==
+==Resistance==
-Cefetamet is contraindicated in patients with a known allergy to cephalosporin antibiotics. Caution is advised in patients with a history of [[penicillin allergy]], as cross-reactivity may occur.
+Bacterial resistance to cefetamet can occur through various mechanisms, such as the production of [[beta-lactamase]] enzymes that degrade the antibiotic, or alterations in PBPs that reduce drug binding. Resistance is a growing concern and underscores the importance of appropriate antibiotic use.
-==See Also==
+==Related pages==
-* [[Antibiotics]]
 * [[Cephalosporin]]
-* [[Bacterial infection]]
+* [[Antibiotic resistance]]
+* [[Beta-lactam antibiotic]]
+[[Category:Cephalosporin antibiotics]]
 [[Category:Antibiotics]]
-[[Category:Cephalosporin antibiotics]]
-[[Category:Third-generation cephalosporins]]
-{{Medicine-stub}}