Precursor T-lymphoblastic lymphoma: Difference between revisions
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{{Infobox disease | |||
| name = Precursor T-lymphoblastic lymphoma | |||
| image = <!-- Image removed --> | |||
| caption = <!-- Caption removed --> | |||
| field = [[Hematology]] | |||
| symptoms = [[Lymphadenopathy]], [[fever]], [[night sweats]], [[weight loss]] | |||
| complications = [[Tumor lysis syndrome]], [[mediastinal mass]] | |||
| onset = Typically in [[adolescents]] and [[young adults]] | |||
| types = [[T-cell lymphoma]] | |||
| causes = [[Genetic mutations]] | |||
| risks = [[Family history]], [[immunodeficiency]] | |||
| diagnosis = [[Biopsy]], [[immunophenotyping]] | |||
| treatment = [[Chemotherapy]], [[radiation therapy]] | |||
| prognosis = Variable, depends on stage and response to treatment | |||
| frequency = Rare | |||
}} | |||
== | '''Precursor T-lymphoblastic lymphoma''' is a type of [[non-Hodgkin lymphoma]] that arises from immature [[T-cells]]. It is considered a high-grade [[lymphoma]] and is closely related to [[acute lymphoblastic leukemia]] (ALL). This condition primarily affects [[adolescents]] and [[young adults]], with a higher prevalence in [[males]]. | ||
==Pathophysiology== | |||
Precursor T-lymphoblastic lymphoma is characterized by the proliferation of immature [[T-lymphocytes]] in the [[thymus]] or other [[lymphoid tissues]]. These cells can infiltrate the [[bone marrow]], [[lymph nodes]], and other organs, leading to the clinical manifestations of the disease. | |||
==Clinical Presentation== | ==Clinical Presentation== | ||
Patients with T- | Patients with precursor T-lymphoblastic lymphoma often present with symptoms such as [[lymphadenopathy]], [[fever]], [[night sweats]], and [[weight loss]]. A [[mediastinal mass]] is a common finding, which can cause respiratory symptoms due to compression of the [[trachea]] or other structures in the [[thoracic cavity]]. | ||
==Diagnosis== | ==Diagnosis== | ||
The diagnosis of T- | The diagnosis of precursor T-lymphoblastic lymphoma is typically made through a combination of [[biopsy]] and [[immunophenotyping]]. A biopsy of the affected tissue will show a proliferation of immature [[T-cells]], and immunophenotyping can confirm the T-cell origin of the lymphoma. | ||
==Treatment== | ==Treatment== | ||
Treatment for precursor T-lymphoblastic lymphoma usually involves intensive [[chemotherapy]] regimens similar to those used for [[acute lymphoblastic leukemia]]. [[Radiation therapy]] may also be used, particularly if there is a large [[mediastinal mass]]. | |||
==Prognosis== | ==Prognosis== | ||
The prognosis | The prognosis for patients with precursor T-lymphoblastic lymphoma varies depending on several factors, including the stage of the disease at diagnosis and the patient's response to treatment. Early diagnosis and aggressive treatment can improve outcomes. | ||
[[ | ==See also== | ||
* [[T-cell lymphoma]] | |||
* [[Acute lymphoblastic leukemia]] | * [[Acute lymphoblastic leukemia]] | ||
* [[Non-Hodgkin lymphoma]] | * [[Non-Hodgkin lymphoma]] | ||
==References== | |||
{{Reflist}} | |||
==External links== | |||
* [https://www.cancer.gov/types/lymphoma/hp/adult-nhl-treatment-pdq National Cancer Institute - Adult Non-Hodgkin Lymphoma Treatment] | |||
[[Category:Hematology]] | |||
[[Category:Lymphoma]] | [[Category:Lymphoma]] | ||
[[Category: | [[Category:Rare diseases]] | ||
[[Category: | [[Category:Oncology]] | ||
Latest revision as of 16:53, 29 December 2024
| Precursor T-lymphoblastic lymphoma | |
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| ICD-9 | |
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| MeSH ID | |
Precursor T-lymphoblastic lymphoma is a type of non-Hodgkin lymphoma that arises from immature T-cells. It is considered a high-grade lymphoma and is closely related to acute lymphoblastic leukemia (ALL). This condition primarily affects adolescents and young adults, with a higher prevalence in males.
Pathophysiology[edit]
Precursor T-lymphoblastic lymphoma is characterized by the proliferation of immature T-lymphocytes in the thymus or other lymphoid tissues. These cells can infiltrate the bone marrow, lymph nodes, and other organs, leading to the clinical manifestations of the disease.
Clinical Presentation[edit]
Patients with precursor T-lymphoblastic lymphoma often present with symptoms such as lymphadenopathy, fever, night sweats, and weight loss. A mediastinal mass is a common finding, which can cause respiratory symptoms due to compression of the trachea or other structures in the thoracic cavity.
Diagnosis[edit]
The diagnosis of precursor T-lymphoblastic lymphoma is typically made through a combination of biopsy and immunophenotyping. A biopsy of the affected tissue will show a proliferation of immature T-cells, and immunophenotyping can confirm the T-cell origin of the lymphoma.
Treatment[edit]
Treatment for precursor T-lymphoblastic lymphoma usually involves intensive chemotherapy regimens similar to those used for acute lymphoblastic leukemia. Radiation therapy may also be used, particularly if there is a large mediastinal mass.
Prognosis[edit]
The prognosis for patients with precursor T-lymphoblastic lymphoma varies depending on several factors, including the stage of the disease at diagnosis and the patient's response to treatment. Early diagnosis and aggressive treatment can improve outcomes.
See also[edit]
References[edit]
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