IRX4: Difference between revisions
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'''IRX4''' is | |||
{{Infobox gene | |||
| name = IRX4 | |||
| symbol = IRX4 | |||
| HGNCid = 6127 | |||
| chromosome = 5 | |||
| arm = q | |||
| band = 35.1 | |||
}} | |||
'''IRX4''' is a member of the [[Iroquois homeobox gene family]], which plays a crucial role in the development of the [[heart]] and [[central nervous system]]. The IRX4 gene is located on [[chromosome 5]] and is involved in the regulation of [[cardiac muscle]] differentiation and [[ventricular]] development. | |||
== Function == | == Function == | ||
IRX4 is a transcription factor that binds to specific DNA sequences, thereby controlling the expression of genes involved in [[cardiogenesis]]. It is essential for the proper formation of the [[ventricular myocardium]] and has been implicated in the development of [[congenital heart defects]]. | |||
== Clinical Significance == | == Clinical Significance == | ||
Mutations | Mutations or dysregulation of the IRX4 gene have been associated with various [[cardiovascular diseases]], including [[cardiomyopathy]] and [[heart failure]]. Research suggests that IRX4 may also play a role in the development of [[prostate cancer]], as it is involved in the regulation of [[androgen receptor]] signaling pathways. | ||
== Research == | == Research == | ||
Studies on IRX4 have focused on its role in heart development and disease. Animal models have demonstrated that loss of IRX4 function leads to abnormal heart development and [[ventricular septal defects]]. Ongoing research aims to further elucidate the molecular mechanisms by which IRX4 regulates cardiac gene expression and its potential as a therapeutic target in heart disease. | |||
[[ | |||
== See Also == | == See Also == | ||
* [[ | * [[Homeobox]] | ||
* [[ | * [[Transcription factor]] | ||
* [[ | * [[Cardiogenesis]] | ||
== References == | == References == | ||
<references /> | <references /> | ||
[[Category:Genes]] | == External Links == | ||
[[Category: | * [https://www.ncbi.nlm.nih.gov/gene/IRX4 IRX4 Gene - NCBI] | ||
[[Category: | * [https://www.genecards.org/cgi-bin/carddisp.pl?gene=IRX4 IRX4 Gene - GeneCards] | ||
[[Category:Genes on human chromosome 5]] | |||
[[Category:Transcription factors]] | |||
[[Category:Developmental genes and proteins]] | |||
Latest revision as of 20:45, 30 December 2024
| Symbol | IRX4 |
|---|---|
| HGNC ID | 6127 |
| Alternative symbols | – |
| Entrez Gene | – |
| OMIM | – |
| RefSeq | – |
| UniProt | – |
| Chromosome | 5q35.1 |
| Locus supplementary data | – |
IRX4 is a member of the Iroquois homeobox gene family, which plays a crucial role in the development of the heart and central nervous system. The IRX4 gene is located on chromosome 5 and is involved in the regulation of cardiac muscle differentiation and ventricular development.
Function[edit]
IRX4 is a transcription factor that binds to specific DNA sequences, thereby controlling the expression of genes involved in cardiogenesis. It is essential for the proper formation of the ventricular myocardium and has been implicated in the development of congenital heart defects.
Clinical Significance[edit]
Mutations or dysregulation of the IRX4 gene have been associated with various cardiovascular diseases, including cardiomyopathy and heart failure. Research suggests that IRX4 may also play a role in the development of prostate cancer, as it is involved in the regulation of androgen receptor signaling pathways.
Research[edit]
Studies on IRX4 have focused on its role in heart development and disease. Animal models have demonstrated that loss of IRX4 function leads to abnormal heart development and ventricular septal defects. Ongoing research aims to further elucidate the molecular mechanisms by which IRX4 regulates cardiac gene expression and its potential as a therapeutic target in heart disease.
See Also[edit]
References[edit]
<references />
