Somitomere: Difference between revisions

General Information
Latin
Greek
TA98
TA2
FMA
Details
System	Musculoskeletal system
Artery
Vein
Nerve
Lymphatic drainage
Precursor	Paraxial mesoderm
Function
Identifiers
Clinical significance
Notes

Latest revision as of 20:32, 30 December 2024

A somitomere is a segmental unit of the paraxial mesoderm in the developing embryo. Somitomeres are the precursors to somites, which are essential for the segmentation of the vertebrate body plan.

Development[edit]

Somitomeres form in a cranial-to-caudal sequence along the neural tube and are initially visible as mesodermal condensations. They are organized into pairs on either side of the developing neural tube. As development progresses, somitomeres further differentiate into somites, which will give rise to the vertebrae, ribs, and associated muscles.

Function[edit]

Somitomeres play a crucial role in the early segmentation of the embryo, contributing to the formation of the axial skeleton, skeletal muscle, and dermis. They are involved in the patterning and organization of the musculoskeletal system.

Clinical significance[edit]

Abnormal development of somitomeres can lead to congenital anomalies such as scoliosis and other vertebral malformations. Understanding the molecular mechanisms governing somitomere formation and differentiation is important for elucidating the causes of these conditions.

References[edit]

External links[edit]

Wikimd - Somitomere

@@ Line 1: / Line 1: @@
-'''Somitomere''' is a term used in [[Embryology]] to describe the early divisions of the [[Mesoderm]] in the developing [[Embryo]]. These divisions, or segments, are the precursors to the [[Somites]], which later give rise to important structures in the body such as the [[Vertebrae]], [[Ribs]], and part of the [[Skull]].
-==Development==
+{{Infobox anatomy
-The process of somitomere formation begins during the third week of [[Human embryogenesis|embryonic development]]. The [[Paraxial mesoderm]], located on either side of the [[Neural tube]], begins to segment into blocks. These blocks, or somitomeres, are initially spherical in shape and are not clearly separated from each other.
+| Name         = Somitomere
+| Latin        =
+| Image        =
+| Caption      =
+| Precursor    = [[Paraxial mesoderm]]
+| GivesRiseTo  = [[Somite]]
+| System       = [[Musculoskeletal system]]
+| MeshName     =
+| MeshNumber   =
+}}
-[[File:Somitomere.jpg|thumb|right|300px|Somitomeres in a developing embryo]]
+A '''somitomere''' is a segmental unit of the [[paraxial mesoderm]] in the developing [[embryo]]. Somitomeres are the precursors to [[somites]], which are essential for the segmentation of the [[vertebrate]] body plan.
-As development progresses, the somitomeres undergo a process of [[Morphogenesis|morphogenetic]] change, becoming more elongated and clearly separated. This process is regulated by a variety of [[Gene expression|genetic factors]], including the [[Hox gene]] family and [[Notch signaling pathway]].
+== Development ==
+Somitomeres form in a cranial-to-caudal sequence along the [[neural tube]] and are initially visible as mesodermal condensations. They are organized into pairs on either side of the developing [[neural tube]]. As development progresses, somitomeres further differentiate into somites, which will give rise to the [[vertebrae]], [[ribs]], and associated [[muscles]].
-==Function==
+== Function ==
-The somitomeres give rise to the somites, which are the building blocks of the [[Axial skeleton]]. Each somite will eventually differentiate into three parts: the [[Sclerotome]], which forms the vertebrae and ribs; the [[Myotome]], which forms the skeletal muscle; and the [[Dermatome (embryology)|Dermatome]], which forms the dermis of the skin.
+Somitomeres play a crucial role in the early segmentation of the [[embryo]], contributing to the formation of the [[axial skeleton]], [[skeletal muscle]], and [[dermis]]. They are involved in the patterning and organization of the [[musculoskeletal system]].
-In addition to their role in skeletal and muscular development, somitomeres also play a crucial role in the patterning of the [[Central nervous system]]. They are involved in the segmentation of the [[Rhombomere]]s, which are the building blocks of the [[Hindbrain]].
+== Clinical significance ==
+Abnormal development of somitomeres can lead to congenital anomalies such as [[scoliosis]] and other vertebral malformations. Understanding the molecular mechanisms governing somitomere formation and differentiation is important for elucidating the causes of these conditions.
-==See also==
+== See also ==
 * [[Somite]]
-* [[Mesoderm]]
+* [[Paraxial mesoderm]]
 * [[Embryogenesis]]
-* [[Hox gene]]
+* [[Neural tube]]
-* [[Notch signaling pathway]]
-==References==
+== References ==
-<references />
+{{Reflist}}
+== External links ==
+* [https://www.wikimd.com/wiki/Somitomere Wikimd - Somitomere]
 [[Category:Embryology]]
 [[Category:Developmental biology]]
-[[Category:Anatomy]]
+[[Category:Musculoskeletal system]]
-{{anatomy-stub}}