Taleranol: Difference between revisions

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'''Taleranol''' is a [[synthetic estrogen]] that was developed in the 1960s. It is a member of the [[steroidal estrogen]] class of drugs, which also includes substances such as [[estradiol]], [[estriol]], and [[ethinylestradiol]]. Taleranol is not currently used in medical practice, but it has been studied for potential uses in the treatment of [[menopausal symptoms]] and [[osteoporosis]].
{{Short description|A synthetic estrogen used in veterinary medicine}}
{{Drugbox
| verifiedfields = changed
| verifiedrevid = 477002123
| IUPAC_name = (3S,8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
| image = Taleranol.svg
| image_size = 200px
| image_alt = Structural formula of Taleranol
}}


== History ==
'''Taleranol''' is a synthetic [[estrogen]] that is primarily used in [[veterinary medicine]]. It is a nonsteroidal estrogen that belongs to the class of compounds known as [[mycoestrogens]], which are naturally occurring estrogens produced by [[fungi]].


Taleranol was first synthesized in the 1960s by the pharmaceutical company [[Eli Lilly and Company|Eli Lilly]]. It was one of many synthetic estrogens developed during this time period, as researchers sought to create drugs that could mimic the effects of natural estrogens without causing unwanted side effects.
==Chemical structure and properties==
[[File:Taleranol.svg|thumb|right|200px|Structural formula of Taleranol]]
Taleranol is a derivative of the mycoestrogen [[zearalenone]], which is produced by several species of [[Fusarium]] fungi. The chemical structure of taleranol is characterized by a cyclopenta[a]phenanthrene skeleton, which is typical of many steroidal estrogens, although taleranol itself is nonsteroidal.


== Pharmacology ==
==Mechanism of action==
Taleranol exerts its effects by binding to [[estrogen receptors]] in target tissues. This binding mimics the action of endogenous estrogens, leading to the activation of estrogen-responsive genes. The primary physiological effects of taleranol are similar to those of natural estrogens, including the promotion of growth and development of female secondary sexual characteristics and the regulation of the [[menstrual cycle]].


Like other steroidal estrogens, taleranol works by binding to [[estrogen receptors]] in the body. These receptors are found in many different tissues, including the [[breast]], [[uterus]], [[brain]], and [[bone]]. When taleranol binds to these receptors, it triggers a series of biochemical reactions that can lead to various physiological effects.
==Uses in veterinary medicine==
In veterinary practice, taleranol is used as a growth promoter in livestock, particularly in cattle. It is administered to improve feed efficiency and promote weight gain. The use of taleranol in animals is regulated to ensure that residues do not remain in meat products intended for human consumption.


== Potential Uses ==
==Safety and regulation==
The use of taleranol, like other growth-promoting agents, is subject to strict regulatory controls. In some countries, the use of synthetic estrogens in food-producing animals is banned or restricted due to concerns about potential health risks to humans. Monitoring programs are in place to detect residues of taleranol and other similar compounds in meat products.


Although taleranol is not currently used in medical practice, it has been studied for potential uses in the treatment of menopausal symptoms and osteoporosis. Some research suggests that it may be effective in reducing [[hot flashes]], [[night sweats]], and other symptoms associated with menopause. Other studies have suggested that it may help to prevent bone loss in postmenopausal women, potentially reducing the risk of osteoporosis.
==Related pages==
* [[Estrogen]]
* [[Zearalenone]]
* [[Veterinary medicine]]
* [[Growth hormone]]


== Safety and Side Effects ==
Like other synthetic estrogens, taleranol has been associated with a number of potential side effects. These can include [[nausea]], [[vomiting]], [[breast tenderness]], and [[menstrual irregularities]]. In addition, long-term use of synthetic estrogens has been linked to an increased risk of certain types of [[cancer]], including [[breast cancer]] and [[endometrial cancer]].
== See Also ==
* [[Estradiol]]
* [[Estriol]]
* [[Ethinylestradiol]]
* [[Menopause]]
* [[Osteoporosis]]
[[Category:Drugs]]
[[Category:Estrogens]]
[[Category:Estrogens]]
[[Category:Synthetic estrogens]]
[[Category:Veterinary drugs]]
{{medicine-stub}}
[[Category:Mycoestrogens]]

Latest revision as of 03:43, 13 February 2025

A synthetic estrogen used in veterinary medicine


Taleranol
INN
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Taleranol is a synthetic estrogen that is primarily used in veterinary medicine. It is a nonsteroidal estrogen that belongs to the class of compounds known as mycoestrogens, which are naturally occurring estrogens produced by fungi.

Chemical structure and properties[edit]

Error creating thumbnail:
Structural formula of Taleranol

Taleranol is a derivative of the mycoestrogen zearalenone, which is produced by several species of Fusarium fungi. The chemical structure of taleranol is characterized by a cyclopenta[a]phenanthrene skeleton, which is typical of many steroidal estrogens, although taleranol itself is nonsteroidal.

Mechanism of action[edit]

Taleranol exerts its effects by binding to estrogen receptors in target tissues. This binding mimics the action of endogenous estrogens, leading to the activation of estrogen-responsive genes. The primary physiological effects of taleranol are similar to those of natural estrogens, including the promotion of growth and development of female secondary sexual characteristics and the regulation of the menstrual cycle.

Uses in veterinary medicine[edit]

In veterinary practice, taleranol is used as a growth promoter in livestock, particularly in cattle. It is administered to improve feed efficiency and promote weight gain. The use of taleranol in animals is regulated to ensure that residues do not remain in meat products intended for human consumption.

Safety and regulation[edit]

The use of taleranol, like other growth-promoting agents, is subject to strict regulatory controls. In some countries, the use of synthetic estrogens in food-producing animals is banned or restricted due to concerns about potential health risks to humans. Monitoring programs are in place to detect residues of taleranol and other similar compounds in meat products.

Related pages[edit]