Veralipride: Difference between revisions

Veralipride
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Latest revision as of 01:56, 17 February 2025

A benzamide antipsychotic drug

Veralipride is a benzamide antipsychotic medication that was primarily used in the treatment of menopausal symptoms. It was marketed under the brand name Agreal and was available in several countries, including Spain and Italy.

Pharmacology[edit]

Veralipride is a dopamine antagonist, which means it works by blocking dopamine receptors in the brain. This action is thought to help alleviate symptoms associated with menopause, such as hot flashes and mood swings.

Uses[edit]

Veralipride was prescribed to manage vasomotor symptoms of menopause, which include hot flashes and night sweats. It was considered an alternative to hormone replacement therapy (HRT) for women who could not take HRT or preferred not to.

Side Effects[edit]

The use of veralipride has been associated with several side effects, including drowsiness, dizziness, and gastrointestinal disturbances. More serious side effects include extrapyramidal symptoms, which are movement disorders that can result from dopamine receptor blockade.

Withdrawal and Controversy[edit]

Veralipride was withdrawn from the market in several countries due to concerns about its safety profile. Reports of psychiatric side effects, such as depression and anxiety, led to increased scrutiny. In 2006, the European Medicines Agency (EMA) recommended the suspension of veralipride's marketing authorization in the European Union.

Related pages[edit]

References[edit]

Veralipride chemical structure
Veralipride molecule ball-and-stick model

@@ Line 1: / Line 1: @@
-'''Veralipride''' is a [[benzamide]] [[antipsychotic]] that is used in Europe, including the United Kingdom, for the treatment of the [[menopausal]] symptoms such as [[hot flashes]] and [[mood swings]]. It is also used in the treatment of [[nausea]] and [[vomiting]], including that caused by [[chemotherapy]], [[radiation therapy]], and in the [[postoperative]] period.
+{{Short description|A benzamide antipsychotic drug}}
+{{Drugbox
+| verifiedrevid = 477318123
+| image = Veralipride.svg
+| image2 = Veralipride_molecule_ball.png
+| width = 200
+}}
-Veralipride works by blocking [[dopamine]] receptors in the brain, which helps to reduce the symptoms of nausea and vomiting. It also has a calming effect, which can help to reduce mood swings and hot flashes.
+'''Veralipride''' is a [[benzamide]] [[antipsychotic]] medication that was primarily used in the treatment of [[menopausal]] symptoms. It was marketed under the brand name ''Agreal'' and was available in several countries, including [[Spain]] and [[Italy]].
 ==Pharmacology==
-Veralipride is a [[dopamine antagonist]], which means it works by blocking the action of dopamine, a neurotransmitter that is involved in many functions in the body, including mood and behavior, as well as nausea and vomiting. By blocking the action of dopamine, veralipride can help to reduce these symptoms.
+Veralipride is a [[dopamine antagonist]], which means it works by blocking [[dopamine]] receptors in the brain. This action is thought to help alleviate symptoms associated with [[menopause]], such as [[hot flashes]] and [[mood swings]].
+==Uses==
+Veralipride was prescribed to manage [[vasomotor symptoms]] of menopause, which include hot flashes and night sweats. It was considered an alternative to [[hormone replacement therapy]] (HRT) for women who could not take HRT or preferred not to.
 ==Side Effects==
-Like all medications, veralipride can cause side effects. These can include [[drowsiness]], [[dizziness]], [[dry mouth]], and [[constipation]]. In rare cases, it can cause serious side effects such as [[tardive dyskinesia]], a condition that causes involuntary movements, and [[neuroleptic malignant syndrome]], a rare but serious condition that can cause fever, muscle stiffness, and altered mental status.
+The use of veralipride has been associated with several side effects, including [[drowsiness]], [[dizziness]], and [[gastrointestinal disturbances]]. More serious side effects include [[extrapyramidal symptoms]], which are movement disorders that can result from dopamine receptor blockade.
-==Interactions==
+==Withdrawal and Controversy==
-Veralipride can interact with other medications, including other antipsychotics, [[antidepressants]], and medications for [[Parkinson's disease]]. It can also interact with alcohol, which can increase the risk of drowsiness and dizziness.
+Veralipride was withdrawn from the market in several countries due to concerns about its safety profile. Reports of [[psychiatric]] side effects, such as [[depression]] and [[anxiety]], led to increased scrutiny. In 2006, the [[European Medicines Agency]] (EMA) recommended the suspension of veralipride's marketing authorization in the [[European Union]].
-==See Also==
+==Related pages==
-* [[Antipsychotic]]
 * [[Menopause]]
-* [[Nausea]]
+* [[Dopamine antagonist]]
-* [[Vomiting]]
+* [[Extrapyramidal symptoms]]
+==References==
+{{Reflist}}
-[[Category:Drugs]]
 [[Category:Antipsychotics]]
-[[Category:Menopause]]
+[[Category:Withdrawn drugs]]
-[[Category:Nausea]]
+[[Category:Benzamides]]
-[[Category:Vomiting]]
+<gallery>
+File:Veralipride.svg|Veralipride chemical structure
-{{stub}}
+File:Veralipride_molecule_ball.png|Veralipride molecule ball-and-stick model
+</gallery>