Substance P: Difference between revisions
CSV import |
CSV import |
||
| Line 1: | Line 1: | ||
'''Substance P''' is a [[neuropeptide]] | == Substance P == | ||
[[File:Substance_P.png|thumb|right|Chemical structure of Substance P]] | |||
'''Substance P''' is a [[neuropeptide]] that functions as a [[neurotransmitter]] and [[neuromodulator]]. It is composed of 11 [[amino acids]] and is a member of the [[tachykinin]] neuropeptide family. Substance P is involved in the transmission of pain information into the central nervous system. | |||
== Structure == | == Structure == | ||
Substance P is | |||
Substance P is a [[polypeptide]] consisting of a chain of 11 amino acids. Its sequence is Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met. The [[molecular weight]] of Substance P is approximately 1347.63 g/mol. The [[chemical structure]] of Substance P allows it to bind to the [[neurokinin-1 receptor]] (NK1 receptor), which is its primary receptor. | |||
== Function == | == Function == | ||
== | Substance P is primarily associated with the [[pain]] pathway. It is released from the terminals of specific sensory nerves and is involved in the [[neurotransmission]] of pain and other sensory signals. Substance P is also involved in the regulation of [[mood disorders]], [[anxiety]], [[stress]], [[nausea]], and [[vomiting]]. | ||
Substance P | |||
=== Pain Transmission === | |||
In the context of pain, Substance P is released from the terminals of [[afferent neurons]] in the [[dorsal horn]] of the [[spinal cord]]. It binds to the NK1 receptor on [[postsynaptic neurons]], leading to the transmission of pain signals to the brain. This process is crucial for the perception of pain. | |||
=== Other Functions === | |||
Substance P also plays a role in the [[inflammatory response]] and is involved in the regulation of the [[immune system]]. It can influence the [[vasodilation]] and [[vascular permeability]] of blood vessels, contributing to the inflammatory process. | |||
== Clinical Significance == | |||
Substance P has been implicated in various [[clinical conditions]], including [[chronic pain]], [[arthritis]], [[fibromyalgia]], and [[depression]]. Antagonists of the NK1 receptor, which block the action of Substance P, are being studied for their potential therapeutic effects in these conditions. | |||
== Related Pages == | |||
* [[Neuropeptide]] | * [[Neuropeptide]] | ||
* [[Neurotransmitter]] | * [[Neurotransmitter]] | ||
* [[ | * [[Pain]] | ||
* [[Neurokinin-1 receptor]] | |||
* [[Neurokinin | * [[Inflammation]] | ||
* [[ | |||
[[Category:Neuropeptides]] | [[Category:Neuropeptides]] | ||
[[Category:Neurotransmitters]] | [[Category:Neurotransmitters]] | ||
Latest revision as of 04:03, 13 February 2025
Substance P[edit]
Substance P is a neuropeptide that functions as a neurotransmitter and neuromodulator. It is composed of 11 amino acids and is a member of the tachykinin neuropeptide family. Substance P is involved in the transmission of pain information into the central nervous system.
Structure[edit]
Substance P is a polypeptide consisting of a chain of 11 amino acids. Its sequence is Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met. The molecular weight of Substance P is approximately 1347.63 g/mol. The chemical structure of Substance P allows it to bind to the neurokinin-1 receptor (NK1 receptor), which is its primary receptor.
Function[edit]
Substance P is primarily associated with the pain pathway. It is released from the terminals of specific sensory nerves and is involved in the neurotransmission of pain and other sensory signals. Substance P is also involved in the regulation of mood disorders, anxiety, stress, nausea, and vomiting.
Pain Transmission[edit]
In the context of pain, Substance P is released from the terminals of afferent neurons in the dorsal horn of the spinal cord. It binds to the NK1 receptor on postsynaptic neurons, leading to the transmission of pain signals to the brain. This process is crucial for the perception of pain.
Other Functions[edit]
Substance P also plays a role in the inflammatory response and is involved in the regulation of the immune system. It can influence the vasodilation and vascular permeability of blood vessels, contributing to the inflammatory process.
Clinical Significance[edit]
Substance P has been implicated in various clinical conditions, including chronic pain, arthritis, fibromyalgia, and depression. Antagonists of the NK1 receptor, which block the action of Substance P, are being studied for their potential therapeutic effects in these conditions.
